FORMULASI DAN EVALUASI SEDIAAN SERUM WAJAH EKSTRAK ETANOL KOMBINASI DARI EKSTRAK KULIT JERUK NIPIS (Citrus aurantiifolia) DAN EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus polyrhizus)
Keywords:
extract of lemon peel, extract of red dragon fruit, serum face.
Abstract
Background: The skin of the key orange (Citrus aurantiifolia) contains kuersetin, miristin, routinely, tangerine, naringin and hesperine, while the skin of the red dragon fruit (Hylocereus polyrhizus) contains betaalanin, anthocyanin, vitamin a, vitamin a, vitamin e, turnioid, flavonoid, tiamin, niacin, piridoine, kobalamin, carotene, and fitoalbumin. The research was intended to formulate it in a availability of facial serum and then evaluate its quality formula for a better facial serum from 16-4954-1998. Methods : This method of research is experimental in the laboratory by making 4 formulas consisting of F1 as serum bases, F2 ratio EKJN and EKBNM (1:1), F3 ratio EKJN and EKBNM (1:2) ,F4 ratio EKJN and EKBNM (2:1).Results : The results of all the formulas for existing existing face-serum EKJN ethanol and EKBNM viscers show a clear, clear, yellowish color, a gel-based, characteristic and homogenous odor. pH and viscosity scores on each condensed formula. No irritation test on the formula showed irritation to the skin.Conclusion : Based on this, it can be concluded that the combined ethanol extract of lime peel extract and red dragon fruit peel extract can be formulated into a facial serum cosmetic preparation and meets the quality requirements according to SNI.
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References
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Mahargyani W. Identifikasi senyawa dan uji aktivitas antioksidan ekstrak etanol kulit buah naga merah (Hylocereus polyrhizus). Pinlitamas 1; 2018. p.614–22.
Manihuruk FM, Suryati T, Arief II. Effectiveness of the red dragon fruit (Hylocereus polyrhizus) peel extract as the colorant, antioxidant, and antimicrobial on beef sausage. Media Peternak. 2017;40(1):47–54.
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Marjoni, Riza. 2016. “Dasar-Dasar Fitokimia Untuk Diploma III Farmasi.” Jakarta: Cv.Trans Info Media 39–43.
Mukhriani, M., Nurlina, N., & Baso, F. F. (2014). Uji aktivitas antimikroba dan identifikasi ekstrak buah sawo manila (Achras zapota L.) terhadap beberapa mikroba patogen dengan metode difusi agar. Jurnal farmasi UIN Alauddin Makassar, 2(2), 69-74
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Ning, D., Baki, A., Scherb, T., Song, J., Fantin, A., Liu, X., ... & Bouwmeester, H. J. (2019). Influence of A-site deficiency on structural evolution of Pr2-xNiO4+ δ with temperature. Solid state ionics, 342, 115056.
Noor, M. I., & Yufita, E. (2016). Identification Content of the Red Dragon Fruit Extract Skin Using Fourier Transform Infrared (FTIR) and Phytochemistry. Journal of Aceh Physics Society, 5(1), 14-16..
Nuari, Ris Ayu and Rachma Putri Maulida. 2020. “Uji Aktivitas Antioksidan Gel Ekstrak Kulit Jeruk Nipis ( Citrus Aurantifolia S ) Dengan Metode DPPH Dan METODE ABTS Antioxidants Activity Test of Lime Peel Extract Gel ( Citrus Aurantifolia S ) with DPPH and ABTS Methods.” 4(1):42–52.
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Pratiwi, D., Suswati, I., dan Abdullah, M. 2013. Efek Antibakteri Ekstrak Kulit Jeruk Nipis (Citrus aurantifolia)Terhadap Salmonella thypii Secara In Vitro. Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Vol. 9 No.2.
