UJI AKTIVITAS ANTIBAKTERI SEDIAAN SALEP EKSTRAK BUNGA BELIMBING WULUH (Averrhoa bilimbi L.) TERHADAP BAKTERI PENYEBAB JERAWAT Propionibacterium Acnes  DAN Staphylococcus Epidermidis

TIO RANTI SARI SEMBIRING; Masria Phetheresia Sianipar; Anggun Syafitri; angga nugraha sanjaya

doi:10.36656/kzz03w83

Authors

TIO RANTI SARI SEMBIRING INSTITUT KESEHATAN DELI HUSADA
Masria Phetheresia Sianipar Institut Kesehatan Deli Husada
Anggun Syafitri Institut Kesehatan Deli Husada
angga nugraha sanjaya Institut Kesehatan Deli Husada

DOI:

https://doi.org/10.36656/kzz03w83

Keywords:

Starfruit Flower, Ointment, Antibacterial, Propionibacterium acnes And Staphylococcus Epidermidis

Abstract

Acne is a skin disease often caused by infection with the bacteria Propionibacterium acnes and Staphylococcus epidermidis. Long-term use of antibiotics can lead to bacterial resistance, necessitating alternative treatments derived from natural ingredients. Starfruit flowers (Averrhoa bilimbi L.) are known to contain secondary metabolites such as flavonoids, saponins, tannins, terpenoids, and polyphenols, which have antibacterial potential. This study aimed to formulate an ethanol extract of starfruit flowers into an ointment, evaluate the physical characteristics of the preparation, and determine its antibacterial activity against Propionibacterium acnes and Staphylococcus epidermidis. This was an experimental study. Starfruit flower samples were processed into crude drugs, then characterized and phytochemically screened. Extraction was carried out using a maceration method with 96% ethanol as a solvent. The resulting extract was formulated into ointment preparations at concentrations of 10%, 15%, and 20%. The ointment preparations were then evaluated for organoleptic properties, homogeneity, pH, spreadability, and irritation. It is recommended that future research conduct antibacterial testing on different formulations of the ethanolic extract of (Averrhoa bilimbi L). flowers.

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References

Agustin, D., Zaenab, S., Agus, M., Budiyanto, K., & Hudha, A. M. (2021). Pengaruh Konsentrasi Ekstrak Bunga Belimbing Wuluh Terhadap Zona Hambat Pertumbuhan Streptococcus pyogenes. Jurnal Bioterdidik, 7(6), 14–25.

Angelia, T., Yuliastri, W. O., & Nurlila, R. U. (2022). Formulasi dan Uji AKtivitas Antijerawat Sediaan Salep Dari Ekstrak Etanol Buah Alpukat (Persea americana Mill.) Terhadap Bakteri Propionibacterium acnes. Jurnal Pharmacia Mandala Waluya, 1(4), 145–157. https://doi.org/10.54883/28296850.v1i4.131

Anggraeni. (2020). UJI KARAKTERISTIK SIMPLISIA BUAH ANDALIMAN(Zanthoxylum acanthopodiumDC.). 3(2), 32–38. https://jurnal.uimedan.ac.id/index.php/JURNALFARMASI 32Journalho mepage:https://jurnal.uimedan.ac.id/index.php/JURNALFARMASI

Asworo, R. Y., & Widwiastuti, H. (2023). Pengaruh Ukuran Serbuk Simplisia dan Waktu Maserasi terhadap Aktivitas Antioksidan Ekstrak Kulit Sirsak. 3(2), 256–263. https://doi.org/10.37311/ijpe.v3i2.19906

Badia, E., Yodha, A., Musdalipah, Nohong, Sahidin, & Asril. (2022). Meistera Chinensis Stem Extract Ointment Dosage Formulation. Jurnal Warta Farmasi, 11(2), 19–28. https://doi.org/10.46356/wfarmasi.v8i1

Chezar R, M., Hasanuddin, S., & Dewi, C. (2025). Uji Aktivitas Antibakteri Ekstrak Etanol Daun Kelengkeng (Dimocarpuslongan L.) Terhadap Bakteri Propionibacterium acne dan Staphylococcus epidermidis. Jurnal Pharmacia Mandala Waluya, 4(1), 9–16. https://doi.org/10.54883/jpmw.v4i1.147

Diningsih, A., & Antoni, A. (2020). ISOLASI SENYAWA FLAVONOID BUNGA BELIMBING WULUH ( Averrhoa Bilimbi L . ) SERTA UJI AKTIVITAS ANTIBAKTERI TERHADAP BAKTERI Staphylococcus Aureus. 8(4), 518–522.

Enjelina, S. M., Pambudi, R. S., Ramadhani, M., & Subiyanto, A. F. (2024). FORMULASI DAN UJI FISIK SALEP KOMBINASI EKSTRAK PUTRI MALU ( Mimosa Pudica ) DAN DAUN JARAK PAGAR ( Jatropha Curcas ) PENDAHULUAN Indonesia merupakan negara dengan yang memiliki kekayaan alam dengan manfaat yang beraneka ragam dan dapat dimanfaatkan sebag. 4(3), 287–293.

