Jurnal Penelitian Farmasi & Herbal

FORMULASI DAN eval_UASI SEDIAAN SHAMPOO EKSTRAK ETANOL DAUN CENGKEH (Syzygium aromaticum) SEBAGAI PENUMBUH RAMBUT PADA TIKUS PUTIH

Pintata Sembiring — Wed, 06 Nov 2024 04:26:09 SE Asia Standard Time

Daun Cengkeh (Syzygium aromaticum) memiliki khasiat untuk mengatasi permasalahan pertumbuhan rambut. Yang dimana senyawa yang terkandung didalam daun cengkeh adalah eugenol yang berkhasiat sebagai penumbuh rambut. Tujuan dari penelitian iniadalah mengetahui sebuah efektivitas dari suatu sediaan shampoo dengan menggunakan ekstrak etanol daun cengkeh sebagai pembantu dalam mengatasi rambut rontok, dengan menggunakan formula 10%, 20%, dan 30%. Ekstrak dibuat dengan metode perendaman menggunakan pelarut etanol 96%. Hewan uji pada penelitian rambut/bulu dicukur yang dimana akan diuji menggunakan 5 ekor tikus yang masing masing bulunya telah dicukur dengan ukuran 3x3 cm. Kelompok pertama (kontrol positif), kelompok kedua (kontrol negatif), kelompok ketiga (Shampoo Ekstrak Etanol Daun Cengkeh 10%), kelompok 4 (Shampoo Ekstrak Etanol Daun Cengkeh 20%) dan kelompok kelima (Shampoo Ekstrak Etanol Daun Cengkeh 30%). Parameter dalam penelitian ini adalah diameter sebagai pertumbuhan rambut. Hasil penelitian ini menunjukkan bahwa shampoo dari ekstrak etanol daun cengkeh dengan konsentrasi 30% adalah formulasi sediaan yang paling efektif dalam pertumbuhan rambut pada tikus jantan. Sediaan shampoo ekstrak etanol daun cengkeh kurang efektif dibandingkan dengan shampoo Clear pada pertumbuhan rambut.

Kajian Literatur: Aplikasi Sejumlah Metode Ekstraksi Konvensional untuk Mengekstraksi Senyawa Fenolik dari Bahan Alam

Mochammad Rasyad Arrofiqi, Aditya Sindu Sakti, Fransisca Dita Mayangsari — Wed, 06 Nov 2024 04:27:11 SE Asia Standard Time

This literature review explores various conventional extraction methods utilized to extract phenolic compounds from natural materials. Phenolic compounds, known for their significant antioxidant, anti-inflammatory, and anticancer properties, are crucial bioactive molecules found in plants. The study examines methods such as maceration, percolation, reflux, Soxhlet, digestion, infusion, and decoction, highlighting their efficiencies, advantages, and limitations. The findings suggest that while conventional methods are cost-effective and accessible, they often require longer extraction times and may lead to thermal degradation of sensitive compounds

- KAJIAN PENGGUNAAN ANTIBIOTIK PADA Neonatus Intensif Care Unit DI RUMAH SAKIT UMUM SEMBIRING DELI TUA

Sofia - Rahmi — Wed, 06 Nov 2024 04:28:01 SE Asia Standard Time

Infancy is the period after birth before 59 months of age. Death in infants can be caused by several things, and one of the biggest causes of death in infants is due to infection. increased risk of therapeutic failure, one of the impacts that need to be aware of is the potential for resistance when the antibiotics given cannot reach the minimum level to inhibit growth or kill bacteria. The occurrence of problems in NICU patients due to antibiotic use caused by antibiotic use. This research method is by collecting data obtained from medical records and families of patients treated at Sembiring Delitua General Hospital by observing the use of antibiotics for 28 days. The results obtained were several antibiotics, namely Cefotaxime, Gentamicin, Cefadroxil, Ampicillin, and Meropenem. The conclusion of this study is that the type of antibiotic used is cefotaxime, the results of the analysis of antibiotic suitability in patients who receive a diagnosis of infection are in accordance with the needs of the patient and have fulfilled the 4T1W criteria (right drug, right patient, right indication and alert side effects).