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Septiani, R., Widyaningsih, S., & Iqomh, M. K. B. (2019). Tingkat perkembangan anak pra sekolah usia 3-5 tahun yang mengikuti dan tidak mengikuti Pendidikan Anak Usia Dini (PAUD). Jurnal Keperawatan Jiwa, 4(2), 114-125.
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Sholikhah, M. A., & Apriyanti, R. (2020). Formulasi Dan Karakterisasi Fisik Masker Gel Peeloff Ekstrak Lengkuas (Alpinia galanga,(L.) Sw). Jurnal Ilmu Farmasi dan Farmasi Klinik, 16(02), 99-104.
Simangunsong, W. S. (2019). Formulasi Sediaan Masker Gel Dari Ekstrak Mentimun (Cucumis Sativus L.) Kombinasi Ekstrak Buah Lemon (Citrus Limon L. Burm. Fil.) (Doctoral Dissertation, Institut Kesehatan Helvetia).
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Sutejo, A. M., Priyatmojo, A., & Wibowo, A. (2008). Identifikasi morfologi beberapa spesies jamur Fusarium. Jurnal Perlindungan Tanaman Indonesia, 14(1), 7-13.
Syarifah, S., Elfita, E., Widjajanti, H., Setiawan, A., & Kurniawati, A. R. (2021). Diversity of endophytic fungi from the root bark of Syzygium zeylanicum, and the antibacterial activity of fungal extracts, and secondary metabolite. Biodiversitas Journal of Biological Diversity, 22(10).
Thakre, A. D., 2017, Formulation and development of de pigment serum incorporating fruits extract. International Journal of Innovative Science and Research Technology, 2(12): 330–382.
Tundis, R., F., Menichini, M., Bonesi, F., Conforti, G., Statti, F., Menichini, M., R., Loizzo. 2013. Antioxidant and Hypoglycaemic activities and their relationship to phytochemicals in capsicum annuum cultivars during fruit development. LWT-Food Science and Technology. 53(1):370-377.
Vijayakumar R, Abd Gani SS, Zaidan UH, Halmi MIE, Karunakaran T, Hamdan MR. Exploring the potential use of Hylocereus polyrhizus peels as a source of cosmeceutical sunscreen agent for its antioxidant and photoprotective properties. Evidence-based Complementary and Alternative Medicine. 2020;2020.
Woo, K., Wong, F. F., dan Chua, H. C. 2011. Stability of the Spray-Dried Pigment of Red Dragon Fruit Hylocereus polyrhizus (Weber) Britton and Rose] as a Function of Organic Acid Additives and Storage Conditions. Philipp Agric Scientist Vol. 94 No. 3, 264-269.
Wu, L.C., H.W. Hsu., Y.C. Chen., C.C. Chiu., Y. I. L. dan A. H. (2006) ‘Antioxidant And Antiproliferative Activities of Red Pitaya’, Food Chemistry, Vol. 95, pp. 319–327.
Andarina, R., & Djauhari, T., 2017, Antioksidan dalam Dermatologi. Jurnal Kedokteran Dan Kesehatan, 4(1): 39–48.
Aprilliani, A., Supriyanta, J., & Badriah, L. (2022). Formulasi Dan Uji Efektivitas Antioksidan Handbody Lotion Ekstrak Etanol 70% Buah Mentimun (Cucumis Sativus L.) Dengan Metode DPPH. Jurnal Farmagazine, 9(1), 20-28.
Astarini, F.N.P., Burhan, R.Y.P., Yulvi, Z. 2010. Minyak Atsiri Dari Kulit Buah Citrus grandis, Citrus aurantium (L.) dan Citrus aurantifolia (rutaceae) sebagai Senyawa Antibakteri Dan Insektisida. Prosiding KIMIAFMIPA ITS, Surabaya.pp.217
Auliasari, N., Najihudin, A. and Restuny, E., 2019. Pemanfaatan Limbah Kulit Jeruk Nipis (Citrus aurantifolia) Dalam Formula Sediaan Gel Sebagai AntiWrinkle. Jurnal Ilmiah Farmako Bahari, 10(2), pp.171-182
Departemen Kesehatan RI, 1995, Farmakope Indonesia. Edisi IV. Direktorat Jenderal Pengawas Obat dan Makanan, Jakarta.
