2026-04-14T21:04:50Z https://ejournal.delihusada.ac.id/index.php/JPFH/oai

oai:ojs2.ejournal.delihusada.ac.id:article/30 2021-12-15T17:07:36Z JPFH:FAR driver

FORMULATION OF OINTMENT OF ANTIBACTERY ETHANOL EXTRACT OF TORCH GINGER (Etlingera elatior) AGAINST BACTERIA STAPHYLOCOCCUS AUREUS Pulungan, Ainil Fithri Sitepu, Debi Dinha Octora Sinaga, Devi Mariana One of the causes of infection was bacteria, such as Staphylococcus aureus. Torch ginger has been widely used to treat dwaseases caused by bacteria. Torch ginger has been studied to have antibacterial activity against Staphylococcus aureus bacteria. The purpose of thwas study was to formulate an ointment preparation of ethanol extract of torch ginger and to see if the ointment preparations had antibacterial activity against Staphylococcus aureus bacteria. The research method used in thwas research was experimental True, covering the stages: making of ethanol extract of kecombrang flower with maceration method using 96% ethanol solvent, ointment formulation made with ointment base: vaseline, adeps lanae, and propylene glycol. Made in three concentrations of extracts namely: F I with 100 mg, F II with 200 mg, and F III with 300 mg. Furthermore, the evaluation of the preparation of evaluation of physical stability and homogeneity, and test of antibacterial activity against Staphylococcus aureus bacteria with diffusion method to use Kirby odor dwasc paper. The results showed that the ointment had good physical stability and homogeneity for 30 days of storage at room temperature. The antibacterial activity test of the ointment shows that the inhibitory diameter F I has an average of 16.45 mm, F II has an average of 18.60 mm and F III has an average of 21.12 mm. Based on the results obtained it can be concluded that the preparation of the ethanol extract of torch ginger has an inhibitory power to Staphylococcus aureus bacteria. In the next research was expected to pay attention to the growing area of ​​torch ginger  and to compare the antibacterial activity between petal flowers and flower seeds using Staphylococcus aureus bacteria. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2018-10-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/30 10.36656/jpfh.v1i1.30 Jurnal Penelitian Farmasi Dan Herbal; Vol 1 No 1 (2018): Jurnal Penelitian Farmasi & Herbal; 1-5 2654-7619 10.36656/jpfh.v1i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/30/1 10.36656/jpfh.v1i1.30.g1

oai:ojs2.ejournal.delihusada.ac.id:article/57 2021-12-15T17:07:36Z JPFH:FAR driver

COMPARISON OF ANTIBACTERIAL ACTIVITY TEST OF ETHANOL EXTRACT RED GALANGAL LEAF (ALPINIA PURPURATA K. SCHUM) AND TURMIN LEAF (CURCUMA DOMESTICA VAL.) TOWARD ESCHERICHIA COLI BACTERIA AND STAPHYLOCOCUS AUREUS BACTERIA Simanjuntak, Elisa Monika Barimbing, Nursia br Padila, Sindy Red Galangal (Alpinia purpurata K. Schum) and turmeric (Curcuma Domestica Val.) plant are icluded in the Zingeberaceae family. The utilization of parts of red galangal and turmeric plants such as rhizomes can be used as medicine. The objective of research is to determine the antibacterial activity of red galangal and turmeric leaves extracts. Examination of simplicia characteristics include : macroscopic, microscopic examinations, determination of water content, determination of ash content. Phytochemical screening includes examination of classes of alkaloids, flavonoids, glycosides, saponins, tannins and steroids/triterpenoids. The extraction was done by maceration using 96% ethanol as solvent. The antibacterial activity by agar diffusion method to using paper discs against Escherichia coli and Staphylococcus aureusbacteria. Simplex characterization for red galangal dan turmeric were showed water level of red galangal is 4,73% and turmeric is 6,83%. Ash content of red galangal is 3,64% and turmeric is 5,45%. The results of phytochemical screening of red galangal is alkaloids, flavonoids, glycosides, saponins, tannins and steroids/triterpenoids. Turmeric is alkaloids, flavonoids, glycosides, saponins, tannins. The results of antibacterial activity test showed that there were antibacterial differences of leaf extract of red galangal ant turmeric leaves in which turmeric leaves were more effective against Escherichia coli and Staphyloccus aureus than red galangal.   Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2018-10-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/57 10.36656/jpfh.v1i1.57 Jurnal Penelitian Farmasi Dan Herbal; Vol 1 No 1 (2018): Jurnal Penelitian Farmasi & Herbal; 6-10 2654-7619 10.36656/jpfh.v1i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/57/4 10.36656/jpfh.v1i1.57.g4 Copyright (c) 2018 Elisa Monika Simanjuntak, Nursia br Barimbing, Sindy Padila

oai:ojs2.ejournal.delihusada.ac.id:article/58 2021-12-15T17:07:36Z JPFH:FAR driver

PHENOL COEFFICIENT OF DISINFECTANT PRODUCTS DISTRIBUTED IN A SUPERMARKET OF LUBUK PAKAM shufyani, Fahma - Pratiwi, Asti Siringoringo, Wantrio Pardomuan Disinfectant products distributed in Lubuk Pakam vary in types from different manufacturers. The disinfectant ingredients are phenol and quartenary ammonium. The potency of disinfectant for killing microorganisms needs to be evaluated to assure the quality of the products. This study was carried out to determine the effectivity of disinfectant products based on phenol coefficient. Phenol coefficient testing of disinfectant products was microbiologically performed against Salmonella typhi. The disinfectant solutions were prepared by diluting the sample in sterile distilled water in ratio of 1:5, 1:10, 1:20, 1:30, 1:40, and 1:50. Phenol solution (5%, w/v) was used as disinfectant standard. The growth of bacteria was observed at the exposure time of 5, 10, and 15 minutes. The results indicated that the phenol coefficient of product A, B, C, D, E, F, and G were 2.38, 2.00, 3.00, 3.38, 2.38, 2.63, and 3.00, respectively. Statistical analysis using Kruskal-Wallis test showed that the quality of desinfectant products was significantly different (p < 0.05). This study revealed that product A, B, C, D, E, F and G distributed in many supermarket of Lubuk Pakam fulfilled the requirement of disinfectant activity. Product that contain HCl had the strongest activity than other disinfectant products. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2018-10-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/58 10.36656/jpfh.v1i1.58 Jurnal Penelitian Farmasi Dan Herbal; Vol 1 No 1 (2018): Jurnal Penelitian Farmasi & Herbal; 11-16 2654-7619 10.36656/jpfh.v1i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/58/5 10.36656/jpfh.v1i1.58.g5 Copyright (c) 2018 Fahma - shufyani, Asti Pratiwi, Wantrio Pardomuan Siringoringo

oai:ojs2.ejournal.delihusada.ac.id:article/59 2021-12-15T17:07:36Z JPFH:FAR driver

THE EFECT OF IMMUNOMODULATOR BY EXTRACT ETHANOL OF HERBA BINARA (ARTEMISIA VULGARIS L.) TOWARD THE RESPONSE OF DELAYED-TYPE HYPERSENSITIVITY IN RAT MALE Marbun, Romauli Anna Teresia Situmorang, Novidawati Wahyuni, Sri Immunomodulator is a compound that can increaase the imuno system. One of the plants that have immunomodulator’s activity is Herba Binara (Artemisia vulgaris L.). the purpose of this research was to test the effect of immunomodulator by extract of herba binara ethanol on rat male. The activity of immunomodulator was determined by using digital pletysmometer by measuring the differences between the last leg swelling’s volume and the first leg swelling’s volume. The treatment group were divided into 5 groups. Each group consistof 5 rats CMC-Na 0,5% (negative control), Imboost 32,5 mg/kgBW (positive control), dose of EEHB 50, 100, 200 mg/kgBW, and bacteria E.coli as antigen. The results slowed that distribution of EEHB dose 200 mg/kgBW can give the effect of immunostimulant by swelling enthancement compared by CMC-Na 0,5 %. EEHB 200 mg/kgBW that have activity comparable with Imboost 32,5 mg/kgBW. Thus, it is concluded that of herba binara extract has immunomodulator effects on delayed-type hypersensitivity response of rat male. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2018-10-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/59 10.36656/jpfh.v1i1.59 Jurnal Penelitian Farmasi Dan Herbal; Vol 1 No 1 (2018): Jurnal Penelitian Farmasi & Herbal; 17-21 2654-7619 10.36656/jpfh.v1i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/59/6 10.36656/jpfh.v1i1.59.g6 Copyright (c) 2018 Romauli Anna Teresia Marbun, Novidawati Situmorang, Sri Wahyuni

oai:ojs2.ejournal.delihusada.ac.id:article/60 2021-12-15T17:07:36Z JPFH:FAR driver

SOLID BATH SOAP DOSAGE FORMULATIONS OF THE ETHANOL EXTRACT OF FRESH FRUIT OF MORINDA (MORINDA CITRIFOLIA L.) Sihombing, Yanna Rotua Syarifudin, Aminah Berutu, Rinaldo  Morinda plants grow widely throughout the Pasipic and are one of the most significant sources of traditional medicine among the Pacific island community.  Morindas contain natural antioxidants for skin health and saponins in the manufacture of soap. Morindas also has potential as an antibacterial (Flavanoid). The purpose of this research is to formulate the ethanol extract of the fruit of morinda (Morinda citrifolia L.) fresh bath soap. Preparations to become solid. This research uses experimental methods. Morinda fruit is extracted by a process of maceration. Solid bath soap preparations inspection conducted this research is test the pH with a concentration of 2,5%, 3,5% and 4,5%. Ethanol extract of the fruit of morindas can be preparations soap formulations in bath with solid inspection results show pH, pH range between 8,5-10,1 show that the solid bath soaps are qualified solid bath soap. The result showed solid bath soap preparations from ethanol extract of the fruit of morinda (Morinda citrifolia L.) fresh with variations in defferent concentrations can be formulated in to a solid bath soap. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2018-10-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/60 10.36656/jpfh.v1i1.60 Jurnal Penelitian Farmasi Dan Herbal; Vol 1 No 1 (2018): Jurnal Penelitian Farmasi & Herbal; 22-24 2654-7619 10.36656/jpfh.v1i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/60/7 10.36656/jpfh.v1i1.60.g7 Copyright (c) 2018 Yanna Rotua Sihombing, Aminah Syarifudin, Rinaldo Berutu

oai:ojs2.ejournal.delihusada.ac.id:article/61 2021-12-15T17:08:49Z JPFH:FAR driver

DEPRESI INDUCED STEROID: STUDI KASUS Batubara, Saiful Back Ground: Depression is a natural disturbance of feeling that is characterized by feelings of sadness, loss of interest and easily tired. Steroids are drugs that can reduce swelling, pain and heat due to inflammation through reducing the immune response. Steroids are often used in cases of systemic Lupus Erythematosus in the long term. Therefore management of the disease must be done well because steroids can cause depression. Case Report:Women, 37 years old, depressed mood, disappointment in life, loss of enthusiasm, fatigue, decreased appetite and difficulty sleeping for 1 year. 4 years ago I took steroids for 2 years at a dose of 20mg / day, because rheumatoid arthritis was stopped by os, and for the past 1 year, steroid consumption was due to Systemic Lupus Erythematosus around 60 mg / day. . Before the os consumes steroids, the OS has never experienced depression.BP: 110/70 mmHg , HR 88x/menit, RR 20x/menit, Temp 37°C. Skor BDI 21. Laboratorium Hb 11,8 g/dl, Leukosit 7500/mm3, trombosit 201.000/mm3,,Kalium 2,8, KGDad 99 mg/dlSGOT 29 ,SGPT32, Ureum 15,78 mg/dl, Creatinin 0,65 mg/dl.  Tot Colesterol 198mg/dl,  LDL 128 mg/dl, HDL 35 mg/dl Fototoraks : Jantung dan Parudalambatas normal, FotoLumbosakral : SpondilosisLumbalis. The patient is diagnosed with depression. Given psychotherapy, sandepril 2 x 25 mg for 3 months. Patients show clinical improvement marked by reduced sadness and can understand the disease. Conclusion :Steroid-induced depression has been reported after psychotherapy and sandepril 2 x 25 mg of the patient's condition showed improvement. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2019-04-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/61 10.36656/jpfh.v1i2.61 Jurnal Penelitian Farmasi Dan Herbal; Vol 1 No 2 (2019): Jurnal Penelitian Farmasi & Herbal; 1-4 2654-7619 10.36656/jpfh.v1i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/61/8 10.36656/jpfh.v1i2.61.g8 Copyright (c) 2019 Saiful Batubara

oai:ojs2.ejournal.delihusada.ac.id:article/62 2021-12-15T17:08:49Z JPFH:FAR driver