Hiperlipidemia Uji Efektivitas Antihiperlipidemia Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Pada Tikus Putih Jantan Yang Di Induksi Fruktosa

Evi Depiana Gultom — Wed, 06 Nov 2024 04:28:01 SE Asia Standard Time

Hyperlipidemia is a condition of high lipid concentration which is characterized by increased concentrations of triglycerides, LDL (Low Density Lipoprotein), blood cholesterol that exceeds normal limits which is one of the risk factors for cardiovascular disease. Kersen leaf has contains secondary metabolites of flavonoids and saponins which are thought to reduce cholesterol levels in the blood. The aim of this study was to determine the antihyperlipidemic effectiveness of ethanol extract of kersen leaf (EEDK/EEKL) in fructose-induced male white rats. Testing the effectiveness of antihyperlipidemia was carried out using an experimental method using fructose-induced male rats as test animals. The test animals were divided into 5 groups, namely negative control (CMC Na 1%), positive control of simvastatin (0.9 mg/kgBB), EEDK dose of 350 mg/kgBB, EEDK dose of 400 mg/kgBB, EEDK dose of 500mg/kgBB. Cholesterol levels were measured using the point of care testing (POCT) method. The data obtained were analyzed statistically using the one way ANOVA test. The results of the analysis showed that there were significant differences between the negative control, positive control, EEDK 350 mg/kg, EEDK 400 mg/kg and EEDK 500 mg/kg (P<0.05). The decrease in cholesterol levels increased in line with the increase in the dose of cherry leaf ethanol extract. The most effective EEDK as antihyperlipidemia is the EEDK at a dose of 500 mg/kg BW. There was no significant difference between the positive control and the 500 mg/kg BW EEDK dose (P>0.05). Based on the results of the statistical analysis that has been carried out, it can be concluded that the ethanol extract of cherry leaves has an antihyperlipidemic effect on rats.

FORMULASI DAN UJI EFEKTIVITAS SEDIAAN EKSTRAK ETANOL KULIT PEPAYA (Carica papaya L) SEBAGAI BRIGHTENING GEL SERUM

Anggun Syafitri, Masria Phetheresia Sianipar; Ardhana Fantika — Wed, 06 Nov 2024 04:28:01 SE Asia Standard Time

Facial skin problems that often occur in women and adolescents are dull skin and dark looking skin. Papaya peel (carica papaya L) contains flavonoid compounds which function as antioxidants to brighten the skin. This study aims to formulate papaya peel extract into a serum gel dosage form and observe its effectiveness on the skin of volunteers for 4 weeks of treatment. The research was started by making papaya peel extract which was obtained by maceration method. Then the extract was formulated into serum gel preparations with varying concentrations of gelling agent Carbomer 940 4%, 5%, 6%. The preparations were eval_uated for their physical characteristics, namely organoleptic test, pH test, spreadability test, viscosity test, homogeneity test, irritation test, and test volunteer. The results showed that papaya peel extract could be formulated into a serum gel preparation that was homogeneous, light brown in color, had a spreadability of <5 cm, with a pH <6, and had a viscosity of >2000 cps. Serum gel formula containing Carbomer 940 with a concentration of 6% which has the best effectiveness.

