Jurnal Penelitian Farmasi Dan Herbal

ANALISIS KADAR TANIN BERBAGAI JENIS TEH HITAM DAN TEH HIJAU KHAS KOTA PAGARALAM SEBAGAI ANTIOKSIDAN MENGGUNAKAN METODE SPEKTROFOTOMETER UV-VIS

2025-05-15T11:44:24SE Asia Daylight Time

The plant known as tea (Camellia sinensis L.) is widely grown in Indonesia. The shoots of young tea leaves are brewed into a health drink. This research was carried out with the aim of determining the tannin content of green tea and black tea as well as their antioxidant activity using the UV-Vis spectrophotometer method. Thick extracts from black tea and green tea from qualitative and quantitative test results showed the presence of tannin compounds with tannin levels in the samples obtained were T1 Black tea (CTC Tea) Slopes of Mount Dempo 0.070, T2 Green tea (PTPN 7) Pagaralam tea typical of South Sumatra 0.061, T3 Green tea (PTPN 7) Gunung Dempo 0.028, T4 Black Tea (CTC Tea) Pucuk Gunung Dempo 0.059, and antioxidant activity was tested using 2,2 diphenyl-1-picrylhydrazyl (DPPH). Black tea and green tea extracts have antioxidant activity with a value of IC50 (Inhibition Concentration 50). T1 has very strong antioxidant activity (13.89%), followed by code T2, the antioxidant activity is also very strong (3.67%), code T3 has very strong antioxidant activity. strong (2.02 %), and T4 code moderate antioxidant activity (6.02 %). Black tea and green tea extracts contain high levels of tannin and have very strong antioxidant activity.

Formulasi Dan Uji Stabilitas Sediaan Lip Tint Kombinasi Ekstrak Kulit Buah Naga (Hylocereus Polyhizu) Sebagai Pewarna Dan Kulit Jeruk Nipis (Citrus Aurantifolia) Sebagai Inhibitor Tirosinae

2025-05-15T11:52:07SE Asia Daylight Time

Kulit buah naga merah (Hylocereus polyrhizus) dapat digunakan untuk menetralisir radikal
bebas dan dimanfaatkan sebagai pewarna alami. memiliki daya antioksidan tang tinggi. Kulit
jeruk nipis (Citrus aurantifolia) mempunyai manfaat sebagai antioksidan dan mengandung
enzim tirosinase. Tujuan penelitian ini untuk mengetahui ekstrak kulit buah naga merah
(Hylocereus polyrhizus) dengan kombinasi ekstrak kulit jeruk nipis (Citrus aurantifolia) dalam
pembuatan sediaan lip tint dan stabilitasnya. Kulit buah naga merah (Hylocereus polyrhizus)
dibuat sediaan Lip Cream menggunakan variasi konsentrasi ekstrak pada 10%, 15%, 20%
sedangkan kulit jeruk nipis (Citrus aurantifolia) 40% untuk semua konsentrasi. Penelitian ini
menggunakan metode eksperimen, uji secara fisika kimia, cycling test dan menguji antioksidan
menggunakan metode DPPH. Hasil penelitian diperoleh bahwa ekstrak kulit buah naga merah
(Hylocereus polyrhizus) dan ekstrak kulit jeruk nipis (Citrus aurantifolia) dapat dibuat sediaan
lip tint karena memenuhi uji stabilitas fisik. Hasil penelitan menunjukkan pada Formula I
memiliki nilai IC50 77,77 μg/mL, formula II memiliki nilai IC50 55,58 μg/mL, formula III
memiliki nilai IC50 70,63 μg/mL, dan formula (-) tanpa ekstrak memiliki nilai IC50 38,91.
Sediaan lip tint ekstrak kulit buah naga merah (Hylocereus polyrhizus) dan ekstrak kulit jeruk
nipis (Citrus aurantifolia) memiliki aktivitas antioksidan.