IDENTIFIKASI KADAR GLUKOSA DAN SUKROSA PADA MADU HUTAN NST, ZUHAIRIAH BR GINTING, ERNALA ROMATUA, DYNA GRACE FAHDI, FIRDAUS Abstract Glucose and sucrose tests are performed as one of honey’s standard quality. Meanwhile the process of honey production by bees itself is a complex process, so there is a high probability of differences in the levels and composition of glucose and sucrose among the types of honey circulating in the community. The composition of glucose and sucrose of each honey can affect its efficacy mainly when it is used for treatment process. The aim of this research is to know  glucose and sucrose level in forest honey and compare it with honey’s standard quality according to Indonesian national standard (SNI 01-3545-2013). The samples were 3  forest honey from different village. Sample A is forest honey from Kubu Simbelang Village, Sample B from Bunuraya Village, and Sample C from Suka Village, Tigapanah District. The determination of glucose and sucrose levels was performed by Luff Schoorl method. The result of this study was glucose average level of each sample A, B and C  is 71,42%, 66,24%, and 71,21%. The sucrose average levels of sample A, B, and C is 3,09%, 4,51, and 3,04%.It can be stated thatall  forest honey used in this study has fulfilled  the requirements according to SNI 01-3545-2013 which set that glucose level of honey must be at least 65%while the sucrose level is maximum 5%. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2019-04-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/62 10.36656/jpfh.v1i2.62 Jurnal Penelitian Farmasi Dan Herbal; Vol 1 No 2 (2019): Jurnal Penelitian Farmasi & Herbal; 5-10 2654-7619 10.36656/jpfh.v1i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/62/18 10.36656/jpfh.v1i2.62.g18 Copyright (c) 2019 ZUHAIRIAH NST, ERNALA BR GINTING, DYNA GRACE ROMATUA, FIRDAUS FAHDI

oai:ojs2.ejournal.delihusada.ac.id:article/63 2021-12-15T17:08:49Z JPFH:FAR driver

UJI IMUNOMODULATOR DARI EKSTRAK ETANOL DAUN WARU (HIBISCUS TILIACEUS) DENGAN METODE HIPERSENSITIVITAS TIPE LAMBAT Sihombing, Yanna Rotua Octora, Debi Dinha Immunomodulator is a compound that can increaase the imuno system. One of the plants that have immunomodulator’s activity is Waru Leaf (Hibiscus tiliaceus). the purpose of this research was to test the effect of immunomodulator by extract of Waru Leaf ethanol on rat male. The activity of immunomodulator was determined by using digital pletysmometer by measuring the differences between the last leg swelling’s volume and the first leg swelling’s volume. The treatment group were divided into 5 groups. Each group consistof 5 rats CMC-Na 0,5% (negative control), Stimuno®  32,5 mg/kgBW (positive control), dose of EEDW 50, 100 and 200 mg/kgBW, and bacteria E.coli as antigen. The results slowed that distribution of EEDW dose 200 mg/kgBW can give the effect of immunostimulant by swelling enthancement compared by CMC-Na 0,5 %. EEDW 200 mg/kgBW that have activity comparable with Stimuno®  32,5 mg/kgBW. Thus, it is concluded that of Waru Leaf extract has immunomodulator effects on delayed-type hypersensitivity response of rat male. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2019-04-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/63 10.36656/jpfh.v1i2.63 Jurnal Penelitian Farmasi Dan Herbal; Vol 1 No 2 (2019): Jurnal Penelitian Farmasi & Herbal; 11-16 2654-7619 10.36656/jpfh.v1i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/63/19 10.36656/jpfh.v1i2.63.g19 Copyright (c) 2019 Yanna Rotua Sihombing, Debi Dinha Octora

oai:ojs2.ejournal.delihusada.ac.id:article/64 2021-12-15T17:08:49Z JPFH:FAR driver

ANTIBAKTERI SENYAWA FENOLIK DARI DAUN SAPUTANGAN (Maniltoa Grandiflora (A. Gray) Scheff) SINURAT, JHON PATAR SIREGAR, SAADAH The Phytochemical screening test to identify secondary metabolites of Saputangan leaves extract (Maniltoa grandiflora (A.Gray) Scheff) showed positive results on phenolic and terpenoid compounds. The reagent used for phenolic screening was 5% FeCl3 and reagent for screening terpenoid was 1% CeSO4 in 10% H2SO4. Antibacterial test was carried out by agar diffusion method on extracts of DMSO Saputangan leaves. Phenolic compound obtained from extract of Saputangan leaves were 36.96 gram where the result was obtained after maceration, partitioning and evaporation processes. Antibacterial of phenolic compound was observed based on inhibitory zone diameters of phenolic compounds formed using paper discs with a diameter of 6 mm. The diameters of the inhibition zone against Escherichia coli bacteria are 8.1; 8.5 and 9.7 mm larger than the diameter of the inhibition zone in Staphylococcus aureus bacteria at 7.3; 7.8 and 8.5 mm. Then it can be stated that DMSO extracts of phenolic compound with concentrations (0.25; 0.50 and 1.00 mg / ml) have antibacterial strength at the medium level where the average inhibition zone of S. aureus bacteria is 7.87 mm and the average inhibition zone in E. coli bacteria is 8.76 mm. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2019-04-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/64 10.36656/jpfh.v1i2.64 Jurnal Penelitian Farmasi Dan Herbal; Vol 1 No 2 (2019): Jurnal Penelitian Farmasi & Herbal; 17-21 2654-7619 10.36656/jpfh.v1i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/64/20 10.36656/jpfh.v1i2.64.g20 Copyright (c) 2019 JHON PATAR SINURAT, SAADAH SIREGAR

oai:ojs2.ejournal.delihusada.ac.id:article/66 2021-12-15T17:08:49Z JPFH:FAR driver

UJI IMUNOSTIMULATOR DARI KOMBINASI EKSTRAK ETANOL HERBA BINARA (ARTEMISIA VULGARIS LINN) DAN EKSTRAK ETANOL DAUN PUCUK MERAH (SYZYGIUM OLEANA) DENGAN METODE HIPERSENSITIVITAS TIPE LAMBAT PADA TIKUS Teresia Marbun, Romauli Anna Syarifuddin, Aminah Silalahi, Montysory Fista Ginting, Radika Bella One of the herbs used is herbal binara (Artemisia vulgaris L) which has been studied as a potential immunomodulator with high antioxidant activity. Previous research also stated that red shoots (Syzygium oleana) were studied as potential immunomodulators with high antioxidant activity. Several other species such as Syzygium samarangense have 16 flavonoida compounds which show pharmacological immunological activity. The purpose of this study was to determine the content of secondary metabolites of ethanol extract of herbal binara (Artemisia vulgaris L.) with red shoots (Syzygium oleana) and to determine the best dose of extract from the ethanol extract of herbal binara (Artemisia vulgaris L.) with red shoots (Syzygium oleana) can reduce the volume of swelling of mouse feet. Examination of the chemical content of secondary metabolites from the ethanol extract of herbal binara (Artemisia vulgaris L.) with red shoots (Syzygium oleana) is carried out by chemical screening and characterization of simplicia and extract. The method used is the slow type hypersensitivity method. In this test the independent variable is the secondary metabolite of ethanol extract of herb binara (Artemisia vulgaris L.) with red shoots (Syzygium oleana) with four concentrations (50, 100, 200 and 400 mg / kgBB). The positive control used by Stimuno dose is 32.5 mg / kgBB. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2019-04-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/66 10.36656/jpfh.v1i2.66 Jurnal Penelitian Farmasi Dan Herbal; Vol 1 No 2 (2019): Jurnal Penelitian Farmasi & Herbal; 22-26 2654-7619 10.36656/jpfh.v1i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/66/21 10.36656/jpfh.v1i2.66.g21 Copyright (c) 2019 Romauli Anna Teresia Marbun, Aminah Syarifuddin, Montysory Silalahi, Radika Bella Fista Ginting

oai:ojs2.ejournal.delihusada.ac.id:article/69 2021-12-15T17:08:49Z JPFH:FAR driver

DETERMINATION OF MINERAL Ca CONTENT IN SEVERAL KINDS OF FRESH FOOD AND PROCESSED PRODUCTS AS SWEETMEAT Hasibuan, Ahmad Syukur Shufyani, Fahma Rinaldo, Rinaldo The basic thing that differentiate both is how to make it, lasting power, and design products. This study aims to determine the level of calcium in the sample of fresh guava, ginger, and nutmeg, and to investigate the mineral calcium levels in samples of fresh and processed products as wet sweetmeat and dry sweetmeat. Each sample must first be destructed by dry destruction, then the mineral assay performed with quantitative assay atomic absorption spectrophotometry (AAS) using a gas burner nitrous oxide-acetylene at a wavelength of 422.7 nm. The advantage of this method is to have a high sensitivity (limit of detection of less than 1 ppm), and the implementation is relatively simple. Calcium levels in samples of fresh guava, ginger and nutmeg in a row each each sample as follows (7.7105 ± 0.1224) mg / 100 g, (14.5232 ± 0.117) mg / 100 g and (38, 8834 ± 0.6996) mg / 100 g. In the wet sweetmeat guava, ginger and nutmeg for (13.7787 ± 0.4123) mg / 100 g, (22.8345 ± 0.8247) mg / 100 g and (0.2284 ± 0.3759) mg / 100 g. While on dry sweetmeat guava, ginger and nutmeg for (160.9401 ± 0.4223) mg / 100 g, (176.0465 ± 1.0458) mg / 100 g and (120.4426 ± 0.7932) mg / 100 g. Levels of calcium contained in a sample of fresh guava, ginger and nutmeg and sweetmeat processed as wet and dry sweetmeat has different levels Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2019-04-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/69 10.36656/jpfh.v1i2.69 Jurnal Penelitian Farmasi Dan Herbal; Vol 1 No 2 (2019): Jurnal Penelitian Farmasi & Herbal; 27-32 2654-7619 10.36656/jpfh.v1i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/69/22 10.36656/jpfh.v1i2.69.g22 Copyright (c) 2019 Ahmad Syukur Hasibuan, Fahma Shufyani, Rinaldo Rinaldo

oai:ojs2.ejournal.delihusada.ac.id:article/73 2021-12-15T17:10:20Z JPFH:FAR driver

PENGARUH EKSTRAK KULIT BUAH MANGGIS (Garcinia Mangostana Linn) TERHADAP PERISTALTIK ILEUM TERPISAH MARMOT JANTAN SEBAGAI ANTI DIARE Anshari, Zaim Novalinda Ginting, Chrismis Chiuman, Linda Mardiati Lubis, Yuliani Objective: to determine the effect of mangosteen peel extract (Garcinia mangostana Linn) on ileal peristalsis separate male guinea pigs as diarrhea. Results: t-independent test, the difference: Contraction of ileum Acethlcholin with Atropine + Acethylcholin is 6.333 compared to Acethylcholin with extract + Acethylcholin is 8,500 with ANOVA test P value meaning the difference between the two contractions of the ileum is significant. The t-independent test results are the difference: Contraction of ileum Histamine with Diphenhidramine + Histamine is 8.333 compared to Histamine with extract + Histamine is 10.833 with ANOVA test P value meaning the difference between the two contractions of the ileum is significant. The results of the t-independent test are the difference: Contraction of the Barrium ileum with Papaverine + Barrium is 2,500 compared to the contraction of Barrium ileum with extract + Barrium is 2,500 with ANOVA test P value meaning that there is no difference between the two contractions of the ileum. From the three experimental groups, it was concluded that the extract worked similar to Papaverine. Cecilia's study, fruit skin extract can be used as diarrhea in Diare Effect of Mangosteen Ethanol Extract of Oleum ricini-induced Webster Swiss Mice. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2019-10-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/73 10.36656/jpfh.v2i1.73 Jurnal Penelitian Farmasi Dan Herbal; Vol 2 No 1 (2019): Jurnal Penelitian Farmasi & Herbal; 9-18 2654-7619 10.36656/jpfh.v2i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/73/24 10.36656/jpfh.v2i1.73.g24 Copyright (c) 2019 Zaim Anshari, Chrismis Novalinda Ginting, Linda Chiuman, Yuliani Mardiati Lubis

oai:ojs2.ejournal.delihusada.ac.id:article/77 2021-12-15T17:10:20Z JPFH:FAR driver