Jhan Saberlan Purba

Jhan Saberlan Purba — Wed, 06 Nov 2024 04:31:08 SE Asia Standard Time

Rhodamin B merupakan pewarna sintetik yang digunakan sebagai zat warna tekstil, rhodamin B tidak diperbolehkan digunakan pada produk makanan karena sangat berbahaya bagi kesehatan manusia. Rhodamin B mempunyai sifat kimia dan kandungan logam berat seperti senyawa alkilasi (CH3-CH3) dan juga mengandung senyawa (Cl) yang bersifat radikal yang dapat berikatan dengan DNA, protein dan lemak dalam tubuh, sehingga senyawa yang terikat tidak ada. lagi berfungsi dengan baik dan kinerja tubuh tidak lagi optimal, apabila rhodamin B terakumulasi dalam konsentrasi tinggi dalam tubuh dapat menyebabkan penyakit liver. Menurut Direktur Jenderal Badan POM No.00366/C/II/1990 menyatakan bahwa pewarna rhodamin B termasuk dalam 30 bahan pewarna yang tidak boleh ditambahkan pada makanan. Namun nyatanya rhodamin B masih terdapat pada berbagai produk pangan untuk memberikan warna yang lebih kuat, salah satunya pada saus. Tujuan: Penelitian ini bertujuan untuk menganalisis keberadaan dan kadar rhodamin B yang terdapat pada kuah bakso bakar yang beredar di Deli Tua. Metode : menggunakan metode uji warna kualitatif dan spektrofotometri tampak secara kuantitatif. Hasil: hasil analisis kualitatif dengan metode uji warna 3 dari 9 sampel yang digunakan teridentifikasi positif mengandung rhodamin B dengan kode sampel A, sampel B, dan sampel H ditandai dengan terbentuknya warna merah jambu. Analisis kuantitatif spektrofotometri tampak diperoleh panjang gelombang maksimum 545 nm dengan kadar rhodamin B pada sampel saus kode A 13,79744215 (± 2,76035 µg/mL), sampel saus B sebesar 11,31734153 (± 2,2615 µg/mL) , dan sampel saus H sebesar 12,12968009 (± 2,4214 µg/mL), konsentrasi tertinggi terdapat pada sampel saus A. Kesimpulan: dari penelitian ini terdapat beberapa saus bakso bakar yang digunakan oleh pedagang bakso panggang di Deli Tua masih mengandung pewarna rhodamin B

A The Formulation And Stability Formulation And Stability Testing Of Lotion From Ethanol Extract Pagoda Flower (Clerodendrum Paniculatum L.) And Rhizomes Key Find (Boesenbergia Rotunda (L.) Mansf.) As Antioxidant

Bunga Barus Barus — Wed, 06 Nov 2024 04:31:42 SE Asia Standard Time

Unhealthy lifestyles and air pollution can cause the number of free radicals in the body to increas. The formation of free radicals is a widely accepted important mechanism that causes skin aging. For this reason, the body needs antioxidants that can neutralize very dangerous free radicals. A plant whose efficacy as an antioxidant has been proven is the pagoda flower plant. Another plant used to ward off free radicals is the rhizome of Temu Kunci (Boesenbergia rotunda (L.) Mansf.) which is from the Zingiberaceae family which has compounds that have the potential to act as antioxidants. This research aims to formulate a lotion preparation of pagoda flower extract and ginger root rhizome extract as well as carrying out a stability test of the preparation and determining the IC 50 value using the DPPH method. The research used the maceration method with 96% ethanol. Then the extract is formulated into a lotion with varying concentrations of pagoda flower extract: ginger rhizome extract, namely: F1(1:1); F2(2:1); F3(1:2). The preparations of pagoda flower extract lotion and ginger root rhizome extract were eval_uated for organoleptic tests, pH tests, homogeneity tests, viscosity tests and hedonic tests and antioxidant tests were carried out with a wavelength of 516nm. The results of the research on pagoda flower extract lotion and ginger root rhizome extract have met the requirements for organoleptic tests, pH test, homogeneity test, and viscosity test. The IC50 value of the lotion preparation of ethanol extract of pagoda flowers and ethanol extract of ginger rhizome showed a strong category (50-100) with an IC50 value of F1 86.13 µg/ml, F2 73.91 µg/ml and F3 75.83 µg/ml.