ANALISIS ANTIOKSIDAN PADA KAPSUL HABBATUSSAUDA (Nigella sativa L.) DENGAN METODE DPPH SECARA SPEKTROFOTOMETRI UV-Vis Tahun 2022

2025-05-15T11:55:46SE Asia Daylight Time

Background: One of the plants that is often used as a medicinal plant is Black Seed. Black Seed in Indonesia is called of black cumin. Main contains of black cumin (Nigella sativa L.) are Thymoquinone, Dithymoquinone, Thymohydroquinone, and Thymol as antioxidants.. Purpose: of this research to test the antioxidant activity contained in Black Seed capsules. Black Seed capsules were tested for weight uniformity, and phytochemical screening. This research Method : Then the Black Seed capsules were tested for antioxidant activity using the DPPH method using a Spectrophotometer UV-Vis at a wavelength of 516 nm, then the value of IC50 was determined in the sample and for comparison, Vitamin C as a comparison. Results: results of uniformity test of capsule weights A1 = 2.72%, A2 = 2.54%, B = 2.00%. The results of phytochemical screening of Black Seed capsule powder contain alkaloids, flavonoids, tannins, saponins, and steroids. The results of the antioxidant activity test using the DPPH method showed that Black Seed capsules with methanol solvent had antioxidant activity with an Inhibitory Concentration (IC50) of 97.635 µg/ml categorized in a class of strong antioxidant and vitamin C as a comparison has IC50 of 4.397 µg/mL with a very strong category.. Conclusion: so that vitamin C has a stronger antioxidant activity than black seed capsules. The results showed that Black Seed capsules contained antioxidants and had strong antioxidant activity.

UJI EFEKTIVITAS EKSTRAK ETANOL DAUN GAGATAN HARIMAU (Vitis gracilisWall) TERHADAP PENAMBAH STAMINA PADA MENCIT JANTAN

2025-05-15T11:56:30SE Asia Daylight Time

Stamina is the ability of human endurance to withstand fatigue within a certain time limit, where activities are carried out with high intensity and always use energy that can be treated with traditional medicine derived from plants. One example of plants that can increase stamina is tiger gagatan leaves which contain flavonoids that can increase the motor activity of mice by inhibiting the absorption of calcium ions entering the sarcoplasmic reticulum after that with the obstacle causing high calcium ion levels in sarcoplasm and containing tonic effects. The purpose of the study was to determine the effect of giving tiger gagatan leaf extract in increasing stamina compared to caffeine. This research was conducted by experimental method, samples were extracted maceration using 96% ethanol solvent and concentrated with a rotary evaporator. Using 25 mice and divided into 5 groups. The control group was negative CMC-Na 0.5%, the control group positive for caffeine 0.13mg/kgBB, EDGH with a dose of 50mg/kgBB, EDGH with a dose of 100mg/kgBB, EDGH with a dose of 200mg/kgBB. Then observed the endurance time of mouse stamina and calculated the average physical endurance time of mice by swimming method. From the results of the study that the EDGH dose of 200mg/kgBB had optimal effectiveness close to the positive control group with swimming endurance time of 52.18 minutes, while EDGH with a dose of 100mg / kggBB showed a physical endurance time of mice of 49.07 minutes, and EDGH 50mg / kg BB showed a physical endurance time of mice of 48.24 minutes. So it can be concluded that tiger gagatan leaf extract at a dose of 200mg/kgBB has an effectiveness equivalent to caffeine in increasing stamina against male white mice.

PENGEMBANGAN FACEMIST KOMBINASI EKSTRAK DAUN BIDARA (Ziziphus spina cristi (L.) Desf) DAN DAUN BENALU DUKU (Dendrophthoe pentandra (L.) Miq ) SEBAGAI ANTIOKSIDAN PADA KULIT WAJAH