UJI AKTIVITAS ANTIBAKTERI DARI EKSTRAK ETANOL DAUN PERIA LAUT (Colubrina Asiatica L.) TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS DAN ESCHERICHIA COLI Fahdi, Firdaus Harwitavia, Harwitavia Sari, Herviani The discovery of new antibiotic drugs is getting more and more reactive. The plant of the peria laut leaf is one of the drugs that is often used as a traditional medicine and contains bioactive compounds of polyphenols, flavonoids, and saponins, which can inhibit antibacterial growth. Purpose of this study was to determine the antibacterial activity of ethanol extract of peria laut leaves (Colubrina asiatica L.) against Staphylococcus aureus and Escherichia coli bacteria. Method the experimental, of the sample used was concentrated marine peria laut leaf extract of 25mg/ml, 50mg/ml, 75mg/ml, 100mg/ml, 200mg/ml, 300mg/ml, 400mg/ml, and 500mg/ml, positive control of amoxicillin tablet 500 mg, negative control of dimethylsulfoxide with the method of disc diffusion testing using media Nutrient Agar. Results the showed thet the peria laut leaf extract positively contained bioactive alkaloid compounds, flavonoids, saponins, steroids, and tannins, and had inhibitory effects on Staphylococcus aureus and Escgerichia coli bacteria with various concentrations which had been tested on the average area of the highest inhibition zone of 18,6 mm in Staphylococcus aureus bacteria, and 10,2 mm in Escherichia coli bacteria. Conclusion peria laut leaf extract (Colubrina asiatica L.) has antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria in the most inhibitory zone at a concentration of 500mg/ml with a diameter of 18,6 in Staphylococcus aureus bacteria and 10,2 in Escherichia coli. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2019-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/77 10.36656/jpfh.v2i1.77 Jurnal Penelitian Farmasi Dan Herbal; Vol 2 No 1 (2019): Jurnal Penelitian Farmasi & Herbal; 19-23 2654-7619 10.36656/jpfh.v2i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/77/25 10.36656/jpfh.v2i1.77.g25 Copyright (c) 2019 Firdaus Fahdi, Harwitavia Harwitavia, Herviani Sari

oai:ojs2.ejournal.delihusada.ac.id:article/79 2021-12-15T17:10:20Z JPFH:FAR driver

UJI EFEKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK DAUN MENIRAN (Phyllanthus niruri L.) Dan KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) PADA TIKUS JANTAN PUTIH Sari, Herviani Kaban, Vera Estefania Situmorang, Friska Raulina Fahdi, Firdaus Purpose: To determine the effect of decreasing blood glucose levels in white rats using a combination of meniran and rosella compared to glibenclamide. Method: This research was carried out experimentally. Simplicia of meniran leaves and rosella macerated using 80% ethanol. The research used 21 rats that were induced by alloxan and divided into 7 groups and all compared using glibenclamide.Group 1 (negative control) CMC Na 1%, group 2 (positive control) glibenclamide dose 0.45 mg/kgMB, group 3 single roselle extract dose 130 mg/kgMB, group 4 single meniran leaf extract dose 200 mg/kgMB, group 5 combination of meniran leaf extract dose of 100 mg/kgMB and rosella extract dose of 65 mg/kgMB, group 6 combination of meniran leaf extract dose of 200 mg/kgMB and rosella extract dose of 130 mg/kgMB, and group 7 meniran leaf extract combination dose 400 mg/kgMB and rosella extract dose 195 mg/kgMB. Result: The results showed that rats had hyperglycemia after being induced by alloxan.Data were analyzed using one way ANOVA method followed by LSD and tukeys' B post hoct test. Having a difference in the decrease in blood glucose levels between the positive control group and the five doses of meniran extract and rosella gave a significant effect compared to the negative control group did not have a significant effect in reducing blood glucose levels. Conclusion: Single meniran extract and high-dose combination extract are more effective than glibenclamide. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2019-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/79 10.36656/jpfh.v2i1.79 Jurnal Penelitian Farmasi Dan Herbal; Vol 2 No 1 (2019): Jurnal Penelitian Farmasi & Herbal; 24-28 2654-7619 10.36656/jpfh.v2i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/79/26 10.36656/jpfh.v2i1.79.g26 Copyright (c) 2019 Herviani Sari, Vera Estefania Kaban, Friska Raulina Situmorang, Firdaus Fahdi

oai:ojs2.ejournal.delihusada.ac.id:article/81 2021-12-15T17:10:20Z JPFH:FAR driver

EFEKTIFITAS EPHEDRINE 20 μg/KgBB DIBANDINGKAN DENGAN LIDOKAIN 30 mg TERHADAP NYERI DAN RESPON HEMODINAMIK AKIBAT PENYUNTIKAN PROPOFOL PADA ANESTESIA UMUM DENGAN INTUBASI ENDOTRAKEA Firmanda, Dody Purpose: To determine the effectiveness of pain reduction and hemodynamic response using a 30 mg lidocaine and 20 μg/kg of BB in the thirty seconds before propofol induction in general anesthesia with endotracheal intubation. Methods: This study has a double-blind clinical test design. A total of 140 ASA-1 and ASA-2 patients who would undergo surgery with general anesthesia techniques used propofol induction and were taken by Endotraskea to obtain one of the two groups. Thirty seconds before propofol induction, the group I is by adding lidocaine 30 mg, while the group II is by adding the ephedrine 20μg/KgMW thirty seconds before propofol induction. Assess the value of VAS at the time of injection of the first three cc propofol with an injection speed of 15-18 seconds. Systolic, diastolic blood pressure, MAP, and heart rate are recorded before premedication (baseline), after premedication, after administration of ephedrine, after induction of propofol and the 1st minute, 3.5 after intubation. Statistical tests conducted with Chi-Square, Mann-Whitney, and Independent T-Test tests. Result: The comparison of the pain incidence rate between the two groups is the same as the value of VAS 0-3 in both groups. Indicate a meaningful difference in the ephedrine group 20 μg/KgMW obtained a median value of visual analog scale 0, 64.3% while VAS 1-3 as much as 35.7% in group Lidocaine 30 mg obtained by the median value of visual analog scale 0, 47.1% While at VAS 1-3 as much as 52.9%. The average arterial pressure of the ephedrine group is 30 seconds after the injection of propofol, 83 (73-91) mmHg, which is significantly higher when compared with the average arterial pressure of the group Lidocaine 30 mg, 74 (68-85) mmHg. Arterial pressure at 1, 3, and 5 min after intubation in the ephedrine group consistently demonstrated a significantly higher value than the arterial pressure of the lidocaine group. Conclusion: Ephedrine 20 μg/KgMW and 30 mg lidocaine are equally effective in terms of pain reduction due to propofol induction. Ephedrine 20 μg/KgMW provides a lesser effect of hemodynamic changes in the injection of general anesthesia with endotracheal intubation. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2019-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/81 10.36656/jpfh.v2i1.81 Jurnal Penelitian Farmasi Dan Herbal; Vol 2 No 1 (2019): Jurnal Penelitian Farmasi & Herbal; 29-37 2654-7619 10.36656/jpfh.v2i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/81/27 10.36656/jpfh.v2i1.81.g27 Copyright (c) 2019 Dody Firmanda

oai:ojs2.ejournal.delihusada.ac.id:article/83 2021-12-15T17:10:20Z JPFH:FAR driver

PENGARUH MEDIA AUDIO DAN VIDEO TERHADAP MAHASISWA PROGRAM STUDI FARMASI DALAM KEMAMPUAN BERBICARA DI INSTITUT KESEHATAN DELI HUSADA DELI TUA Gurusinga, Mona Fitri This study aims to find out: whether the use of video is more effective than using audio inimproving students' pharmacists 'speaking skills. Find out whether the use of video is moreeffective than general media use in improving students' speaking skills. Whether audio usage moreeffective rather than using conventional media in improving students 'speaking skills. Find outwhich media is the most effective among the use of Video, Audio, and conventional media onimproving students' speaking skills. This research is an experimental study using Quasi PretestPost-test Control Group design. The research sample was students pharmacist class 1A, 1B, and1C taken by a simple cluster random sampling technique. This research shows that video usage isthe most effective medium among all of them, and the use of video is more effective than usingaudio in improving students ' speaking skills. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2019-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/83 10.36656/jpfh.v2i1.83 Jurnal Penelitian Farmasi Dan Herbal; Vol 2 No 1 (2019): Jurnal Penelitian Farmasi & Herbal; 38-43 2654-7619 10.36656/jpfh.v2i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/83/28 10.36656/jpfh.v2i1.83.g28 Copyright (c) 2019 Mona Fitri Gurusinga

oai:ojs2.ejournal.delihusada.ac.id:article/124 2021-12-15T17:10:20Z JPFH:FAR driver

FORMULASI DAN EVALUAI STABILITAS FISIK PATCH TRANSDERMAL ALKALOID NIKOTIN DAUN TEMBAKAU (Nicotiana tobacum Linn) DENGAN VARIASI POLIMER DAN ASAM OLEAT Nurmesa, Adi Nurhabibah, Nurhabibah Najihudin, Aji Research on the tobacco leaves  nicotine alkaloid (Nicotiana tobacum L) transdermal patch formulation has been carried out as a cigarette dependence therapy with variations in polymers and oleic acid as a penetration enhancer. The purpose of this study is to formulate a stable transdermal patch of nicotine alkaloid tobacco leaf and to see the effect of adding cellulose, PVP and oleic acid to the release of nicotine in vitro. Transdermal patch formulation consists of nicotine alkaloid tobacco leaf, PVP, ethyl cellulose, PVP, PEG 400, propylenglycol and oleic acid. In this study, 3 formulas were made with concentration variants of PVP: EC namely F1 = 1: 1, F2 = 1: 2, and F3 = 1: 3, where the variations in penetration enhancements in the form of oleic acid were F1: 0.10, F2: 0.15, and F3: 0.20. Evaluation of transdermal patch preparations includes organoleptic, matrix weight test, matrix thickness test, drying shrinkage percentage, moisture uptake, matrix fold resistance test, skin irritation test, patch matrix surface pH test, elongation percentage, frezee and thaw test, nicotine content test, and nicotine release (diffusion cell) test, based on physical stability test of all relatively stable transdermal patch formulas and kinetics of transdermal patch release kinetics following first order and the results of statistical analysis using Variant Analysis (ANOVA) showed differences in F1, F2 and F3, and based on the Korsmayer Peppas test following the non-fick law Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2019-10-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/124 10.36656/jpfh.v2i1.124 Jurnal Penelitian Farmasi Dan Herbal; Vol 2 No 1 (2019): Jurnal Penelitian Farmasi & Herbal; 1-8 2654-7619 10.36656/jpfh.v2i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/124/23 10.36656/jpfh.v2i1.124.g23 Copyright (c) 2019 Adi Nurmesa, Nurhabibah Nurhabibah, Aji Najihudin

oai:ojs2.ejournal.delihusada.ac.id:article/180 2021-12-15T17:10:20Z JPFH:FAR driver

