FORMULASI DAN UJI EFEKTIVITAS SEDIAAN EKSTRAK ETANOL KULIT PEPAYA (Carica papaya L) SEBAGAI BRIGHTENING GEL SERUM
Abstract
Facial skin problems that often occur in women and adolescents are dull skin and dark looking skin. Papaya peel (carica papaya L) contains flavonoid compounds which function as antioxidants to brighten the skin. This study aims to formulate papaya peel extract into a serum gel dosage form and observe its effectiveness on the skin of volunteers for 4 weeks of treatment. The research was started by making papaya peel extract which was obtained by maceration method. Then the extract was formulated into serum gel preparations with varying concentrations of gelling agent Carbomer 940 4%, 5%, 6%. The preparations were eval_uated for their physical characteristics, namely organoleptic test, pH test, spreadability test, viscosity test, homogeneity test, irritation test, and test volunteer. The results showed that papaya peel extract could be formulated into a serum gel preparation that was homogeneous, light brown in color, had a spreadability of <5 cm, with a pH <6, and had a viscosity of >2000 cps. Serum gel formula containing Carbomer 940 with a concentration of 6% which has the best effectiveness.
Downloads
References
Asra, R. R. (2020). Physicochemical Study Of Betasianin And Antioksidant ActivitiesnOf Red Beet Tubers ( beta vulgaris L). Journal of Pharmaceutical and Sciences, 3(1), 14-21.
Astuti, (2018). Skrining Fitokimia Pepaya. Jurusan Farmasi, Universitas Udayana
Bolton, S. B. (2010). Pharmaceutical Statistic and Clinical Application. New York: Marcel Dekker Inc.
Cristalina, (2018). Aktivitas Antioksidan dan Anti Bakteri Kulit Pepaya.
Depkes. (2010). Farmakope Herbal Indonesia Edisi Ketiga. Dapertemen Kesehatan Republik Indonsia Halaman 10-15.
Draelos, Z. (2020). "A dauble-blind, randomized clinical trial eval_uating the dermatologic benefits of coffe berry extract" journal of the American Academy of Dermatalog, 58 (2), suplement 2,p.AB64.
Febriyenti. (2018). Aktivitas Antioksidan dan Tabir Surya Ektrak Daun Afrika. Samarinda: Skripsi,Fakultas Farmasi Universitas Mulawarman.
Hasrawati A., H. (2020). Pengembangan Ekstrak Etanol Limbah Biji Pepaya ( carica papaya L) Sebagai Serum Antijerawat,. Jurnal Fitofarmaka Indonesia 7(1),pp 1-8.
Ida N. and Noer S.F.( 2012). Uji Stabilitas Fisik Gel Ekstrak LIdah Buaya (Aloe vera L), Majalah Farmasi dan Farmakologi.
Ismail. (2017). Formulasi Kosmetik Produk Perawatan Kulit dan Rambut . Makasar: Jurnal Ilmiah Universitas Alauddin.
Kartika, D. D. (2020). Trend perawatan kecantikan perempuan.
Komoro, A. (2019). Teknologi Ekstraksi Senyawa Bahan Aktif dari Tanaman obat. . Yogyakarta: Plantaxia.
Kusantati, H. (2017). Tata Kecantikan Kulit Jilid I. Jakarta: Direktorat Pembinaan Sekolah Menengah Kejuruan Halaman 59-105.
Lachman L., L. (Jakarta). Teori dan Praktek Farmasi Industri Edisi Ketiga,. 2018: Universitas Indonesia.
Margarreta, S. (2018). Ekstraksi Senyawa Phenolik Pandanus Amaryllifolius Roxb.Sebagai Antioksidan dan Alami Teknik Vol 10,NO.1.
Marjoni. (2016). Dasar-Dasar Fitokimia Untuk Diploma III Farmasi. Jakarta : Trans Info Media.
Marliani L, V. (2018). Aktivitas Antioksidan dan Tabir Surya Pada Ekstrak Kulit Buah Pepaya ( carica papaya L) Prosiding SNaPP k.
McDaniel, D. (2017). Atmospheric skin aging Contributors and inhibitors. J Cosmet Dermatol 17(2):124-137.
Mitsui. (1997). New Cosmetic Science.Elseveir Science, B.V. Amsterdam: Netherlands.
Pratiwi, (2018) Aktivitas Antioksidan Masker Wajah Kulit Pepaya (carica papaya L).