2025-05-15T11:56:54SE Asia Daylight Time

The skin needs antioxidant compounds that can ward off free radicals caused by several factors, one of which is air pollution. Bidara leaves (Zizipus spina Cristi (L) Desf) and benalu duku leaves (Dendrophthoe pentandra (L.) Miq) contain flavonoid compounds that function as antioxidants that can ward off free radicals. This study aims to formulate bidara leaf extract and benalu duku leaf into the form of Facemist preparation and determine the best Facemist product formula with the addition of bidara leaf extract, benalu leaf, and a combination of two extracts through antioxidant activity parameters. The antioxidant activity test was carried out using the DPPH (1,1-dipenyl-2-picrylhydrazyl) method. The Facemist sample was formulated into a Facemist with concentration variations: F1 : EEDB 5%, F2 : EEDBD : 5%, F3 : EEDB : 2.5% EEDBD 2.5%, F4 : EEDB : 5% EEDBD : 5%, F5 : EEDB : 10% EEDBD : 10%. Facemist preparations are eval_uated for their physical characteristics, namely organoleptic test, homogeneity test, pH test, viscosity test, dry time test, irritation test. The results showed that Facemist was a combination of bidara leaf extract and benalu duku leaf homogeneous, pH <7, had a viscosity value of <500 cps, a good drying time of <5 minutes and did not cause irritation to the skin. The formulation of Facemist preparation that has the best antioxidant activity value is F5 with antioxidant activity (IC₅₀) of 58.33 ppm in the strong category.

UJI AKTIVITAS ANTIBAKTERI FORMULASI SEDIAAN GEL HAND SANITIZER EKSTRAK ETANOL DAUN PALA (Myristica fragrans Houtt) TERHADAP BAKTERI Staphylococcus epidermidis DAN Streptococcus sp

2025-05-15T11:30:26SE Asia Daylight Time

The pala leaves contain alkaloids, flavonoids, saponins, tannins, and steroids which high antiseptic and antibacterial effects. The goal of the research make a formulation of hand sanitizer gel with etanol extreact by pala leaves (Myristica fragrans Houtt) as the antibacterial againt the Staphylococcus epidermidis and Streptococcus sp bacteria with CMC-Na base. Pala leaves hand sanitizer gel with etanol extract was formulation I 5%, formulation II 10%, and formulation III 15%. The method used in this study was antibacterial testing method used is the disc diffusion technique. Hand sanitizer gel is tested for the physical properties including organoleptic test, pH test, homogeneity test, and spreadability test. Hand sanitizer gel which has antibacterial activity against the Staphylococcus epidermidis and Streptococcus sp, bacteria is second (III) formulation in with concentration 15% that has an inhibition zone of 17 mm on bacteria Staphylococcus epidermidis and 16,86 mm on bacteria Streptococcus sp, mean while in formulation II with concentration 10% that has an inhibition zone of 13,16 mm on bacteria Staphylococcus epidermidis ang 13,16 on bacteria Streptococcus sp, mean while in formulation I with concentration 5% that has an inhibition zone of 12,02 mm on bacteria Staphylococcus epidermidis and 12,16 mm on bacteria Streptococcus sp, and the last positive control (nuvo gel hand sanitizer) that has an inhibition 17,73 mm on bacteria Stahylococcus epidermidis and 17,69 mm on bacteria Streptococcus sp. The final results of the research indicate, there is an ability of hand sanitizer gel pala leaves (Myristica fragrans Houtt) extract to prevent the growth of Staphylococcus epidermidis and Streptococcus sp bacteria with concentration of 15% hand sanitizer gel preparation.

UJI EFEKTIVITAS EKSTRAK ETANOL DAUN RARU (Cotylelobium Melanoxylon) SEBAGAI ANTIINFLAMASI TERHADAP EDEMA KAKI TIKUS YANG DI INDUKSI KARAGENAN TAHUN 2023

2025-05-15T11:58:17SE Asia Daylight Time

Flavonoids contained in raru leaves (Cotylelobium Melanoxylon) have anti- inflammatory activity. This study aims to determine the anti-inflammatory effect of raru leaf extract (Cotylelobium Melanoxylon) on white rats. Tests were carried out by producing edema on rat feet induced by 1% carrageenan. The anti- inflammatory effect test was divided into 5 treatment groups, each treatment group consisted of 3 rats, group 1 (negative control) was given CMC 0.5% Na suspension, group 2 (positive control) was given 2.25 mg/day diclofenac Na suspension. kgBB, group 3 raru leaf extract suspension dose of 50 mg/kgBB, group 4 raru leaf extract dose 100 mg/kgBB, and raru leaf extract dose of 150 mg/kgBB. The extract used the percolation method, with 70% ethanol solvent, measurement of inflammation volume was measured using a pletistometer, carried out for 180 minutes with an interval of 30 minutes after being induced with 1% carrageenan. From the results of this study, high doses of raru leaf extract have an anti-inflammatory effect. Data were analyzed using one way ANOVA. the data of this study that a dose of 150 mg/kgBB, is the dose with the most effect which is almost equivalent to the positive control group as an anti- inflammatory.