ANALISIS DESKRIPTIF EFEK SAMPING PENGGUNAAN OBAT ANTI TUBERCULOSIS PADA PASIEN TBC DI RSUD Dr. PIRNGADI MEDAN Dasopang, Eva Sartika Hasanah, Fenni Nisak, Chairul The bacteria Mycobacterium tuberculosis causes tuberculosis. That bacteria is a very strong bacterium, so it should used some antibiotics to kill the bacteria. Tuberculosis (TB) treatment has two stages of intensive and advanced stages. To improve the compliance of TB, patients generally use anti-tuberculosis drugs (OAT) a fixed-dose combination. In the intensive stage, there are at least four antibiotics in the OAT combines fixed-dose. The use of polypharmacy drugs leads to the onset of unwanted side effects and is one of the causes of tuberculosis patients to stop treatment. The purpose of this research is analyzing the side effects that occur during the treatment of anti-tuberculosis. Sampling techniques performed in a prospective observation of tuberculosis patients who consume OAT for two months with analysis using statistics. The results of the study are the most frequent adverse effects on OAT are itching, headache and nausea with a percentage of each 72%, joint pain 45%, abdominal pain 36.4%, less appetite and rash respectively 27,3% and reddish colour in the urine 18.2 %. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2019-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/180 10.36656/jpfh.v2i1.180 Jurnal Penelitian Farmasi Dan Herbal; Vol 2 No 1 (2019): Jurnal Penelitian Farmasi & Herbal; 44-49 2654-7619 10.36656/jpfh.v2i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/180/120 10.36656/jpfh.v2i1.180.g120 Copyright (c) 2019 Eva Sartika Dasopang, Fenni Hasanah, Chairul Nisak

oai:ojs2.ejournal.delihusada.ac.id:article/206 2021-12-15T17:11:33Z JPFH:FAR driver

UJI EFEKTIVITAS ANTIKOLESTEROL KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalina Del.) DENGAN EKSTRAK ETANOL DAUN KELAPA SAWIT (Elaeis guineensis Jacq.) PADA TIKUS HIPERKOLESTEROL Sari, Herviani Nurmaulia, Nurmaulia Wahyudi, Wahyudi Fahdi, Firdaus African leaves (Gymnanthemum amygdalina Del.) and palm leaves (Elaeis guineensis Jacq.) which is contain flavonoid, saponin, alkaloid, and tannin can be used to decrease cholesterol levels and reduced the risk of cardiovascular disease. This study aims to determine the effect of EEDA dan EEDKS combination on blood cholesterol levels in hypercholesterolemic mice. Sample in this study was African leaves and palm leaves which were taken purposively without comparing samples from other regions, then extracted by maceration using ethanol 96%. The results of data analysis from the three EEDA and EEDKS groups effected cholesterol reduction due to the sig value <0.05. Based on ANOVA one way analysis of the five most effective treatments is simvastatin then dose  400-600mg/kgBB, dose 200-300mg/kgBB, dose 100-150mg/kgBB and CMC Na 1%. The combination of EEDA and EEDKS has an antihypercholesterol effect, the combination of EEDA and EEDKS has an antihypercholesterol effect that is comparable to the positive control, and the finding from this study that the most effective dosage of EEDA and EEDKS as antihypercholesterol is at dosage 400-600 mg/kgBB. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/206 10.36656/jpfh.v2i2.206 Jurnal Penelitian Farmasi Dan Herbal; Vol 2 No 2 (2020): Jurnal Penelitian Farmasi & Herbal; 1-7 2654-7619 10.36656/jpfh.v2i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/206/176 10.36656/jpfh.v2i2.206.g176 Copyright (c) 2020 Herviani Sari, Nurmaulia Nurmaulia, Wahyudi Wahyudi, Firdaus Fahdi

oai:ojs2.ejournal.delihusada.ac.id:article/207 2021-12-15T17:11:33Z JPFH:FAR driver

EFEKTIVITAS PENYEMBUHAN LUKA SAYAT MENGGUNAKAN SALEP EKSTRAK ETANOL DAUN SENGGANI (Melastoma malabathricum L.) PADA KELINCI Kaban, Vera Estefania Aritonang, Jessi Octavia Hasibuan, Yulia Citra Meliala, Dian Ika Perbina Senggani plants also have a reddish purple flower, ripe fruit will break the color purple and reddish brown beans. However, the utilization of senggani leaves is still not getting attention, therefore, to increase the economic value and utilization of this plant, senggani leaf can be formulated in the extract ointment of senggani leaf ethanol to healing the cut on the rabbit so it is expected to give healing effect on the rabbit wound.The purpose of this research is to know the concentration of ethanol extract of senggani leaf in the formulation of the ointment which is most effective in healing the rabbit wound in rabbit and to know the ointment ratio of ethanol extract of senggani leaves with betadine ointment .The samples in this study were extract from senggani leaf extracted by maceration using 80% ethanol solvent and formulated in ointment preparation using ingredients of adeps lanae and vaseline album. All data were tested statistically using ANOVA ONE WAY.Preparation of ointment extract of ethanol senggani leaf can accelerate the healing process of the wound and the most effective is the syrup leaf extract of 50% with an average healing for 11 days while betadine ointment does not experience healing until day 14.Indicating differences between treatment groups were more effective in healing of cuts on rabbits and 50% extracts of ethanol extracts of senggani leaf were more effective than with betadine ointment. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/207 10.36656/jpfh.v2i2.207 Jurnal Penelitian Farmasi Dan Herbal; Vol 2 No 2 (2020): Jurnal Penelitian Farmasi & Herbal; 8-14 2654-7619 10.36656/jpfh.v2i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/207/179 10.36656/jpfh.v2i2.207.g179 Copyright (c) 2020 Vera Estefania Kaban, Jessi Octavia Aritonang, Yulia Citra Hasibuan, Dian Ika Perbina Meliala

oai:ojs2.ejournal.delihusada.ac.id:article/208 2021-12-15T17:11:33Z JPFH:FAR driver

UJI EFEK ANTIDIARE EKSTRAK RIMPANG KUNYIT (Curcuma domestica val.) PADA MENCIT JANTAN Meliala, Linta Sari, Winda Tarigan, Palas Objectives : The purpose of this study to determine the effect and dose of effective use of rhizome extract of turmeric as antidiarrhea in male mice induced castor oil and the use of rhizome extract of turmeric equivalent to Loperamid HCl. Method : This research method is carried out experimentally with the research stages of sample preparation,  sample  characterization,  simplicia screening,  preparation  of  extracts, preparation  of  animal  experiments  and  testing  of  antidiarrheal  effects  in  experimental animals. Results : The results showed that the results of phytochemical screening of simplicia powder and turmeric rhizome extract contained flavonoids and tannins. SPSS statistical test results (statistical package for the social science) continued with defference test of Duncan average, the duration of the occurrence of diarrhea showed that the control group of Loperamid HCl dose 1 mg/kg bw gave significant effect on turmeric rhizome extract at doses of 40 mg/ kg bw and doses 80 mg/kg bw. The shorter the time of diarrhea, the stronger the antidiarrheal effect. Conclusion :  Turmeric rhizome extract dose 20 mg/kgbw showed that dose 20 mg/kgbw has antidiarrhea effect more than lower than Loperamid HCl dose 1 mg/kg bw. Turmeric rhizome extract dose 40 mg/kg bb has same effect with Loperamid HCl dose 1 mg/kgbb. And turmeric rhizome extract dose 80 mg/kgbb has effect more potencial that Loperamid HCl dose 1mg/kg bw. There is a relationship between the size of the dose with the antidiarrheal effect that occurs. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/208 10.36656/jpfh.v2i2.208 Jurnal Penelitian Farmasi Dan Herbal; Vol 2 No 2 (2020): Jurnal Penelitian Farmasi & Herbal; 15-21 2654-7619 10.36656/jpfh.v2i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/208/178 10.36656/jpfh.v2i2.208.g178 Copyright (c) 2020 Linta Meliala, Winda Sari, Palas Tarigan

oai:ojs2.ejournal.delihusada.ac.id:article/219 2021-12-15T17:11:33Z JPFH:FAR driver

PENETAPAN KADAR VITAMIN C PADA BEBERAPA JENIS CABE (CAPSICUM ANNUM L.) DAN PAPRIKA (CAPSICUM ANNUM L. VAR. GROSUM) DENGAN METODE TITRASI IODIMETRI Sembiring, Bunga Mari Siregar, Anggi Pramono Ascorbic acid is one of the nutrients that acts as an antioxidant to effectively overcome free radicals that can damage cells or tissues, including protecting the lens from oxidative damage caused by radiation. Ascorbic acid is abundant in fruits and vegetables, one of which is chili and pappers.The purpose of this study was to determine the content of the content and differences in levels of ascorbic acid content in several types of chillies and peppers. The method used in this study is the Iodimetry method, because ascorbic acid is a reducing agent which is strong enough, easily oxidized and iodine is easily reduced. This is one of the requirements of the compound can be done by the Iodimetry method. This research included descriptive research, with samples of red chili, cayenne pepper, curly green chili, red peppers, yellow peppers and green peppers obtained in the market of the old deli and its surroundings. This research begins with making samples, then performs qualitative tests, making standard solutions and determining ascorbic acid levels. During the titration process replication is done 6 times to compare the results of each titration. The results showed levels of ascorbic acid Red Chilli = 0.1856%, Cayenne pepper = 0.0739%, Curly green Chili = 0.0882%, Red peppers = 0.1945%, Yellow paprika = 0.1886%, and Green peppers = 0.1631%. Conclusions showed that the highest ascorbic acid levels were found in red pappers samples which were 0.1945% and the lowest ascorbic acid levels were in the cayenne sample which was 0.0739%. Suggestions for future researchers should be continued with other parameters and samples. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/219 10.36656/jpfh.v2i2.219 Jurnal Penelitian Farmasi Dan Herbal; Vol 2 No 2 (2020): Jurnal Penelitian Farmasi & Herbal; 22-30 2654-7619 10.36656/jpfh.v2i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/219/180 10.36656/jpfh.v2i2.219.g180 Copyright (c) 2020 Bunga Mari Sembiring, Anggi Pramono Siregar

oai:ojs2.ejournal.delihusada.ac.id:article/224 2021-12-15T17:11:33Z JPFH:FAR driver

IDENTIFIKASI CEMARAN BAKTERI (Escherichia coli) TERHADAP IKAN KEMBUNG DAN IKAN DENCIS YANG DIJUAL DI PASAR TRADISIONAL DELI TUA Fahdi, Firdaus Pratiwi, Dwi Sari, Helviani Introduction : Fish is a food that is easily damaged by enzymes or microorganism’s biological decay, thus requiring special handling. The process of spoilage of fish can be caused mainly by the activity of enzymes found in the body. This study aims to find out whether there are contaminants of Escherichia coli on mackerel (Rastrelliger sp) and dencis fish (Decapterus russelli) which are sold at the Deli Tua traditional market. Method : This type of research is true experimental with a Post Test Only Control Group Design. Sample was collected from the traditional market in Deli Tua with purposive sampling. Result :  from the observation of the number of bacterial colonies on the PCA media with mackerel and dencis fish samples in accordance with SNI because it exceeds 5,0X105 CFU/g. Conclusion : From the results of the study note that there is the contamination of Escherichia coli  bacteria in mackerel (Rastrelliger sp) and Dencis fish (Decapterus russelli) which are sold in the Deli Tua traditional market. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/224 10.36656/jpfh.v2i2.224 Jurnal Penelitian Farmasi Dan Herbal; Vol 2 No 2 (2020): Jurnal Penelitian Farmasi & Herbal; 31-37 2654-7619 10.36656/jpfh.v2i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/224/181 10.36656/jpfh.v2i2.224.g181 Copyright (c) 2020 Firdaus Fahdi, Dwi Pratiwi, Helviani Sari

oai:ojs2.ejournal.delihusada.ac.id:article/236 2021-12-15T17:11:33Z JPFH:FAR driver

