Jurnal Penelitian Farmasi & Herbal

FORMULASI SEDIAAN HAIR TONIC EKSTRAK ETANOL DAUN TEH HIJAU (Camellia sinensis L.) SEBAGAI PENUMBUH RAMBUT TERHADAP KELINCI JANTAN (Oryctolagus cuniculus)

Pintata Sembiring — 2024-05-05

Background: hair loss is less or more hair than normal, with or without visible thinning. Green tea leaf minoxidil, whixh contains flavonoid compounds that may prevent hair loss, can be used to treat hair loss. Objective: this study aims to confirm whether green tea leaf ethanol extract can be used as a hair restorer that meets the requidments of physical stability, and to investigate the efficacy of green tea leaf extract hair restorer compared with minoxidil on hair growth purpose. Methods: This study used an experimental method that was macerated using 96% ethanol as a solvent. The formula was made into 3 concentrations, namely 2.5%; 5%; 7.5% compared with the drug minoxidil as a positive control. The three formulas were first evaluated to meet the requirements for hair tonic stability, then the hair effectiveness test was carried out with the test animal being a male rabbit. Results: the group that had the highest effectiveness on hair growth in rabbits was minoxidil which had an average value on the 7th, 14th and 21st days of 4.9 ; 6.3 ; 7.9 followed by the third formula which has a concentration of 7.5% as much as 4.5; 5.2 ; 6.5. While the negative control which was only applied with a hair tonic base only had hair growth 1,4; 1,9 ; 2,3. Conclusion: The preparation of hair tonic formula 1 to formula 3 met the requirements for physical stability, namely, pH test, viscosity test and organoleptic test. The preparation of hair tonic ethanol extract of green tea leaves (Camellia sinensis L.) showed that the 7.5% concentration was more effective in accelerating hair growth compared to formulas 1 and 2, and also showed that the 7.5% concentration had almost the same effectiveness as minoxidil (positive control).

ANALISIS ANTIOKSIDAN EKSTRAK DAUN NANGKA (Artocarpus heteropyllus L ) DENGAN MENGGUNAKAN METODE FRAP

sulasmi sulasmi — 2024-05-05

Background: Antioxidants are compounds that are able to counteract or reduce the negative effects of oxidants in the body. The activity of antioxidants is the ability of jackfruit leaves to ward off free radicals. Jackfruit leaf (Artocarpus heteropyllus L.) belongs to the Moraceae family which contains secondary metabolites. The results showed that jackfruit leaves are used as natural antioxidants because they contain secondary metabolites, namely flavonoids, saponins and tannins. Purpose : of this study was to determine the level of antioxidant activity of jackfruit leaf extract using ferric chloride reagent using Ultraviolet-Visible (Uv-Vis) spectrophotometry. Methods : This study used an experimental method, simplicia was extracted by maceration using 96% ethanol and the filtrate obtained was evaporated with the help of a rotary evaporator. Jackfruit leaf extract was analyzed for antioxidant activity with ferric chloride reagent using UV-Vis spectrophotometry in the range of 400 nm-800 nm. Results : of phytochemical screening of jackfruit simplicia powder obtained flavonoid compounds, saponins and tannins. The of the determination of antioxidant levels of ascorbic acid at a wavelength of 236 nm with levels of 87.4712 mgQE/g and levels of jackfruit leaves at a wavelength of 400 nm with levels of 1.2736 mg AAE/g. Conclusion : The results showed that the IC50 value of jackfruit leaves had a value of 74.6 ppm.

