FORMULASI DAN UJI EFEKTIVITAS SEDIAAN KRIM EKSTRAK DAUN KELOR (Moringaoleifera) TERHADAP PENYEMBUHAN LUKA BAKAR PADA TIKUS PUTIH JANTAN (Rattus novergicus)

Abstract

Burns are iinjuries ito ithe iskin ior iother iorganic itissue imainly icaused iby iheat ior idue ito iradiation, ifriction ior icontact iwith ichemicals. i iOne iof ithe iplants ithat ihave ithe ipotential ias ia iburn itreatment iis iMoringa ileaves. i iIn iMoringa i(Moringaoleifera) ileaves, iflavonoid ichemical icompounds ican iact idirectly ias iantibiotics iby iinterfering iwith ithe ifunction iof imicroorganisms isuch ias iburns. Objective to idetermine ithe imost ieffective iconcentration iof iMoringa i(Moringaoleifera) ileaf iethanol iextract ifor ihealing iburns iin imale iwhite irats. Methodirats ithat ihave ibeen ianesthetized iwith ilidocaine imuscularly. i Wounds iin rats iwere imade iby iattaching ia iheated i1 ix i1 icm istainless iplate. i iOn ithe ibacks iof irats iwhose ifur ihas ibeen ishaved iand iaffixed ito ithe iplate ifor i30 iseconds ito iform iblisters ior iburns, ithen ithe ipositive icontrol iconcentration igroup iis iapplied iwith ibioplacenton, ithe inegative icontrol iis ismeared iwith icream ibase, iand ithe itest igroup iis ismeared iwith iconcentrated iMoringa ileaf iextract icream i5%, i10% iand i.15%. i iThe ismearing iof iall itreatment igroups iwas icarried iout ievenly i3 itimes ievery iday, iobserving ichanges iin iburns ifor i14 idays. \

Results ithere iwas ia ireduction iin iburn ilength iat ieach iconcentration. i iThe ipositive icontrol ishowed ithe ifastest ireduction ievery iday ibecause iit icontained placenta extract and neomycin sulfate, in the negative control the wound healing was quite long from the wound diameter because it only used a cream base that did not contain nutritious substances. And at a concentration of 15% faster in the wound healing process. Conclusion:Moringa leaf ethanol extract at a concentration of 15% was the most effective in healing burns in male white rats compared to concentrations of 5% and 10%.