UJI AKTIVITAS INFLAMASI EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) TERHADAP TIKUS PUTIH JANTAN (Galur wistar) Simorangkir, Delisma Hutagalung, Jenti Tarigan, Palas Background: Inflammation is a protective response of the body from the injury of the cell. Edema is one of the inflammation symptoms. Drumstick (Moringa oleifera L.) contains flavonoid a major of a bioactive constituent. Flavonoids inhibit COX-2 in inflammatory in mice. Objective: This study aims to investigate and to determine the anti-inflammatory activity and its effective dose extract. Method: Experimental. The extract was prepared by maceration method using ethanol 80%. An anti-inflammatory activity test was performed in five different groups. Each group consisted of 5 rats. The 1st group (negative control) was given 0,5% CMC-Na suspension, the 2nd group (positive control) was given diclofenac sodium 2,25 mg/kg BW, the 3rd, 4th, and 5th groups were successively given the drumstick leaf extract as much as 100, 150, and 200 mg/kg BW. Each rat was then induced by 1% carrageenan and tested using the subplantar method. The inflamed paw volume was measured using plestymometer. The measurements were done for 3 hours long with intervals of 30 minutes. The data were statistically analyzed using ANOVA (Analysis of Variance). Results: The results showed that the negative control had a significant difference with the other treatment groups which did not show any anti-inflammatory effect. Conclusion: Extract of a drumstick at a dose of 200 mg/kg BW has a better anti-inflammatory effect than ethanolic of a drumstick at dose of 100, 150 mg/kg BW, but still under sodium diclofenac.     Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/236 10.36656/jpfh.v2i2.236 Jurnal Penelitian Farmasi Dan Herbal; Vol 2 No 2 (2020): Jurnal Penelitian Farmasi & Herbal; 38-42 2654-7619 10.36656/jpfh.v2i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/236/182 10.36656/jpfh.v2i2.236.g182 Copyright (c) 2020 Delisma Simorangkir, Jenti Hutagalung, Palas Tarigan

oai:ojs2.ejournal.delihusada.ac.id:article/258 2021-12-15T17:11:33Z JPFH:FAR driver

FORMULASI KRIM EKSTRAK DAUN NANGKA (Artocarpus heterophyllus L.) TERHADAP BAKTERI Propionibacterium acne Shufyani, Fahma Yudistira, Sara Mabrur, Muhammad Sari, Armaliza Permata Jackfruit leaf is (Artocarpus heterophyllus L) is one of the natural ingredients that can be used as a therapeutic treatment of acne. To facilitate its use the extract is made in the form of a cream. This study aims to determine the antibacterial activity of anti-acne cream jackfruit leaf extract against propionibacterium acne with concentrations of 30%, 50%, 70%, and 90%. Compounds that act as antibacterials on jackfruit leaves include flavonoids, tannins, saponins. This research method is an ANOVA one way method. The extraction method used is the maceration method. The tests include physical stability test and anti-acne activity test. Physical preparation stability test is carried out every 6 days for 3 weeks. While the anti-acne activity observation test was carried out on Propionibacterium acne bacteria. Based on the observation of organoleptic preparations of formulations 1 and 2 there was no change, while 3,4,5 there was a change. Anti- acne activity test showed that formulations 1 and 2 were more effective than formulations 3, 4, 5 with an average inhibition zone of 9.5 mm. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/258 10.36656/jpfh.v2i2.258 Jurnal Penelitian Farmasi Dan Herbal; Vol 2 No 2 (2020): Jurnal Penelitian Farmasi & Herbal; 43-49 2654-7619 10.36656/jpfh.v2i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/258/183 10.36656/jpfh.v2i2.258.g183 Copyright (c) 2020 Fahma Shufyani, Sara Yudistira, Muhammad Mabrur, Armaliza Permata Sari

oai:ojs2.ejournal.delihusada.ac.id:article/278 2021-12-15T17:11:33Z JPFH:FAR driver

FORMULASI DAN UJI AKTIVITAS KRIM TABIR SURYA EKSTRAK BIJI KAKAO (Theobroma cacao L.) DENGAN KOMBINASI AVOBENZONE DAN OCTYL METHOXYCINNAMATE Meliala, Dian Ika Perbina Wahyudi, Wahyudi Nelva, Nelva Sunscreen is a cosmetic ingredient that can physically resist UV A and UV B rays. UV A radiation can cause brown color on the skin and UV B rays can cause skin burn. Although the skin has protection against sunlight, it is still necessary to use sunscreen on the skin. Substances Antioxidants are substances that at small concentrations can significantly inhibit oxidation on the substrate caused by free radicals. One plant that contains natural antioxidants is cocoa beans.To determine the value of Sun Protection Factor (SPF) from cocoa bean extract formulated in cream form and in combination with Avobenxone and Octyl Methoxycinnamate (OMC). Making cocoa bean extract was extracted by maceration using 80% ethanol solvent, making sunscreen extract of cocoa bean extract made in three formulations with concentrations of 10%, 15% and 20%, evaluating cream preparations and determining SPF values (Sun Protection Factor). using UV-Vis spectrophotometry.The results of the study showed differences in SPF values between cocoa bean extract creams. The concentration that has the highest SPF value is 20% with an SPF value of 15.22. The SPF value obtained from each formula is in the maximum category, the recommended value is 15.00. The best SPF value is found at a concentration of 20%, which is 15.22. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/278 10.36656/jpfh.v2i2.278 Jurnal Penelitian Farmasi Dan Herbal; Vol 2 No 2 (2020): Jurnal Penelitian Farmasi & Herbal; 50-58 2654-7619 10.36656/jpfh.v2i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/278/184 10.36656/jpfh.v2i2.278.g184 Copyright (c) 2020 Dian Ika Perbina Meliala, Wahyudi Wahyudi, Nelva Nelva

oai:ojs2.ejournal.delihusada.ac.id:article/306 2021-12-24T12:29:37Z JPFH:FAR driver

Uji Efektivitas GELL Obat Jerawat Dari Ekstrak Etanol Buah Pare (Momordica charantia L.) Terhadap Pertumbuhan Bakteri Propionibacterium acnes sari, herviani Fahdi, Firdaus Bacterial infection is a major factor in causing acne. The causes of acne are many (multifactorial), including genetic, endocrine, dietary factors, the activity of the sebaceous glands themselves, psychological factors, mucin, infection by Propionibacterium acne, cosmetics, and other chemicals. Pare extract can be formulated as a gell pimple, which can inhibit the growth of propionibacterium acne. The samples in this study were gell preparations of the ethanol extract of bitter melon with a concentration of 5%, 7.5%, 10%. Based on the results obtained, the addition of the ethanol extract concentration of bitter melon fruit depends on the extract produced. The higher the concentration of gell preparations, the better it is to inhibit bacterial growth. The  results showing that pare fruit extract with a concetration of 5%, 7,5%, 10%, and as gell verile 0,025% get a variety of results. And a good resistance zone on the three concentrations that are most close to verile effectiveness is 10% concentration. In conclusion, bitter melon extract can be formulated as an acne medication that can inhibit the growth of the Propionibacterium acnes bacteria. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/306 10.36656/jpfh.v3i1.306 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 1-6 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/306/211 10.36656/jpfh.v3i1.306.g211

oai:ojs2.ejournal.delihusada.ac.id:article/307 2021-12-24T12:29:37Z JPFH:FAR driver

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN MELINJO (Gnetum gnemon L.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus dan Streptococcus mutans TAHUN 2020 Fahdi, Firdaus Sari, Herviani The Gnetum gnemon can be used as a medicine that has the function of anti-bacterial. The chemical content inside which is anti-bacterial is flavonoids and tannins. This study aims to find out the antibacterial from the ethanol extract of melinjo leaves can inhibit the growth of Staphylococcus aureus and Streptococcus mutans with a concentration of 300 mg/ml, 400 mg/ml, and 500 mg/ml. The test of anti-bacterial activity for the growth Staphylococcus aureus and Streptococcus mutans is done by using the disc diffusion method. The results showed that melinjo leaf contains an alkaloid, flavonoid, tannin, steroid and saponin compounds. The results of the simplicia powder characteristics obtained a total ash content of 7.495%, ash content insoluble in acid 0.785%, ethanol-soluble extract 4.324%, water-soluble extract 17.690%. The results of the antibacterial activity test of the ethanol extract of melinjo leaves obtained can inhibit the growth of Staphylococcus aureus and Streptococcus mutans namely at a concentration of 300 mg/ml, 400 mg/ml, and 500 mg/ml into the medium inhibition zone category. Ethanol extract of melinjo leaves has antibacterial activity against the growth of Staphylococcus aureus and Streptococcus mutans with an average diameter of inhibition zone of 9.7 mm (medium category) against Staphylococcus aureus and 6.7 mm (medium category) against bacteria Streptococcus mutans. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/307 10.36656/jpfh.v3i1.307 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 7-12 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/307/214 10.36656/jpfh.v3i1.307.g214 Copyright (c) 2020 Firdaus Fahdi

oai:ojs2.ejournal.delihusada.ac.id:article/310 2021-12-24T12:29:37Z JPFH:FAR driver

UJI EFEKTIVITAS SALEP EKSTRAK ETANOL RIMPANG JERINGAU (Acorus calamus L.) TERHADAP PENYEMBUHAN LUKA SAYAT Meliala, Linta Introduction: Jeringau rhizome plants are one of the traditional plants which are used as antibacterial. Method: The extraction process was carried out by maceration using 80% ethanol. The effectiveness of jeringau rhizome testing was divided into 5 treatments, the positive group used betadine ointment, negative control using an ointment base, and the test group used ethanol extract ointment with 5%, 10% and 15% concentration. Cut wounds given to the rabbit's back with a 2 cm long wound and 2 mm deep, the ointment applied twice a day for 13 days and measured using a ruler or calipers. Result: The results show that Jeringau rhizome contains flavonoid, tannin, saponin, and alkaloid metabolites which can be used as wound heal wound healers. This study aims to determine its effectiveness as a wound healer wound. Conclusions: indicate that the ointment extract jeringau rhizome at a concentration of 15% is the most effective control as a wound healer but the ointment extract of jeringau rhizome ethanol extract is less effective when compared to betadine ointment as a wound healer in rabbits. . Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/310 10.36656/jpfh.v3i1.310 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 13-20 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/310/215 10.36656/jpfh.v3i1.310.g215 Copyright (c) 2020 Linta Meliala

oai:ojs2.ejournal.delihusada.ac.id:article/313 2021-12-24T12:29:37Z JPFH:FAR driver

PENETAPAN KADAR KAFEIN PADA BUBUK TEH HITAM YANG BEREDAR DI PASAR DELI TUA MENGGUNAKAN SPEKTROFOTOMETRI UV MELIALA, DIAN IKA PERBINA Tea is a drink that is very familiar in the world and is very common in everyday life. Tea is also the most consumed and favored beverage by the public after water. Besides being beneficial, tea also contains compounds that have a negative impact on the body, namely caffeine compounds. Caffeine is an alkaloid of the methylxanthine group which plays a role in increasing the work of psychomotor in the body, and side effects that can be caused are anxiety, irregular heartbeat, difficulty sleeping, tremors, diuresis and others. The purpose of this study was to determine the caffeine content in black tea powder circulating in the Old Deli market. This type of research is descriptive with a purposive sampling method. The analytical method used is qualitative with murexide and quantitative ultraviolet spectrophotometry with a wavelength of 267nm. The results of a qualitative analysis of all positive samples contained caffeine. The average quantitative yield of caffeine in brand A black tea powder was (4,82 ±0,0356)%, B brand black tea powder (4,89 ± 0,0173)% and C brand black tea powder (4,93 ± 0,0531)%. The validation test results obtained linearity r = 0,9984, LOD and LOQ is 0,8074 mcg/ml and 2,6914 mcg/ml ,% recovery = 100,07%, RSD = 0,33%. Based on the results of research conducted, it can be concluded that ultraviolet spectrophotometry can be used to determine caffeine levels in black tea powder. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/313 10.36656/jpfh.v3i1.313 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 21-28 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/313/216 10.36656/jpfh.v3i1.313.g216 Copyright (c) 2020 DIAN IKA PERBINA MELIALA

oai:ojs2.ejournal.delihusada.ac.id:article/315 2021-12-24T12:29:37Z JPFH:FAR driver