ANALISIS KETERKAITAN NETWORK PHAMACOLOGY SENYAWA METABOLIT SEKUNDER Abrus precatorius L. SECARA IN SILICO

Azka Khoirunnisa — 2024-05-05

Cancer remains a global health challenge, prompting extensive research efforts worldwide. Lung cancer, the second most diagnosed cancer, presents a particularly grim survival rate. In Indonesia, cancer incidence ranks significantly, with millions affected and hundreds of thousands succumbing to the disease annually. Traditional medicine persists as a preferred option among many, perceived as safer and more affordable. Abrus precatorius L., an ancient medicinal plant, holds promise in this regard, with a rich history of use and a diverse range of pharmacological activities, including anti-cancer properties. Employing in silico modeling and network pharmacology, this study explores the interaction between Abrus precatorius L. compounds and various proteins associated with cancer. Through bioinformatics tools and databases, 27 bioactive compounds are identified and their physicochemical properties assessed, ensuring adherence to pharmacological guidelines. The study predicts potential protein targets for Abrus precatorius L. compounds, revealing interactions with 453 proteins, including those implicated in cancer pathways. Further analysis using StringDB and DISEASES database establishes protein-protein interaction networks, highlighting key proteins like EGFR and TERT, pivotal in multiple cancer types. The study validates the compounds' adherence to Lipinski's Rule of Five, indicating their potential for pharmacological activity and oral absorption. False Discovery Rate (FDR) analysis confirms significant associations between Abrus precatorius L. compounds and various cancers, further underscoring their therapeutic potential. In conclusion, Abrus precatorius L. compounds, particularly targeting EGFR and TERT proteins, emerge as promising candidates for cancer treatment. Their diverse pharmacological activities and interactions with key cancer-related proteins pave the way for further exploration and development of these compounds as alternative medicinal agents. In vitro and in vivo studies are warranted to validate their efficacy, particularly in addressing the complexities of different cancer types. Ultimately, this research offers valuable insights into leveraging natural compounds for combating cancer, addressing a critical need in global healthcare.

Formulasi Sediaan Pomade Ekstrak Daun Meniran (Phyllanthus niruri L.) Sebagai Perangsang Penumbuh Rambut Pada Kelinci

Anggun Syafitri — 2024-05-05

Background: Meniran petroleum ether extract 2% which contains lignans and terpenoids can increase hair growth activity by inhibiting 5α-reductase. In addition, the ethanol extract of candlenut seeds from the same family as meniran Flavonoids and phenols can also stimulate hair growth. Previous studies have also shown that quercetin also has activity to increase hair growth. Meniran is also known to contain the flavonoids quercetin, nirurin, rutin, quercitrin, astragalin and galocatechin. So meniran ethanol extract was chosen for this study. Based on a literature search about this research, the researcher was interested in formulating meniran leaf extract pomade (Phyllanthus niruri L.) as a hair stimulant in rabbits (Oryclolagus cunucilus).

Purpose: To determine the formulation of meniran leaf extract pmade (Phyllanthus niruri L.) which is good in stimulating hair growth in rabbits.

Methods: The method used was an experimental study to test the characteristics of pomade preparations with meniran leaf extract concentrations of 5%, 7.5% and 10% with organoleptic, homogeneity, spreadability, pH, irritation and freeze-thaw parameters.

Results: From the results of the research on the characteristic test of pomade preparations on formulations of formula I, formula II and formula III it was found that they fulfilled the characteristics of pomade while F0 did not meet the spreadability requirements.

Conclusion: Among the three formulations, it was found that pomade with formula III had the effectiveness of a good hair growth stimulant and could compete with the positive control.

A FORMULATION OF HAND BODY LOTIO FORMULATION OF HAND BODY LOTION EXTRACT ethanol from lily leaves (Crinum asiaticum L.) AS A SKIN MOISTURIZER

bunga rimta barus — 2024-05-05

Lily leaves (Crinum asiaticum L.) have bioactivity as antioxidants and contain chemical compounds such as glycosides, flavonoids, saponins, tannins and triterpenoids. This study aims to formulate daffodil leaf extract into a hand body lotion dosage form and observe the effectiveness on volunteer skin for 4 weeks. This research was conducted experimentally. Samples were taken from daffodil leaves (Crinum asiaticum L.), then extracted by maceration with 96% ethanol and concentrated using a rotary evaporator. The ethanol extract of daffodil leaves was formulated with concentrations of 5%, 8% and 11%. The preparation evaluation test includes homogeneity, organoleptic, pH, emulsion type, irritation test, and effectiveness test of the preparation to moisturize the skin. The results showed that the ethanol extract of daffodil leaves could be used to make homogeneous grated emulsion preparations which were stable during 4 weeks of storage, pH 7.52-7.25, oil-in-water emulsion type and did not disappear. Any hand cream product that contains narcissus leaf ethanol can increase skin moisture. The composition of the most effective hand and body cream in the treatment of dry skin is a preparation with a concentration of 11% ethanol extract of lily leaves, which increases skin healing by 40.35% and is applied to the skin within 1 month.