Depkes RI, 1986, Sediaan Galenik, 2 &10, Departemen Kesehatan RI, Jakarta.
Ditjen pom, Ulaen, S. P., Banne, Y., & Suatan, R. A. (2012). Pembuatan salep anti jerawat dari ekstrak rimpang temulawak (Curcuma xanthorrhiza Roxb.). Jurnal Ilmiah Farmasi (JIF), 3(2), 45-49.
Ditjen POM. 1986. Sediaan Galenik. Departemen Kesehatan Republik Indonesia. Jakarta.
Erlinda wati dan Dr. Safrida. 2018. Potensi Antioksidan Sebagai Antidiabetes. Syia kuala university press: Aceh.pp.94
Febriyenti, F., Suharti, N., Lucida, H., Husni, E., & Sedona, O. (2018). Karakterisasi dan studi aktivitas antioksidan dari ekstrak etanol secang (Caesalpinia sappan L.). JSFK (Jurnal Sains Farmasi & Klinis), 5(1), 23-27.
Garg, A., Aggarwal, D., Garg, S. & Singla, A. K. (2002). Spreading of Semisolid Formulations, An Update. Pharmaceutical Technology; 2002; 84-105.
Hasrawati, A., Hardianti, H., Qama, A., & Wais, M. (2020). Pengembangan Ekstrak Etanol Limbah Biji Pepaya (Carica papaya L.) Sebagai Serum Antijerawat. Jurnal Fitofarmaka Indonesia, 7(1), 1-8.
Hindun Siti, Rusdiana Taofik, Abdasah Marline, Hindriatiani Reti. 2017. “Potensi Limbah Kulit Jeruk Nipis ( Citrus Auronfolia ) Potency Of Lemon Peel ( Citrus Auronfolia ) Waste As Tirosinase Inhibitor.” 4:64–69.
Ismail I., 2013, Formulasi Kosmetik Produk Perawatan Kulit dan Rambut. Jurnal Ilmiah Universitas Alauddin, Makassar.
Jaafar, R. A. et al. (2009) ‘Proximate analysis of dragon fruit (Hylecereus polyhizus)’, American Journal of Applied Sciences, 6(7), pp. 1341–1346. doi: 10.3844/ajassp.2009.1341.1346.
Khasanah, I., Ulfah, M., & Sumantri, S. (2014). Uji Aktivitas Antioksidan Ekstrak Etanolik Kulit Buah Jeruk Nipis (Citrus aurantifolia) dengan Metode DPPH (1, 1-difenil-2-pikrilhidrazil). Jurnal Ilmu Farmasi dan Farmasi Klinik, 11(2), 9-17.
Kurniawati, A. Y., & Wijayanti, E. D., 2018, Karakteristik Sediaan Serum Wajah dengan Variasi Konsentrasi Sari Rimpang Temu Giring (Curcuma heyneana) Terfermentasi Lactobacillus bulgaricus. Akademi Farmasi Putra Indonesia Malang, 5(2): 1–11.
Loizzo, M. R., Tundis, R., Bonesi, M., Menichini, F., De Luca, D., Colica, C., & Menichini, F. 2012. Evaluation of Citrus aurantifolia Peel and Leaves Extracts for their Chemical Composition, Antioxidant and Anti-Cholinesterase Activities. Journal of the Science of Food and Agriculture, 92(15), 2960–2967.Loizzo, M. R., Tundis, R., Bonesi, M., Menichini, F., De Luca, D., Colica, C., & Menichini, F. 2012. Evaluation of Citrus aurantifolia Peel and Leaves Extracts for their Chemical Composition, Antioxidant and Anti-Cholinesterase Activities. Journal of the Science of Food and Agriculture, 92(15), 2960–2967.