EFEKTIVITAS EKSTRAK ETANOL DAUN EFEKTIVITAS EKSTRAK ETANOL DAUN SIDAGURI (Sida rhombifolia L.) TERHADAP PENURUNAN KADAR ASAM URAT PADA TIKUS JANTAN GALUR WISTAR HIPERURISEMIA Barus, Bunga Rimta Sidaguri leaves (Sida rhombifolia L.) Have been shown to contain flavonoid compounds, where they are efficacious as hyperuricemia. This study aims to determine effectiveness ethanol extract of sidaguri leaves as antihyperuricemia in white rats. The study was conducted using the method of potassium oxanate induction and measured using glucometers. 15 animals were divided into 5 groups, namely negative control, positive control, group I combination of ethanol extract of sidaguri leaves 50 mg / kg body weight, group II ethanol extract of sidaguri leaves 100 mg / kg body weight, group III ethanol extract of sidaguri leaves 200 mg / kg body weight for 5 hours. Examination of antihyperuricemia effects is done by comparing the uric acid levels value of the rats before and after treatment. The results of this study indicate that the three dose ethanol extract of sidaguri leaves provide an antihyperuricemia effect and based on one-way Anova, Tuckey and LSD data analysis, shows that the dose of 50 mg / kg body weight is effective as antihyperuricemia and does not have a significant difference (p> 0.05). The conclusion of this study is that the dose is the most effective in decreases uric acid levels in white rats, which is a dose of 200 mg / kg body weight because it mostly decreased uric acid levels. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/315 10.36656/jpfh.v3i1.315 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 29-37 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/315/217 10.36656/jpfh.v3i1.315.g217 Copyright (c) 2020 Bunga Rimta Barus

oai:ojs2.ejournal.delihusada.ac.id:article/316 2021-12-24T12:29:37Z JPFH:FAR driver

FORMULASI OBAT KUMUR GAMBIR DAN UJI EFEKTIVITAS TERHADAP BAKTERI Staphylococcus aureus Harnis, Zola Efa Oral hygiene and dental health are very important, there are various kinds of patogen  bacteria in the oral cavity, including the bacteria that cause thrush, Staphylococcus aureus. Gambir is the result of extraction containing polyphenol compounds. The main components contained in gambir consist of alkaloids, flavonoids, tannins and saponins. The use of gambir as a mouthwash preparation is an alternative to replace mouthwash preparations which generally contain an antiseptic in the form of alcohol which can trigger oral cancer. This research is to formulate gambir as a mouthwash and determine the differences in the effectiveness of antibacterial on the growth of Staphylococcus aureus with variations in the concentration of 5%, 10%, 15%. Antibacterial activity test using NA media with agar diffusion method. Physical requirements tests include organoleptic tests, pH tests and viscosity testsshowed that the preparation of 5%, 10% and 15% gambir mouthwash had a pH outside the optimum bacterial growth range of 5. Viscosity of mouthwash preparations of 1.30-5.10 Cp. The antibacterial activity of Staphylococcus aureus in F1 did not produce inhibitory zones, F2 was 5.46 mm, F3 was 9.60 mm and F4 was 10.76 mm while in f5 the positive control was 12.10 mm. Conclusio of this study is gambier mouthwash concentration of 5%, 10% and 15% can inhibit the growth of staphylococcus aureus bacteria. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/316 10.36656/jpfh.v3i1.316 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 38-47 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/316/218 10.36656/jpfh.v3i1.316.g218 Copyright (c) 2020 Zola Efa Harnis

oai:ojs2.ejournal.delihusada.ac.id:article/317 2021-12-24T12:29:37Z JPFH:FAR driver

EFEKTIVITAS SALEP KOMBINASI EKSTRAK DAUN BANGUN – BANGUN (Coleus amboinicus Lour.) DAN DAUN KELAPA SAWIT (Elaeis guineensis Jacq.) SEBAGAI OBAT LUKA SAYAT Sari, Rika Puspita Bangun-bangun leaves and palm leaves contain various secondary metabolites such as tannins, alkaloids and flavonoids which can healing wound. The aim of this study was to determine the effect of ointment combination of ethanol extract of leaves of bangun- bangun (Coleus amboinicus Lour.) And ethanol extract of palm leaves (Elaeis guineensis Jacq.) In healing wound. The bangun- bangun leaves and the palm leaves are separated from the petiole and then dried in a drying cupboard so that it becomes a simplisia. Simplisia is extracted by maceration method then evaporated with a rotary evaporator and evaporated again on a water bath to produce a thick extract. Thick extracts from the leaves of bangun- bangun and palm leaves are then formulated into ointment preparations with varying concentrations. Each rabbit was shaved on its back then cleaned with 70% alcohol. Furthermore, rabbits were anesthetized using 0.5 ml Lidocain HCL as much as 0.5 ml subcutaneously. Next mark the part that will be injured with a diameter of 2 cm, by lifting the rabbit skin using tweezers and then made a wound using surgical scissors that have been sterilized first with 70% alcohol. Wound diameter measurements showed that all treatment groups from day 1 to day 23 experienced changes in wound diameter. The combination ointment of ethanol extract of leaves wake-up (EEDB) 10% and ethanol extract of palm oil leaves (EEDKS) 10% have a more effective effect in wound healing than single dose. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/317 10.36656/jpfh.v3i1.317 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 48-56 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/317/219 10.36656/jpfh.v3i1.317.g219 Copyright (c) 2020 Rika Puspita Sari

oai:ojs2.ejournal.delihusada.ac.id:article/318 2021-12-24T12:29:37Z JPFH:FAR driver

EFEK PENYEMBUHAN LUKA BAKAR GEL KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Vernonia Amygdalina) DAN EKSTRAKETANOLDAUNBANGUN–BANGUN(ColeusamboinicusLour) Harahap, Nina Irmayanti african leaves ( Vernonia Amygdalina )and wake-up leaves (Coleus amboinicus Lour)are plants traditional plants that are used as medicine. Leaves african which is contain flavonoid, saponin, tanin and leaves wake up which is contain flavonoid, tanin, saponin and steroid. This study to find aims out as effect healing of burns.Method : Sample in this study was african leaves and wake-up leaves which were taken purposively without comparing sampel from other regions, then extrated by maceration using ethanol 96 %. Result : Testing of rhe healing effects of burns can be divided in five treatment, positive group using biolacenton , negatif group using basis gel and the last group using the extract ethanol gel EEDA and EEDB concentrations of 4%+2,5%,8%+5%,16%+10%. Given burns to the back of rabbits length with of 2cm, and the gel is applied twice a day for 11 day and diameter measured of the wound. Conclusion : The combination of EEDA and EEDA the ethanol extract the concentration of 16% + 10% was the effective control for healing burns. When compared bioplacenton gel as a healing wound in rabbit. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/318 10.36656/jpfh.v3i1.318 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 57-61 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/318/220 10.36656/jpfh.v3i1.318.g220 Copyright (c) 2020 Nina Irmayanti Harahap

oai:ojs2.ejournal.delihusada.ac.id:article/320 2021-12-24T12:29:37Z JPFH:FAR driver

UJI EFEKTIVITAS GEL KOMBINASI EKSTRAK ETANOL DAUN BANGUN-BANGUN (Coleus amboinicus L.) DAN DAUN KELAPA SAWIT (Elaeis guieensis Jacq) SEBAGAI OBAT LUKA BAKAR TAHUN 2020 Gultom, Evi Depiana Coleus amboinicus L leaves and Elaeis guieensis Jacq leaves contain various secondary metabolites such as saponins, tannins, alkaloids and flavonoids that function in wound healing. The purpose of this study was to determine the healing effect of burns using a gel preparation combination of ethanolic extract of Coleus amboinicus L. (EECAL)  And ethanolic extract of Elaeis guineensis Jacq. (EEEGJ) In healing burns. Coleus amboinicus L leaves and Elaeis guieensis Jacq leaves contain are separated from the petiole and then dried in a drying cupboard so that it becomes a simplicia. Simplisia is extracted by maceration method then evaporated with a rotary evaporator and evaporated again on a water bath to produce a thick extract. EECAL and EEEGJ are then formulated into gel preparations with varying concentrations. Each rabbit was shaved on its back then cleaned with 70% alcohol. Furthermore, rabbits were anesthetized using 0.5 ml Lidocain HCL as much as 0.5 ml subcutaneously. Then mark the part that will be injured with a diameter of 2 cm, by lifting the rabbit skin using tweezers and then made a wound using a hot iron plate that has been sterilized beforehand with 70% alcohol. Wound diameter measurements showed that all treatment groups from day 1 to day 20 experienced changes in wound diameter. EECAL 15% and EEEGJ 10% have a more effective effect in healing of burn than in their single form.            Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/320 10.36656/jpfh.v3i1.320 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 62-68 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/320/221 10.36656/jpfh.v3i1.320.g221 Copyright (c) 2020 Evi Depiana Gultom

oai:ojs2.ejournal.delihusada.ac.id:article/321 2021-12-24T12:29:37Z JPFH:FAR driver

EFEKTIVITAS KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalinum Del.) DAN EKSTRAK ETANOL DAUN KELAPA SAWIT(Elaeis guineensis Jacq.)TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS PUTIH Ardiani, Rani African leaves (Gymnanthemum amygdalinum Del.) And palm oil leaves (Elaeis guineensis Jacq.) Have been shown to contain flavonoid compounds, where they are efficacious as antidiabetic. This study aims to determine the combined effectivenessof ethanol extract of African leaves and palm oil leaves as antidiabetic in white rats.The study was conducted using the method of alloxan induction and measured using glucometers. 15 animals were divided into 5 groups, namely negative control, positive control, group I combination of ethanol extract of african leaves and oil palm leaves 25 + 25 mg/kg weight, group II combination of ethanol extract of african leaves and palm oil leaves of 50 + 50 mg/kg weight, group III combination of ethanol extract of African leaves and leaves of oil palm 100 + 100 mg/kg weight for 15 days. Examination of antidiabetic effects is done by comparing the KGD value of the rats before and after treatment. The results of this study indicate that the three doses have antidiabetic effects. Data on the differences in the KGD of rats were carried out statistically using the Shapiro Wilk normality test and the Levene homogeneity test and continued with the ANOVA test. The conclusion of this study is that the dose is the most effective in reducing blood glucose levels in rats, which is a dose of 100 + 100 mg/dl because it mostly decreases blood glucose levels. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/321 10.36656/jpfh.v3i1.321 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 69-74 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/321/222 10.36656/jpfh.v3i1.321.g222 Copyright (c) 2020 Rani Ardiani

oai:ojs2.ejournal.delihusada.ac.id:article/326 2021-12-24T12:29:37Z JPFH:FAR driver

PEMBUATAN SEDIAAN BALSEM STICK DARI SEREH (Cymbopogon citratus (DC.) Stapf) SEBAGAI AROMATERAPI purba, okto Introduction: Lemongrass plants contain essential oils that can be used as aromatherapy. In the context of efforts to improve public health services in Indonesia, traditional medicine has the opportunity as one of the potential alternative treatments. Society uses traditional medicine in the form of herbal medicine, stew, juice or by rubbing directly on the affected part. Method: Sample in this study was African leaves and palm leaveswhich were taken purposively without comparing samples from other regions, To get the essential oil of lemongrass done by distillation. Result: Aromatherapy balm from essential oil is formulated with some concentrations of 0%, 15%, 20% and 25% of the evaluation of balm which has been done to 3 qualified balm formulas and has good physical quality. Concludes: Citronella essential oil can be made into a supply of balm stick with various concentrations, namely 15%, 20% and 25%. Stick balm made from essential oils of lemongrass can give an aromatherapy effect which is characterized by a refreshing aroma when inhaling the balm preparations and can provide a warm sensation. The best concentration as an aromatherapy stick balm preparation is 25% because it gives the highest aroma and test preferences. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/326 10.36656/jpfh.v3i1.326 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 75-81 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/326/223 10.36656/jpfh.v3i1.326.g223 Copyright (c) 2020 okto purba

oai:ojs2.ejournal.delihusada.ac.id:article/327 2021-12-24T12:29:37Z JPFH:FAR driver

