FORMULASI SEDIAAN KAPSUL DAN UJI EFEKTIFITAS EKSTRAK ETANOL KOMBINASI DAUN KECOMBRANG (Etlungera elatior) DAN DAUN PEPAYA (Carica papaya L) SEBAGAI ANTIHIPERLIPIDEMIA PADA TIKUS PUTIH JANTAN (Rattus norvegicus)
DOI:
https://doi.org/10.36656/cd0jkk86Keywords:
Capsules, kecombrang leaves, papaya leaves, hyperlipidemia, simvastatinAbstract
Hyperlipidemia is a lipid metabolism disorder which is characterized by an increase in total cholesterol levels in the blood which can be treated with traditional medicine from plants. One example of plants that can be used are kecombrang leaves and papaya leaves which contain flavonoids that work by reducing HMG-CoA reductase levels which will have the effect of reducing cholesterol levels in the body. Saponins lower triglyceride levels in the blood, by influencing the formation of fatty acids in the liver.Tannins prevent the oxidation of cholesterol. This study was conducted to determine the effect of the ethanol extract of the combination of kecombrang leaves and papaya leaves in reducing blood hyperlipidemia levels compared to simvastatin. An experimental study to examine hyperlipidemia levels using the CHOD-PAP method used 21 rats induced with a high-fat diet and divided into 7 groups. namely the negative group (CMC Na 0.5%), the positive group (simvastatin), the single kecombrang extract group 140mg/kgBW, the papaya single extract group 120mg/kgBW, the combined extract 70mg/kgBW and 60mg/kgBW, the combined extract 140mg/kgBW and 120mg/kgBW, and a combination extract of 210mg/kgBW and 180mg/kgBW. The data were analyzed using the one way ANOVA method. The results showed that the most effective treatment was simvastatin and a combination of 210mg/kgBW and 180mg/kgBW. The results of group data analysis had an effect on cholesterol reduction because the sig value was > 0.05. Based on ANOVA analysis, one of the seven most effective treatments was simvastatin, f5, f4, f3, f2 f1 and cmc na 0.5%
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