Luthfiyana, N., Nurhikma, N., & Hidayat, T. (2019). Characteristics of peel off gel mask from seaweed (Eucheuma cottonii) porridge. Jurnal Pengolahan Hasil Perikanan Indonesia, 22(1), 119-127.
Mahargyani W. Identifikasi senyawa dan uji aktivitas antioksidan ekstrak etanol kulit buah naga merah (Hylocereus polyrhizus). Pinlitamas 1; 2018. p.614–22.
Manihuruk FM, Suryati T, Arief II. Effectiveness of the red dragon fruit (Hylocereus polyrhizus) peel extract as the colorant, antioxidant, and antimicrobial on beef sausage. Media Peternak. 2017;40(1):47–54.
Marjoni, M. R. (2018). Phenolics compounds, flavonoids, and antioxidant activity methanol extract of arum manis leaves (Mangifera indica L. Var. Arumanis). International Journal of Green Pharmacy (IJGP), 12(03).
Marjoni, Riza. 2016. “Dasar-Dasar Fitokimia Untuk Diploma III Farmasi.” Jakarta: Cv.Trans Info Media 39–43.
Mukhriani, M., Nurlina, N., & Baso, F. F. (2014). Uji aktivitas antimikroba dan identifikasi ekstrak buah sawo manila (Achras zapota L.) terhadap beberapa mikroba patogen dengan metode difusi agar. Jurnal farmasi UIN Alauddin Makassar, 2(2), 69-74
Nadia, S., Riyanti, R., & Nirmala, R. (2016). Uji Aktivitas Antioksidan Kombinasi Dari Kulit Buah Naga (Hylocereus costaricensis) dan Bunga rosela (Hibiscus sabdariffa) dengan Metode DPPH (1, 1 Diphenyl-2-picrylhidrazyl) Beserta Bentuk Tunggalnya. Jurnal Kesehatan Kusuma Husada.
Ning, D., Baki, A., Scherb, T., Song, J., Fantin, A., Liu, X., ... & Bouwmeester, H. J. (2019). Influence of A-site deficiency on structural evolution of Pr2-xNiO4+ δ with temperature. Solid state ionics, 342, 115056.
Noor, M. I., & Yufita, E. (2016). Identification Content of the Red Dragon Fruit Extract Skin Using Fourier Transform Infrared (FTIR) and Phytochemistry. Journal of Aceh Physics Society, 5(1), 14-16..
Nuari, Ris Ayu and Rachma Putri Maulida. 2020. “Uji Aktivitas Antioksidan Gel Ekstrak Kulit Jeruk Nipis ( Citrus Aurantifolia S ) Dengan Metode DPPH Dan METODE ABTS Antioxidants Activity Test of Lime Peel Extract Gel ( Citrus Aurantifolia S ) with DPPH and ABTS Methods.” 4(1):42–52.
Nurliyana, R., Syed Z.I., Mustapha S.K., Aisyah, M.R., dan Kamarul R.K. 2010. Antioxidant study of pulp and peel dragon fruits: a comparative study. Int. Food Res. J. 17: 365-375.
Okwu, D.E. 2008. Citrus Fruits: a Rich Source of Phytochemicals and Their Roles in Human Health, International Journal Chemical Science, 6 (2): 451-471.
Pansang, S., Maphanta, S., Tuntijarukorn, P., & Viyoch, J. (2010). Skin irritation test of a microemulsion containing essential oil isolated from Ocimum basilicum. Sci. Asia, 36, 355-358.
Pratiwi, D., Suswati, I., dan Abdullah, M. 2013. Efek Antibakteri Ekstrak Kulit Jeruk Nipis (Citrus aurantifolia)Terhadap Salmonella thypii Secara In Vitro. Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Vol. 9 No.2.