FORMULASI DAN EVALUASI SEDIAAN SERUM WAJAH EKSTRAK ETANOL KOMBINASI DARI EKSTRAK KULIT JERUK NIPIS (Citrus aurantiifolia) DAN EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus polyrhizus)

Delisma Simorangkir — 2024-05-05

Background: The skin of the key orange (Citrus aurantiifolia) contains kuersetin, miristin, routinely, tangerine, naringin and hesperine, while the skin of the red dragon fruit (Hylocereus polyrhizus) contains betaalanin, anthocyanin, vitamin a, vitamin a, vitamin e, turnioid, flavonoid, tiamin, niacin, piridoine, kobalamin, carotene, and fitoalbumin. The research was intended to formulate it in a availability of facial serum and then evaluate its quality formula for a better facial serum from 16-4954-1998. Methods : This method of research is experimental in the laboratory by making 4 formulas consisting of F1 as serum bases, F2 ratio EKJN and EKBNM (1:1), F3 ratio EKJN and EKBNM (1:2) ,F4 ratio EKJN and EKBNM (2:1).Results : The results of all the formulas for existing existing face-serum EKJN ethanol and EKBNM viscers show a clear, clear, yellowish color, a gel-based, characteristic and homogenous odor. pH and viscosity scores on each condensed formula. No irritation test on the formula showed irritation to the skin.Conclusion : Based on this, it can be concluded that the combined ethanol extract of lime peel extract and red dragon fruit peel extract can be formulated into a facial serum cosmetic preparation and meets the quality requirements according to SNI.

Uji Efektivitas Formulasi Sediaan Lipstik Menggunakan Bahan Pewarna Alami Dari Ekstrak Etanol Gambir (Uncaria Gambir (Hunteri)Roxb.) Dan Ekstrak Etanol Buah Stroberi (Fragaria Vesca).

Delisma Simorangkir — 2024-05-05

Abstract: Lipstick is a form of lip coloring preparation which is a cosmetic preparation used to color the lips, to improve aesthetics in facial make-up. Lipstick preparations are available in various forms such as liquid, crayon, liptin, lipbam and cream. Lipstick consists of a coloring agent dispersed in a carrier made from a mixture of wax and oil, in such a composition as to provide the desired melting temperature and viscosity. The aim of the research is to determine the physical stability of lipstick preparations made from gambier extract and strawberry fruit extract as coloring agents. Sampling was carried out using a purposive sampling method, namely a random sampling methodology. The samples used were Gambir (Uncaria Gambir (Hunteri) Roxb.) and Ethanol Extract of Strawberries (Fragaria Vesca). then extracted by maceration using 96% ethanol solvent, concentrated by rotary. The combination of gambier ethanol extract and strawberry ethanol extract was formulated with a concentration of F1: 5%:5%, F2 :10%:10%. F315%:15%. Examination of the quality of the preparation includes organoleptic, homogeneity, pH, irritation, preference and continues with statistical analysis tests using One Way Anova. The results of normality tests with the Shapiro-Wilk test and homogeneity test, produce a value for each data > 0.05, so the data is normally distributed. The results of the One Way Anova test for each formulation group showed that the Sig value was <0.05, so the formulations had a significant difference.

HUBUNGAN PENGETAHUAN DAN SIKAP MASYARAKAT KECAMATAN CAKUNG JAKARTA TIMUR TERHADAP PENGGUNAAN DAN RESISTENSI ANTIBIOTIK

Numlil Khaira Rusdi — 2024-05-05

Antibiotic resistance is one of the serious problems that are being faced today. Low levels of knowledge and poor public attitudes about antibiotic use can trigger resistance. This study aims to determine the level of knowledge, attitudes, and relationships between the level of knowledge and attitudes of the community about antibiotic use and resistance in Cakung District, East Jakarta for the July-August 2023 period. The design of this study was descriptive with cross sectional method. The sampling technique uses purposive sampling. The source of data in this study is primary data in the form of knowledge questionnaires and attitudes about antibiotics. Knowledge is categorized with high and low, while attitude is categorized with positive and negative. The results showed that as many as 400 respondents met the inclusion and exclusion criteria. The characteristics of public knowledge about antibiotics showed that 65.3% of respondents had high knowledge and 34.7% had low knowledge. As many as 61.0% of respondents had a positive attitude and 39% had a negative attitude towards the use of antibiotics and resistance. The results of the bivariate analysis showed that there was a significant relationship between the level of knowledge and people's attitudes towards antibiotic use and resistance (P<0.000). The higher the level of knowledge of the community, the more positive the attitude of the community towards the wise use of antibiotics.