FORMULASI SEDIAAN GEL EKSTRAK ETANOL DAUN BIDARA (Ziziphus mauritiana L) SEBAGAI PENYEMBUHAN LUKA BAKAR TERHADAP TIKUS PUTIH JANTAN

2025-05-15T11:58:56SE Asia Daylight Time

Burn wound treatment is still carried out simply and is generalized with a certain pattern for various wound conditions and problems. One of the natural ingredients (herbs) that has an effect as a medicine for burns is the Bidara plant (Zizipus mauritiana L.), which has antibacterial, anti-viral, antiseptic properties and its function in regenerating and repairing skin cells. This research is a type of experimental research. Sampling was carried out purposively. The research procedure consisted of several stages, namely making reagents, phytochemical screening tests, and examining the characteristics of the ethanol extract. The research procedure consisted of several stages, namely making reagents, phytochemical screening tests, and examining the characteristics of the ethanol extract. The results of microscopic examination of sapodilla leaf simplicia powder showed the presence of stomata, tissue cells, parenchymal tissue and normal hair. In the One Way Anova results table for total burn wound healing after treatment, it shows a sig value <0.05 with the burn wound healing value from day 1 showing a significant value: 0.000. This shows that there is a significant difference in the value of burn wound healing from day 1. 1st to 14th day. The identification results of Bidara leaf extract (Zizipus mauritiana L.) showed that it positively contained secondary metabolite compounds, namely alkaloid compounds, flavonoid compounds, tannin compounds, saponin compounds and terpenoid compounds. The ethanol extract gel preparation of bidara leaves is less effective than bioplacenton for healing burns.

Penelitian Uji Aktivitas Antibakteri Pseudomonas Aeruginosa Pada Param Karo Sebagai Antidiabetic Foot

2025-05-15T11:59:27SE Asia Daylight Time

Param Karo is a traditional medicinal herb that is added with rice flour (Oryza sativa) as a solidifier. Param Karo has many properties, especially as an alternative treatment for fever, flatulence, and various other conditions. Param Karo is used by repeatedly applying it on the body to help normalize body temperature. The purpose of this study was to determine the activity of param Karo against Pseudomonas aeruginosa bacteria as the cause of diabetic foot wounds, as well as to identify the optimal concentration of param Karo needed to achieve significant antibacterial activity. Extraction was carried out using 96% ethanol solvent, and antibacterial activity testing was carried out by disc diffusion method on Pseudomonas aeruginosa bacteria with 3 concentrations namely, 25%, 50%, 75%. The results showed that the ethanol extract of Param Karo had the most significant antibacterial activity at a concentration of 75% with the formation of a clear zone around the disc. Ciprofloxacin was used as positive control, while DMSO 10% as negative control.

Skrinning Resep Interaksi Obat Pasien Diabetes Melitus Dan Hiperkolestrol Periode Oktober S.D Desember 2023 Di Rumah Sakit Advent Medan

2025-05-15T12:00:04SE Asia Daylight Time

Prescription screening is done to prevent the presence or absence of errors in drugs. Prescription screening is a stage in pharmaceutical services carried out by pharmacists who provide pharmaceutical services and pharmaceutical personnel can receive prescriptions from patients. This study aims to conduct prescription screening for drug interactions in patients with diabetes and hypercholesterolemia in the period October to December 2023. Patients with diabetes mellitus and hypercholesterolemia often receive combination therapy, which increases the risk of drug interactions. Lack of understanding of the potential for drug interactions can result in patient safety risks. Therefore, this study focuses on prescription screening to identify and analyze possible drug interactions

FORMULASI DAN UJI EFEKTIVITAS SEDIAAN GEL EKSTRAK ETANOL DAUN SAMBUNG RAMBAT (Mikhania mikrantha) SEBAGAI ANTIINFLAMASI PADA TIKUS PUTIH JANTAN