Rowe, Raymond; Sheskey, Paul J.; Owen; Sian C. 2006. Handbook of Pharmaceutical Excipient, Technical Services Leader, Midland: USA
Sayuti, K. & Yenrina, R. 2015. Antioksidan alami dan sintetik, Andalas University Press, Padang, Indonesia.
Septiani, R., Widyaningsih, S., & Iqomh, M. K. B. (2019). Tingkat perkembangan anak pra sekolah usia 3-5 tahun yang mengikuti dan tidak mengikuti Pendidikan Anak Usia Dini (PAUD). Jurnal Keperawatan Jiwa, 4(2), 114-125.
Septiyanti, M., Liana, L., Sutriningsih, S., Kumayanjati, B., & Meliana, Y. (2019, November). Formulation and evaluation of serum from red, brown and green algae extract for anti-aging base material. In AIP Conference Proceedings (Vol. 2175, No. 1). AIP Publishing.
Sholikhah, M. A., & Apriyanti, R. (2020). Formulasi Dan Karakterisasi Fisik Masker Gel Peeloff Ekstrak Lengkuas (Alpinia galanga,(L.) Sw). Jurnal Ilmu Farmasi dan Farmasi Klinik, 16(02), 99-104.
Simangunsong, W. S. (2019). Formulasi Sediaan Masker Gel Dari Ekstrak Mentimun (Cucumis Sativus L.) Kombinasi Ekstrak Buah Lemon (Citrus Limon L. Burm. Fil.) (Doctoral Dissertation, Institut Kesehatan Helvetia).
Suena, N.M.D.S., Meriyani, H., Antari, N.P.U. 2020. Uji Mutu Fisik dan Uji Hedonik Body Butter Maserat Beras Merah Jatiluwih. Jurnal Ilmiah Medicamento. 6(1): 59-65. Marjoni, R.M. (2016). Dasar-Dasar Fitokimia Untuk Diploma III Farmasi Cetakan I. Jakarta Timur : CV. Trans Info Media. Hal. 1; 15; 20-22.
Sutejo, A. M., Priyatmojo, A., & Wibowo, A. (2008). Identifikasi morfologi beberapa spesies jamur Fusarium. Jurnal Perlindungan Tanaman Indonesia, 14(1), 7-13.
Syarifah, S., Elfita, E., Widjajanti, H., Setiawan, A., & Kurniawati, A. R. (2021). Diversity of endophytic fungi from the root bark of Syzygium zeylanicum, and the antibacterial activity of fungal extracts, and secondary metabolite. Biodiversitas Journal of Biological Diversity, 22(10).
Thakre, A. D., 2017, Formulation and development of de pigment serum incorporating fruits extract. International Journal of Innovative Science and Research Technology, 2(12): 330–382.
Tundis, R., F., Menichini, M., Bonesi, F., Conforti, G., Statti, F., Menichini, M., R., Loizzo. 2013. Antioxidant and Hypoglycaemic activities and their relationship to phytochemicals in capsicum annuum cultivars during fruit development. LWT-Food Science and Technology. 53(1):370-377.
Vijayakumar R, Abd Gani SS, Zaidan UH, Halmi MIE, Karunakaran T, Hamdan MR. Exploring the potential use of Hylocereus polyrhizus peels as a source of cosmeceutical sunscreen agent for its antioxidant and photoprotective properties. Evidence-based Complementary and Alternative Medicine. 2020;2020.
Woo, K., Wong, F. F., dan Chua, H. C. 2011. Stability of the Spray-Dried Pigment of Red Dragon Fruit Hylocereus polyrhizus (Weber) Britton and Rose] as a Function of Organic Acid Additives and Storage Conditions. Philipp Agric Scientist Vol. 94 No. 3, 264-269.
Wu, L.C., H.W. Hsu., Y.C. Chen., C.C. Chiu., Y. I. L. dan A. H. (2006) ‘Antioxidant And Antiproliferative Activities of Red Pitaya’, Food Chemistry, Vol. 95, pp. 319–327.
Published
2024-05-05
Section
Articles