FORMULASI SEDIAAN KRIM EKSTRAK ETANOL JAHE MERAH (Zingiber Officinalis var.Rubrum) SEBAGAI ANTIDIABETIC FOOT

Anniza faradina — 2024-05-05

Red ginger is used as a medicinal raw material because it contains 3% oleoresin which has anti-inflammatory, antioxidant, and anti-bleeding properties. In addition, red ginger contains volatile oil (2.58%-2.72%). Red ginger has long been used as medicine to treat a wide range of diseases, including preventing Staphylococcus aureus. Diabetic foot is caused by the pathogenic bacteria Staphylococcus aureus. The purpose of this study was to use experimental research to create a cream formula with ethanol extract of red ginger. Previous research shows that red ginger extract (Zingiber Officinalis Var. Rubrum) has an 80% inhibition zone of 13.11 mm against Staphylococcus aureus bacteria. It can be concluded that Formula 3 (propylene glycol 15%, TEA 3%, oleum rosae drops, cetyl alcohol 3%, and distilled water 50 ml) can be used to make red ginger ethanol extract cream as antidiabetic foot cream.

COMPARISON ANTIOXIDAN ACTIVITY OF RED GINGER (Zingiber officinale var. rubrum) ETANOL EXTRACTION BY MASERATION AND DIGESTI MASERATION METHODS

Jesica Merry — 2024-05-05

The red ginger plant (Zingiber officinale variety rubrum) is a common plant in our surroundings that is used to cure a number of degenerative diseases as well as pain management, antipyretic, and anti-inflammatory conditions. Volatile oil, non-volatile oil and starch substances are part of red ginger. The volatile oil or volatile oil gives ginger its characteristic odor, and the non-volatile oil or oleoresin gives it its bitter taste. Oleoresin, which consists of resin, gingerol, and shogaol, It is an antioxidant needed by the body to prevent free radicals from forming and being harmful to the body. The reason for this is to determine the antioxidant content of red ginger. The extraction methods used were maceration with the process of soaking the material using nonpolar solvents without heating and digestion maceration or kinetic maceration (continuous stirring) using weak heating at 40-50°C. Very strong antioxidant activity was obtained where digestion maceration with an IC50 value of 7,30 was stronger than maceration with an IC50 of 11,90 because heating in digestion maceration opens the tissue in red ginger so that active compounds are extracted out.

TESTING FOR ANTIBACTERIAL ACTIVITY OF FRUIT SKIN ETHANOL EXTRACT DUKU (Lansium domesticum Corr) AGAINST BACTERIA Salmonella Typhi

Suci Wulandari — 2024-05-05

Salmonella typhimurium bacteria is the cause of typhoid fever. One of the herbal plants that can be used as an antibacterial drug is duku fruit peel (Lansium domesticum Corr). Phytochemical tests were carried out on duku fruit peel extract which was soaked in 96% ethanol solvent. The aim of this test is to identify secondary metabolites found in duku fruit skin. There are alkaloids, flavonoids, saponins, tannins and triterpenoids in the ethanol extract of duku fruit peel. This study involved four treatment groups with extract concentrations of 25 percent, 50 percent, and 75 percent, along with a positive control (chloramphenicol) and a negative control (distilled water). With inhibition zone diameters of 10.22 mm, 11.94 mm, and 13 mm, the ethanol extract of duku fruit peel showed antibacterial activity against Salmonella enterica bacteria. The results of univariate data analysis showed that the ethanol extract of duku fruit peel showed antibacterial activity at 25%, 50% and 75%. The results of univariate data analysis showed that the ethanol extract of duku fruit peel showed antibacterial activity against Salmonella typhi bacteria. In addition, the bacterial concentration increases with the width of the inhibition zone.