PERBANDINGAN EFEK PENYEMBUHAN LUKA BAKAR ANTARA GEL EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalinum Del.)DENGAN GEL EKSTRAK ETANOL DAUN KELAPA SAWIT ( Elaeis guineensis Jacq.) SERTA KOMBINASINYA PADA KELINCI TAHUN 2019 Ginting, Suventi Syafrina African leaves (Gymnanthemum amygdalinum Del.) And palm leaves (Elaeis guineensis Jacq.) Have secondary metabolites, namely alkaloids, steroids / terpenoids, flavonoids, tannins, and saponins in this study aimed to determine the effectiveness of healing burns. The extract was made by maceration method using 96% ethanol. This test used 3 rabbits, each of which had been burnt into 6 wound areas on the back of the rabbit. First group (positive control), second group (without treatment), third group gel with Arfika leaf ethanol extract concentration of 5%, fourth group gel with palm ethanol extract concentration of 7.5%, fifth group of groups gel with a combination of Arfika leaf ethanol extract concentration of 5% and 7.5% palm oil leaf ethanol extract The burns that have been made are smeared with as much test preparation as possible once a day. The next day the diameter of the wound was measured, then smeared with an adequate amount of gel. This is done until the diameter of the wound is equal to zero or the wound has been covered by new tissue. The results of testing the effectiveness of healing burns showed that all treatment groups had a faster recovery day compared to negative controls. The conclusion of this study is the combination of 5% arfika ethanol extract gel and 7.5% oil palm leaf ethanol extract is the group with the fastest fastest day on the 19th day. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/327 10.36656/jpfh.v3i1.327 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 82-90 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/327/224 10.36656/jpfh.v3i1.327.g224 Copyright (c) 2020 Suventi Syafrina Ginting

oai:ojs2.ejournal.delihusada.ac.id:article/330 2021-12-24T12:29:37Z JPFH:FAR driver

PERBANDINGAN EFEKTIVITAS EKSTRAK DAN JUS BUAH BIT (Beta vulgaris L.) TERHADAP PENURUNAN KOLESTEROL TIKUS PUTIH Margata, Linda Br Haloho, Dewi Sartika Parhan, Parhan Kandungan pada buah bit diketahui mampu menurunkan kolesterol dengan cara menghambat pembentukan asam glutarat. Penelitian ini bertujuan untuk membandingkan efek penurunan kolesterol ekstrak dan jus buah bit pada tikus putih. Penelitian ini menggunakan 24 ekor tikus yang dibagi menjadi empat kelompok. Pada penelitian ini tikus diinduksi dengan propiltiourasil (PTU) selama 10 hari lalu masing-masing kelompok diberikan: CMC Na, simvastatin, ekstrak buah bit, dan jus buah bit selama 15 hari. Data penelitian diolah dengan program SPSS menggunakan ANAVA satu-jalur dengan signifikansi 0,05. Kolesterol total sebelum perlakuan pada jus buah bit yaitu 306 mg/dl dan pada ekstrak 311 mg/dl. Kadar kolesterol total setelah perlakuan yaitu 103 mg/dl pada jus dan 148 mg/dl pada ekstrak. Pemberian ekstrak buah bit dan jus buah bit secara signifikan berpengaruh terhadap penurunan kadar kolesterol total. Pemberian ekstrak dan jus buah bit dapat menurunkan kadar kolesterol tikus putih. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/330 10.36656/jpfh.v3i1.330 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 91-99 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/330/225 10.36656/jpfh.v3i1.330.g225 Copyright (c) 2020 Linda Margata, Dewi Sartika Br Haloho, Parhan Parhan

oai:ojs2.ejournal.delihusada.ac.id:article/331 2021-12-24T12:29:37Z JPFH:FAR driver

UJI EFEKTIVITAS ANTIDEPRESAN EKSTRAK BATANG SERAI (Cymbopogon nardus (L.) Rendle) TERHADAP MENCIT PUTIH JANTAN (Mus musculus) Simorangkir, Delisma Depression is a mood disorder that is characterized by profound and sustained sadness and sadness until the loss of life passion. Lemongrass which contains eugenol is thought to have the potential as an antidepressant that works by inhibiting the Mono Amine Oxidase enzyme. This study aims to determine the effectiveness of antidepressant citronella extract (Cymbopogon nardus (L.) Rendle) on male white mice. This study used 5 treatment groups namely CMC Na 0.5%, amitriptilyn, lemongrass extract dose 1.5 mg/kgBB, 15 mg/kgBB and 150 mg/kgBB. Antidepressant testing was determined based on immobility time using the forsed swim test method. Data analysis using statistics was tested for normality and continued with the One Way Anova method with a 95% confidence level. The results showed that the most effective treatment group as an antidepressant was amitriptilyn followed by lemongrass extract dose 150 mg/kgBB. The conclusion of this study is that lemongrass extract dose 150 mg/kgBB has the effectiveness as an antidepressant but is no more effective than the comparison of amitrip Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/331 10.36656/jpfh.v3i1.331 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 100-105 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/331/227 10.36656/jpfh.v3i1.331.g227 Copyright (c) 2020 Delisma Simorangkir

oai:ojs2.ejournal.delihusada.ac.id:article/332 2021-12-24T12:29:37Z JPFH:FAR driver

PENGUJIAN EFEKTIVITAS DIURETIK KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalinum Del.) DAN DAUN KELAPA SAWIT (Elaeis guineensis Jacq.) PADA TIKUS JANTAN Simorangkir, Delisma African Leaf and palm leaf crops have a secondary metabolite content such as alkaloids and flavonoids that are efficacious as diuretics. The purpose of this study is to know the effectiveness of diuretics from the combination  African leaf ethanol extract and palm leaf ethanol extract. Methods used Eksperiemental. The test of diuretic activity is conducted divided into 6 treatment groups. Each group consists of 3 tails of white rats. Group 1 (positive control) administered Furosemide 3.6 mg/kgBB, Group 2 (negative control) was given suspension Na-CMC 0.5%, group 3 without treatment as well as groups of 4.5, and 6 in a row administered a combination of African leaf extract doses and extracts Oil palm leaf ethanol in a row of "50 mg/kgBB + 67, 5mg/kgBB"; "100mg/kgBB + 135 mg/kgBB"; and "200 mg/kgBB + 270 mg/kgBB". Each mouse is then given a 20ml NaCl/kgBB as an oral loading dose. Measured urine volume is recorded every hour for 6 hours after it continues to measure urine volume. The results showed that the combination of African leaf ethanol extract dosage and palm leaf ethanol extract had a diuretic effect if it was compared with negative control. The conclusion of the study was the results of the study showed that the combination of African leaf extract dosage and palm leaf extract is the most effective dose of Group 6 (African leaf extract 200 mg/kgBB + palm leaves 270 mg/kgBB ). Because it produces the highest urine volume of 23.01 ml. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/332 10.36656/jpfh.v3i1.332 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 106-111 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/332/228 10.36656/jpfh.v3i1.332.g228 Copyright (c) 2020 Delisma Simorangkir

oai:ojs2.ejournal.delihusada.ac.id:article/361 2021-12-24T12:29:37Z JPFH:FAR driver

UJI EFEKTIVITAS EKSTRAK ETANOL DARI KULIT PISANG KEPOK (Musa Paradisiaca) UNTUK PENYEMBUHAN LUKA SAYAT PADA TIKUS sembiring, bunga mari Banana peel turns out to have many benefits, one of which is that it can be used to accelerate the wound healing process. Banana peel (Musa Paradisiaca L.) ripe yellow skin is rich in flavonoid compounds, as well as other phenolic compounds, besides containing a lot of carbohydrates, minerals such as potassium and sodium and cellulose. This study aims to determine the wound healing effect of cuts using the Ethanol Extract of Kepok Banana Skins in Rats. Determine the concentration of ethanol extract of Kepok banana peel which is the most effective in healing wound cuts in mice. Knowing a significant difference to the acceleration of wound healing between ethanol extracts of Kepok banana peel and betadin. Research methods conducted included characterization, effectiveness test of ethanol extract of Kepok banana peel, manufacture of extract by maceration using ethanol 96% solvent, test of effectiveness of ethanol extract of kepok banana peel on cut wounds in mice. Data analysis using SPSS is Anova One Way Test. From the results of this study the ethanol extract of Kepok banana peel can have an effect on wound healing in mice. Ethanol extract of Kepok banana peel is faster than betadin in healing wound cuts in mice. Ethanol extract of Kepok banana peel with a dose of 750 Mg / kg BW is the most effective in healing wound cuts in rats. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/361 10.36656/jpfh.v3i1.361 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 112-121 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/361/229 10.36656/jpfh.v3i1.361.g229 Copyright (c) 2020 bunga mari sembiring

oai:ojs2.ejournal.delihusada.ac.id:article/362 2021-12-24T12:29:37Z JPFH:FAR driver

the PENGARUH PEMBERIAN SIMETIDIN TERHADAP PROFIL FARMAKOKINETIKA PARASETAMOL DENGAN METODE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) TAHUN 2020 Surbakti, Christica Ilsana Paracetamol is a safe analgesic and antipyretic drug with low side effects, effective and well tolerated. In some cases there is a drug interaction between paracetamol and other drugs. The purpose of this study is to determine the effect of cimetidine administration on paracetamol pharmacokinetic profiles. The method used in this study was an experimental method using 3 rabbits. Rabbits are divided into 3 groups. The first treatment group was given paracetamol suspension, the second treatment group was giving cimetidine 1 hour before paracetamol and the third group was giving cimetidine and paracetamol simultaneously. The dose of the drug has been adjusted to each rabbit. Measurement of plasma paracetamol drug levels was carried out using a High Performance Liquid Chromatography (HPLC) tool. The results of the study showed that the pharmacokinetic parameter values ​​did not show any significant effect on each group. Cimetidine administration simultaneously affects paracetamol pharmacokinetic parameters but not significantly. Likewise with the administration with a time span of 1 hour, did not show any significant changes in the pharmacokinetics of paracetamol. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/362 10.36656/jpfh.v3i1.362 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 122-129 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/362/230 10.36656/jpfh.v3i1.362.g230 Copyright (c) 2020 Christica Ilsana Surbakti

oai:ojs2.ejournal.delihusada.ac.id:article/368 2021-12-24T12:29:37Z JPFH:FAR driver

AKTIVITAS ANTIBAKTERI EKSTRAK KULIT BUAH PEPAYA CALIFORNIA (Carica papaya L) TERHADAP BAKTERI Escherchia coli Marbun, Romaulianna Theresia Situmorang, Novidawati Br Infectious diseases caused by bacteria, require antibiotics for treatment. Incorrect use of antibiotics causes. the occurrence of resistance. From the research, it was found that many medicinal plants can be used to cure infectious diseases. One of them is California Papaya Fruit Skin (Carica papaya L). The purpose of this study was to determine the active substance in the skin of the Carica Papaya Fruit as an antibacterial agent and to determine the activity of KBPC extract against E. coli bacteria. This research method is a laboratory experiment where the sample in this study is 3 kg. Phytochemical test results with positive ethanol extraction containing flavonoids, saponins, steroids. Where favonoids can be potential as antibacterial through 3 mechanisms, namely by inhibiting nucleic acid synthesis, inhibiting cell membrane function and inhibiting energy metabolism. The results of the antibacterial activity test against E. coli bacteria were carried out with several concentrations, namely 20%, 40%, 60%, 80%, 100%, the test results obtained from the concentration of 20% of 8.76 mm the highest inhibitory power at the concentration 100% of 19.33 mm. Conclusion KBPC extract has antibacterial activity against E. Coli bacteria. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-11-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/368 10.36656/jpfh.v3i1.368 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 130-134 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/368/231 10.36656/jpfh.v3i1.368.g231 Copyright (c) 2020 Romaulianna Theresia Marbun; Novidawati Br Situmorang

oai:ojs2.ejournal.delihusada.ac.id:article/387 2021-12-24T12:29:37Z JPFH:FAR driver

ANTIBACTERIAL ACTIVITY TEST OF LIME JUICE EXTRACT AGAINST ESCHERICHIA COLI Nerdy, Nerdy Tarigan, Palas Elysa, Elysa Lestari, Puji Nurmalisa, Siti Lime (Citrus aurantifolia Swingle) is known to have seceral phytochemical contents (flavonoids and saponins) that can be memiliki berbagai aktivitas farmakologis yang bermanfaat. Salah satu aktivitas farmaokologis yang diberikan oleh flavonoid adalah sebagai antibacterial activity. The aims of this research was to determine the antibacterial activity of lime juice against Escherichia coli bacteria. This research used an experimental laboratory research method using antibacterial effectiveness trials against the growth of Escherichia coli bacteria. The research design for antibacterial effectiveness used the lime fruit extract method with 4 treatment groups, positive control and negative control. Antibacterial effectiveness was observed the inhibition zone diameter by disc diffusion method. Results of the Escherichia coli antibacterial effectiveness test obtained at a concentration of 100% had antibacterial activity with an average diameter of the inhibition zone 19.9 mm. The lowest concentration that still provides antibacterial resistance against Escherichia coli is at a concentration of 12.5% ​​with an average diameter of the inhibition zone of 17.9 mm. The results obtained indicated that the antibacterial effectiveness test on lime fruit extract is very strong. At a concentration of 100% it has the best antibacterial activity, the inhibition zone diameter similar with the inhibition zone of 500 mg tetracycline. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2020-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/387 10.36656/jpfh.v3i1.387 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal; 135-139 2654-7619 10.36656/jpfh.v3i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/387/232 10.36656/jpfh.v3i1.387.g232 Copyright (c) 2020 Nerdy Nerdy, Palas Tarigan, Elysa Elysa, Puji Lestari, Siti Nurmalisa

oai:ojs2.ejournal.delihusada.ac.id:article/652 2021-12-17T08:58:26Z JPFH:FAR driver