PENETAPAN KADAR AKRILAMIDA DALAM MAKANAN KAKI LIMA KENTANG GORENG DI PASAR TRADISIONAL DELI TUA DENGAN METODE HPLC (High Performance LiquidChromatography))

sulasmi sulasmi — Wed, 06 Nov 2024 04:31:42 SE Asia Standard Time

ABSTRACT

Background: This study examines acrylamide levels in french fries sold in the traditional market of Deli Tua using the High Performance Liquid Chromatography (HPLC) method. Purpose: is to identify the concentration of acrylamide contained in the samples, as well as provide information regarding the potential health risks associated with the consumption of foods containing the compound. This research Method : is descriptive, carried out in the Quantitative Analysis Chemistry Laboratory, Faculty of Pharmacy, Deli Husada Institute of Health. French fries samples were taken from traders at the Deli Tua traditional market. Acrylamide levels were analyzed using the High Performance Liquid Chromatography (HPLC) method, with procedures including standard solution preparation and measurement using a UV-VIS detector. Results: showed that all the French fries samples analyzed contained acrylamide with varying concentrations. The average acrylamide content in the sample from trader A was 0.7%, while from trader B was 0.5%. These findings show that the acrylamide levels in the fries circulating in the Deli Tua traditional market are not in accordance with the standards set by the Regulation of the Minister of Health. Conclusion: of this study is that the fries sold in the Deli Tua traditional market contain acrylamide with levels that exceed the safe limit. It is recommended to the public to be more careful in choosing fast food, especially french fries. Further research is suggested to use other analysis methods, such as FTIR, with different solvents to obtain more comprehensive results.

FORMULASI DAN UJI EFEKTIVITAS SEDIAAN GEL KOMBINASI DARI EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus) DAN DAUN PEPAYA (Carica papaya L) TERHADAP PENYEMBUHAN LUKA BAKAR TIKUS PUTIH JANTAN (Rattus norvegicus)

TIO RANTI SARI SEMBIRING — Wed, 06 Nov 2024 04:31:43 SE Asia Standard Time

ABSTRACK

Background: According to research conducted at Cipto Mangunkusumo Hospital (RSCM) in 2011-2012, it was reported that the average age was 28 years from a range of 2.5 months to 76 years, while the mortality rate was 36.6% in patients with extensive burns. more than 60.0% of them all experienced death. Research was carried out at the Pharmaceutical Biology Laboratory and the Pharmaceutical Qualitative Laboratory at the Deli Husada Deli Tua Health Institute, as well as at the Pharmaceutical Preparation Technology Laboratory for the manufacture of extracts and gel preparations. The research took place from March to May 2024. This research is a laboratory experimental research. The research population is jackfruit leaves and papaya leaves. The samples used were jackfruit leaf and papaya leaf extracts with concentrations of 3%, 6%, 9%, as well as bioplacenton gel. Research procedures include making simplicia, making extracts using the maceration method, characterization of simplicia, as well as formulation and quality eval_uation of gel preparations. Effectiveness testing was carried out by observing the healing time of burn wounds in mice treated with ethanol extract gel from jackfruit leaves and papaya leaves. The results of this study showed that the effectiveness of healing burn wounds from the combination of ethanol extracts from jackfruit leaves and papaya leaves every day in each formulation. In the positive control (bioplasma) at a concentration of 6% there was no significant difference of p0.05 on days 3, 6, 12 and 15. On day 9 there was a significant difference of p0.05 in each formulation. However, it can be concluded that the 6% concentration is the most effective in healing burns. The bioplacenton gel preparation has better effectiveness in healing wounds compared to the gel preparation combining the ethanol extract of jackfruit leaves and papaya leaves.

Keywords: Artocarpus heterophyllu,Carica papaya L, effectiveness test

UJI AKTIVITAS PRODUK KECANTIKAN FACIAL WASH TERHADAP BAKTERI PENYEBAB JERAWAT (Propionibacterium acnes)

Wed, 06 Nov 2024 04:32:04 SE Asia Standard Time

Background: Acne occurs on the surface of the skin of the face, neck, chest, and back when the oil glands in the skin are overactive so that the pores of the skin will be clogged with excessive fat deposits. If the deposits are mixed with sweat, dust, and other dirt, it can cause fat deposits with black spots on them called blackheads. If the blackheads have a bacterial infection, then there is an inflammation known as acne, one of the bacteria is Propionibacterium acnes. Objective: This study aims to test the antibacterial activity of face wash containing gotu kola leaf, moringa leaf, and green tea leaf extracts. Results: Inhibition zone test results obtained facial wash containing gotu kola leaf extract (Facial wash B), moisture test results obtained that facial wash containing green tea leaf extract (Facial wash C) is more effective in moisturizing the skin, brightness test results obtained that facial wash containing moringa leaf extract (Facial wash A) is more effective in brightening the skin.

