UJI EFEK ANTIDIARE EKSTRAK RIMPANG KUNYIT (Curcuma domestica val.) PADA MENCIT JANTAN

Abstract

Objectives : The purpose of this study to determine the effect and dose of effective use of rhizome extract of turmeric as antidiarrhea in male mice induced castor oil and the use of rhizome extract of turmeric equivalent to Loperamid HCl.

Method : This research method is carried out experimentally with the research stages of sample preparation,  sample  characterization,  simplicia screening,  preparation  of  extracts, preparation  of  animal  experiments  and  testing  of  antidiarrheal  effects  in  experimental animals.

Results : The results showed that the results of phytochemical screening of simplicia powder and turmeric rhizome extract contained flavonoids and tannins. SPSS statistical test results (statistical package for the social science) continued with defference test of Duncan average, the duration of the occurrence of diarrhea showed that the control group of Loperamid HCl dose 1 mg/kg bw gave significant effect on turmeric rhizome extract at doses of 40 mg/ kg bw and doses 80 mg/kg bw. The shorter the time of diarrhea, the stronger the antidiarrheal effect.

Conclusion :  Turmeric rhizome extract dose 20 mg/kgbw showed that dose 20 mg/kgbw has antidiarrhea effect more than lower than Loperamid HCl dose 1 mg/kg bw. Turmeric rhizome extract dose 40 mg/kg bb has same effect with Loperamid HCl dose 1 mg/kgbb. And turmeric rhizome extract dose 80 mg/kgbb has effect more potencial that Loperamid HCl dose 1mg/kg bw. There is a relationship between the size of the dose with the antidiarrheal effect that occurs.