2025-05-15T12:00:46SE Asia Daylight Time

Background: Inflammation is a normal response due to the immune to eliminate pathogens, prevent the spread of tissue damage and repair damaged tissue due to pathological symptoms of a disease, Objective: To determine the concentration that provides effectiveness as an anti-inflammatory against male white rats induced with 1% carrageenan. . Methods: The vines were extracted using 96% ethanol as a solvent. 15 wistar rats were adapted for seven days. The rats were randomly divided into 5 groups. Group I (negative control) based on gel, group II (positive control) voltaren gel, group III ethanolic extract of vines with a concentration of 5%, group IV of ethanolic extract of vines of leaves 10%, group V of ethanolic extract of vines of leaves 15%. All treatment groups were sublanted with 1% carrageenan. Edema in rat feet was measured at 30 minutes to 180 minutes. Data analysis used the one way ANOVA method. Results: from the result of the study show that each treatment group experienced a reduction in inflamasi,in the 5 treatment groups, the best reduction in inflmation was the consentration 15% wich was the best compared to voltaren gel in reducing inflamation,Conclusion: the ethanolic extract of vines has an almost equeval__ent effect the drug voltaren but the drug voltaren is more effegtive reducing inflamation.

PENETAPAN KADAR VITAMIN C PADA DAGING BUAH CABAI MERAH KERITING (Capsicum annum L.) YANG BEREDAR DI PASAR BUAH BERASTAGI KABUPATEN KARO MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS

2025-05-15T12:01:11SE Asia Daylight Time

Background: Vitamins are complex compounds that are needed by the body that function to help regulate or regulate the body's metabolic processes. One of the vitamins needed by the body is vitamin C. Vitamin C is a nutrient that acts as an antioxidant and is effective in overcoming free radicals that can damage cells or tissues, including protecting the lens from oxidative damage caused by radiation. Vitamin C or ascorbic acid is one of the vitamins that is soluble in water, easily oxidized, and sensitive to light stimulation. One of the plants that contain vitamin C is curly red chili. Red chilies have different levels of spiciness. Determination of vitamin C levels in red chili was carried out by UV-Vis spectrophotometry. This study aims: to determine the levels of vitamin C contained in the flesh of curly red chili (Capsicum annum L.) circulating in the Berastagi fruit market, Karo Regency. Methods: The sample used was curly red chili meat obtained from Berastagi fruit market, Karo Regency. The test was carried out by UV-Vis spectrophotometry with a wavelength of 296 nm. Results: The results of research conducted by UV-Vis spectrophotometry obtained an average level of vitamin C in the flesh of red curly chilies of 5.4689 mg/g. Conclusion: The results of the study showed that the flesh of curly red chilies had vitamin C.

SKRINNING RESEP INTERAKSI OBAT PASIEN DIABETES MELITUS DAN GAGAL GINJAL PERIODE OKTOBER S.D DESEMBER 2023 DI RUMAH SAKIT RASYIDA MEDAN

2025-05-15T12:02:10SE Asia Daylight Time

Prescription screening is a critical phase in pharmaceutical services conducted by
pharmacists and pharmaceutical technical personnel upon receiving a
prescription from a patient. This study specifically aims to eval_uate the outcomes
of prescription screening based on administrative and pharmaceutical conformity
analysis at Rasyida Hospital, Medan. The research method employed is a
descriptive cross-sectional approach with a retrospective design, collecting data
from the period of October to December 2023. The study reveals that
administrative eval_uations in prescription screening include several essential
elements such as the patient's name, age/date of birth, address, body weight,
the prescribing doctor's name and registration number (SIP), hospital address,
doctor’s initials, practice phone number, and the prescription date. On the other
hand, pharmaceutical review focuses on elements such as the name of the
medication. With the rising morbidity rate and increased medication use in
hospitals, addressing drug-related problems—particularly those stemming from
inappropriate medication use—has become more urgent. Prescription
assessment plays a key role in preventing such issues. This study aims to
identify the elements with the highest level of incompleteness or prescribing
errors. Incomplete prescriptions are a major trigger for medication errors,
making prescription screening by pharmacists across healthcare facilities—such
as hospitals, community health centers, and pharmacies—a critical practice.
Screening encompasses both administrative and pharmaceutical aspects,
highlighting the essential role of pharmacists in mitigating potential health risks
for patients.