UJI EFEKTIVITAS HIPERKOLESTEROLEMIA EKSTRAK ETANOL DAUN KECIPIR (Psophocarpus tetragonolobus L) PADA TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI KUNING TELUR BEBEK

masria phetheresia sianipar, Anggun Syafitri, Pintata Sembiring — Wed, 06 Nov 2024 04:32:13 SE Asia Standard Time

This study explored the effectiveness of winged leaf ethanol extract (Psophocarpus tetragonolobus L) in lowering cholesterol levels in male white rats (Rattus norvegicus) induced with duck egg yolk. An experimental method was used to eval__uate the impact of the extract on cholesterol levels, with the aim of providing an alternative treatment of hyperglycoleemia based on natural ingredients. The results show the significant potential of the extract. This research method uses an experimental approach with laboratory design. Male white rats (Rattus norvegicus) were divided into treatment and control groups. Winged leaf ethanol extract was administered to the treatment group, while the control group did not receive the treatment. Cholesterol level measurements were carried out after induction with duck egg yolk, to eval__uate the effectiveness of the extract in lowering cholesterol levels. The results showed that the administration of winged leaf ethanol extract significantly reduced total cholesterol, LDL, and triglyceride levels in induced male white rats. The group that received the highest dose of the extract showed the most favorable reduction in cholesterol levels, close to the effects of simvastatin. These findings indicate the potential of winged leaves as an alternative in the management of hypercholesterolemia. The conclusion of this study showed that winged leaf ethanol extract (Psophocarpus tetragonolobus L) was effective in lowering cholesterol levels in induced male white rats. A dose of 300 mg/kgBB has been shown to be the most effective. Recommendations for further research are to explore different dosage forms and extract concentrations, as well as conduct toxicity studies to ensure their safe use as a hypercholesterolemia therapy.

Diabetes UJI EFEKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Vernonia amygdalina) dan BUNGA ASOKA (Ixora paludosa) TERHADAP PENURUNAN KADAR GLUKOSA DARAH TIKUS YANG DIINDUKSI ALOKSAN

Evi Depiana Gultom — Wed, 06 Nov 2024 04:32:47 SE Asia Standard Time

Diabeiteis meillitus is a diseiasei in which blood glucosei leiveils increiasei duei to damagei to pancreiatic ceill, meitabolic disordeirs and insulin reisistancei which can bei treiateid with traditional meidicineis deiriveid from plants. Onei eixamplei of a plant that can loweir blood glucosei leiveils is Afrika Leiaf and Asoka Floweir which contains flavonoids to loweir blood glucosei by increiasing ceill seinsitivity to insulin and stimulating insulin reileiasei in pancreiatic β ceills. To deiteirminei thei eiffeict of Afrika leaves and Asoka Floweir eixtract in loweiring blood glucosei leiveils compareid to glibeinclamidei. Expeirimeintal study using 25 rats induceid by alloxan and divideid into 5 groups. Group 1 (neigativei control) CMC Na 1%, group 2 (positivei control) glibeinclamidei dosei 0.45 mg/kg, group 3 Afrika leiaf and Asoka floweir eixtract dosei 100+50 mg/kgBB, group 4 Afrika leiaf and Asoka floweir eixtract dosei 200+100 mg/kgBB and group 5Afrika leiaf and Asoka floweir eixtract dosei 300+150 mg/kgBB. Extraction using maceiration meithod with 96% eithanol solveint. From thei reisults of thei study eiach treiatmeint group eixpeirieinceid a deicreiasei in blood glucosei leiveils. Of thei 5 treiatmeint groups, thei deicreiasei in blood glucosei leiveils that was comparablei to that of glibeinclamidei was thei Afrika Leiaf and Asoka Floweir eithanol eixtract group at a dosei of 300+150 mg/Kg BB.