Estikomah, S. A., Sri, A., Amal, S., & Safaatsih, S. F. (2021). Gel Semprot. 5(1), 36–53.

farmakope VI. (2020). farmakope indosnesia. https://doi.org/10.1136/bmj.2.5096.601

Farras, A., Hasbi, N., & Parwata, W. S. S. (2024). Potential Test of Lactic Acid Bacteria from Infant Feces on The Growth of Staphylococcus epidermidis. Jurnal Biologi Tropis, 24(4), 807–817. https://doi.org/10.29303/jbt.v24i4.7554

FHI, 2017. (2017). HERBAL INDONESIA HERBAL.

Guli, M. M., Priyandini, N., Lambui, O., Ardiputra, M. A., & Toemon, I. (2024). UJI EFEKTIVITAS ANTIBAKTERI EKSTRAK DAUN KAYU HITAM ( Diospyros celebica Bakh .) TERHADAP BAKTERI Staphylococcus aureus DAN Salmonella typhi TESTING THE ANTIBACTERIAL EFFECTIVENESS OF KAYU HITAM LEAF EXTRACT ( Diospyros celebica Bakh .) AGAINST THE BACTER. 12(1), 39–46. https://doi.org/10.37304/jkupr.v12i1.13189

Hikmah, S. N., Mukti, Y. A., & Santoso, B. I. (2026). Formulasi Sediaan Salep Ekstrak Etanol Daun Jambu Biji ( Guajava Linn .) Untuk Pengobatan Luka Bakar Dengan Konsentrasi Basis Hidrokarbon. 4(4), 169–173.

Husein et, al. (2025). EFEKTIVITAS SINTESIS CAO NANOPARTIKEL DENGAN BAWANG PUTIH (ALLIUM SATIVUM L.) SEBAGAI ANTIBAKTERI. 5(3), 418–433.

Imansyah, M. Z., Hamdayani, S., Farmasi, A., Makassar, Y., Farmasi, A., & Makassar, Y. (2022). Jurnal Kesehatan Yamasi Makassar. 6(1), 40–47.

Jannah, M., Nasution, H. M., Nasution, M. P., Rahayu, Y. P., Farmasi, P. S., Farmasi, F., Al-washliyah, U. M. N., & Utara, S. (2023). No Title. 6(4), 1686–1692.

Khairunnisa, A., Yuniarti, R., Indrayani, G., & Rani, Z. (2025). ORIGINAL ARTICLE Characterization , Screening , and Antibacterial Activity Assay of Ethanol Extract of Torch Ginger ( Etlingera elatior ( Jack ) R . M . Sm ) Flowers Against Staphylococcus aureus Karakterisasi , Skrining dan Uji Aktivitas Antibakteri Ekstrak Etanol Bunga Kecombrang ( Etlingera elatior ( Jack ) R . M . Sm ) terhadap Staphylococcus aureus Abstrak Pendahuluan. 8(2), 1033–1046.

Kolopita, P. S., Hariyadi, H., Sambou, C. N., & Tulandi, S. S. (2022). Uji Aktivitas Antibakteri Kulit Batang Alpukat (Persea americana Mill) Terhadap Bakteri Staphylococcus aureus Dan Escherichia coli. Majalah INFO Sains, 3(1), 19–26. https://doi.org/10.55724/jis.v3i1.46

Laili, N., Hidayati, D., Asih, S., & Zustika, D. S. (2023). Karakteristik Mutu Simplisia Dan Uji Aktivitas Antioksidan Beberapa Ekstrak Daun Mengkudu (Morinda citrifolia L.) Menggunakan Metode DPPH (2,2- difenil-1-pikrilhidrazil). Prosiding Seminar Nasional Diseminasi Penelitian, 3(September), 2964–6154.

Mandiri, C. M. (2025). Biologi Farmasi (Vol. 32, Issue 3).

Maqfirah, Z., Muhammad, amin nasution, M. Pandapotan, N., & Haris, M. N. (2023). Penetapan_kadar_flavonoid_total_ekstrak_etanol_fra (1). Journal of Pharmaceutical and Sciences, 6(4), 1534–1543. https://www.journal-jps.com

Niswa, K., Dalimunthe, G. I., & Nasution, H. M. (2024). FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN EKSTRAK SALEP UBI JALAR UNGU ( Ipomoea batatas ( L .)) Lamk TERHADAP BAKTERI Staphylococcus aureus PADA PENYEMBUHAN PENYAKIT LUKA BERNANAH FORMULATION AND ANTIBACTERIAL ACTIVITY TEST OF PURPLE SWEET POTATO E. 3(2), 205–222.

Nuraskin, C. A., Mardelita, S., Kesehatan, P., Poltekkes, G., Aceh, K., Terapi, P., Poltekkes, G., Aceh, K., Terapi, P., Poltekkes, G., & Aceh, K. (2022). Identifikasi Metabolit Sekunder Ekstrak Buah Belimbing. Jurnal Mutiara Ners, 5(2), 120–126.

Pariury, J., Husodo, S. D., Kumala, A. R., & Rahayu, I. N. (2021). Hang tuah medical journal. Hang Tuah Medical Journal, 19(1), 100–113.