FORMULASI DAN UJI STABILITAS LOTION SARI BUAH TOMAT (licopersicon esculentum mill) KOMBINASI KUNYIT (Curcuma domestica Vall) SEBAGAI PELEMBAB KULIT Harahap, Nina Irmayanti Antioxidants is contained in various types of fruit and vegetables included of juice tomatoes (Lycopersicum esculentum Mill)that have nutritional value and benefits for the body like lycopene, and vitamin C as antioxidants. Lycopene is function as a strong antioxidant to control free radical. Tumeric (Curcuma domestica Vall) is known have enough curcumin and strong antioxydants content too, and so it has some pharmacological effects.  Tomatoes and Tumeric  extract (EKSBT) can be made as pharmaceutical preparations in hand and body lotion (H&B lotion),because antioxidants are important components that are used for body protection from ultra violet light and can be applied in the form of a lotion. The purpose of this study was to saw the stability of the H&B lotion combination of that Variations.Combination tomatoes and turmeric extract formulated with concentrations lotion are of 5%, 10%, and 15%. The lotion of EKSBT these  combination were evaluated some test there are organoleptic, homogeneity, pH test, spreadability, irritation and preference test.EKSBT combination can be formulated into lotion preparations. The various of all concentrations lotion EKSBT showed that stable during instorage, give a homogeneous yellow color  with pH of 5-6 and a spread of 5-6 cm, does not irritate the skin and is preferably the volunteer.Physical stability EKSBT lotion test all concentration are stable, the preferred test of odor, easy to be smeared and moisturizing shows that the most preferred EKSBT lotion is the highest concentration 15%.  Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2021-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/652 10.36656/jpfh.v3i2.652 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 2 (2021): Jurnal Penelitian Farmasi & Herbal; 1-7 2654-7619 10.36656/jpfh.v3i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/652/394 10.36656/jpfh.v3i2.652.g394 Copyright (c) 2021 Nina Irmayanti Harahap

oai:ojs2.ejournal.delihusada.ac.id:article/653 2021-12-17T08:58:26Z JPFH:FAR driver

FORMULASI KRIM PEWARNA RAMBUT EKSTRAK ETANOL DAUN HATI UNGU (Tradescantia pallida) Wahyuni, Wahyudi Hati ungu contain natural dyes derived from anthocyanins. Anthocyanin is a pigment that is classified into flavonoids which in general gives a specific color to plants. The natural color found in this purple liver plant can be used as a natural coloring agent in cosmetics. Hair dye cream preparations were chosen because they are popular and easy to use. The purpose of this study is to determine ethanol extracts of hati ungu can be made as a preparation for hair dye creams, and which formula gives the best color. The research method was carried out including making ethanol extract of hati ungu (Tradescantia pallida) by maceration using 96% ethanol.The results of research on 4 hair dye cream formulations, preparations met the test requirements. The results of the basting test on hair with a vulnerable time for 1-4 hours showed that at the fourth hour the results of hair coloring give a good color. In the color stability test of washing, after washing with shampoo fifteen times all four formulas have a fixed color up to 9 times washing. The results of color stability to sunlight show that after the hair is exposed to sunlight the color looks slightly changed, hair color becomes darker than before. From the results of the research the concentration of ethanol extract of hati ungu which gives the best purple color is ethanol extract cream of hati ungu 20%. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2021-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/653 10.36656/jpfh.v3i2.653 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 2 (2021): Jurnal Penelitian Farmasi & Herbal; 8-13 2654-7619 10.36656/jpfh.v3i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/653/395 10.36656/jpfh.v3i2.653.g395 Copyright (c) 2021 Wahyudi Wahyuni

oai:ojs2.ejournal.delihusada.ac.id:article/654 2021-12-17T08:58:26Z JPFH:FAR driver

Perbandingan Konsentrasi Ekstrak Etanol Daun Bau-Bau (Chromolaena odorata (L.) King & H.E. Robins) Dan Ekstrak Etanol Temu Putih (Curcuma zedoria (Berog) Rosc) terhadap Penyembuhan Luka Bakar pada Kelinci Barus, Bunga Rimta Daun Bau-Bau (Chromolanea odorata (L) King & H Robins) mengandung senyawa minyak atsiri, flavonoid, alkaloid, fenol, saponin, dan tannin. Temu putih (Curcuma zedoria (Berog.)Rosc) mengandung kurkumin, tritepenoid, flavonoida, saponin dan minyak astiri. Tujuan penelitian ini untuk membandingkan efektivitas Ekstrak Etanol Daun Bau-Bau dan Ekstrak Etanol Rimpang Temuputih. Ekstraksi sampel menggunakan etanol 96%. Hasil ekstraksi dibagi 7 kelompok konsentrasi yaitu 25%,15%, 10%  dan Aquadest sebagai kontrol negatif.Menurut Hasil Analisis Data Anova One Way (Uji Tuckeys B) Diameter luka bakar dari hari pertama sampai ke 14 hari pengamatan mengalami penurunan, kelompok kelinci yang diberi perlakuan dengan ekstrak daun bau-bau konsentrasi 25% pada hari ke- 14 diameter luka bakar mengalami perubahan dengan efektifitas 2 cm (p=0,0). Pada kelompok ekstrak etanol temuputih konsentrasi 25% pada hari ke-14 diameter luka bakar mengalami perubahan dengan efektifitas 1,08 cm (p=0,64). Ekstrak Etanol Daun Bau-Bau Lebih Efektif untuk menyembuhkan luka bakar dibandingkan dengan Ekstrak Etanol Temu Putih.   Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2021-12-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/654 10.36656/jpfh.v3i2.654 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 2 (2021): Jurnal Penelitian Farmasi & Herbal; 14-20 2654-7619 10.36656/jpfh.v3i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/654/396 10.36656/jpfh.v3i2.654.g396 Copyright (c) 2021 Bunga Rimta Barus

oai:ojs2.ejournal.delihusada.ac.id:article/655 2021-12-17T08:58:26Z JPFH:FAR driver

FORMULASI EKSTRAK BUAH NAGA MERAH (Hylocereus polyrhizus ) SEBAGAI SEDIAAN PEMERAH PIPI (BLUSH ON) Sari, Herviani Fahdi, Firdaus Dragon fruit contain high antosianin, sources of antosianin can be optained from pink colored fruit and vegetables to red. The natural properties of antosianin can be used as natural dyes in cosmetic preparation were chosen because it is a cosmetic that is quite popular and most comfortable to use. The purpose of this research is to find out whether dragon fruit can be blush on, not irritated and to find out the best formulations. The methode of this research was done by making dragon fruit extract by maceration for 24 hours using etanol. The extract formulation used is 15%, 25%, and 40%. Ingridienst for making blush on include kaolin, parrafin liquid, zink oxyd, and talcum. Evaluation of blus on preparations include homogenty, pH, dispersion, irritation, polish and hedonic. The results of research 3 blush on formulation, the preparation met the homogenity test with no vissible coarse grains and particlesevently mixed. The pH of the preparation producted is still in the normal pH range of spearat evenly and easily attached to the skin, with each application three time polishing. Based on the favorite test after processing statistical data, formulation the most preferred panelish is blush on formulation 3. Key words: Dragon fruit, blush on, antosianin. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2021-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/655 10.36656/jpfh.v3i2.655 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 2 (2021): Jurnal Penelitian Farmasi & Herbal; 21-28 2654-7619 10.36656/jpfh.v3i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/655/397 10.36656/jpfh.v3i2.655.g397 Copyright (c) 2021 Herviani Sari; Firdaus Fahdi

oai:ojs2.ejournal.delihusada.ac.id:article/656 2021-12-17T08:58:26Z JPFH:FAR driver

FORMULASI SEDIAAN MASKER GEL Peel-off EKSTRAK DAUN KECOMBRANG (Etlingera elatior) SEBAGAI PERAWATAN PADA KULIT WAJAH Sembiring, Bunga Mari Kecombrang (Etlingera elatior) leaves contain flavonoid compounds, saponins, alkoloid, and tannins. Based on the compounds owned kecombrang leaves can be used as a peel off gel mask. The purpose of this study was to make a peel off gel mask formulation of kecombrang (Etlingera elatior) leaf extract as a treatment for facial skin. The gel peel off mask formulation was made with 4 formulations, F0 = 0%, FI = 10%, FII = 15%, FIII = 20%. Extraction method is done using maceration method with 96% ethanol solvent. Evaluation of peel off gel mask preparations, including organoleptic tests (color, odor, shape), pH measurement of preparations, homogeneity test, dry time test, spreadability test. Peel off gel mask preparations that have effectiveness as treatments for facial skin are FIII formulations with a concentration of 15% that meet the evaluation test requirements, and positive control (Naturgo) which has had better effectiveness test results. The results of the evaluation test of peel off gel mask preparation, including organoleptic test (color, odor, shape), pH measurement of the preparation, homogeneity test, dry time test, dispersion test according to the gel preparation parameters. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2021-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/656 10.36656/jpfh.v3i2.656 Jurnal Penelitian Farmasi Dan Herbal; Vol 3 No 2 (2021): Jurnal Penelitian Farmasi & Herbal; 29-34 2654-7619 10.36656/jpfh.v3i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/656/398 10.36656/jpfh.v3i2.656.g398 Copyright (c) 2021 Bunga Mari Sembiring

oai:ojs2.ejournal.delihusada.ac.id:article/746 2021-12-25T12:12:26Z JPFH:FAR driver

PERBANDINGAN SEDIAAN SIRUP ANTIDIARE EKSTRAK DAUN SAWO (Manilkara zapota L.) DENGAN SEDIAAN SIRUP ANTIDIARE DI PASARAN TERHADAP MENCIT PUTIH (Mus musculus L.) Meliala, Linta Syafitri, Anggun Background: the Sapodilla leaves (Manilkara zapota L.) contain chemical compounds of tannins and flavonoids which have antidiarrheal activity. Tannins are astringent and flavonoids inhibit intestinal motility which can reduce fluid and electrolytes. Methods: This purpose research is to determine the effectiveness and comparison of sapodilla leaf extract syrup with Diapet Kids syrup as antidiarrheal against white mice induced by castor oil. The research used experimental method, the sample was macerated using 70% ethanol as solvent. The thick extract was formulated in syrup dosage form, and stability test was carried out. The syrup doses used were 60 mg/kg BW, 90 mg/kg BW, and 120 mg/kg BW, syrup without extract as a negative control and Diapet Kids syrup as a comparison syrup. The effectiveness of antidiarrhea was carried out by using the diarrhea protection method for 6 hours and comparing the effectiveness of the sapodilla leaf extract syrup with the Diapet Kids syrup. The results of research : is showed that the stability of sapodilla leaf extract syrup met the standard requirements. The data analysis using one way ANOVA then continued with Tukey HSD test. The antidiarrheal activity of sapodilla leaf extract syrup at 90 and 120 mg/kg BW and Diapet Kids syrup have significant different with positive control and syrup of sapodilla leaf extract at 60 mg/kg BW dose (p < 0.05). The comparison of syrup of sapodilla leaf extract dose of 120 mg/kg BW with syrup Diapet Kids was not in significantly difference (p > 0.05). The Sapodilla leaf extract syrup at 90 and 120 mg/kg BW had antidiarrheal activity and Sapodilla leaf extract syrup at 120 mg/kg BW had no significant difference with Diapet Kids syrup (p > 0.05). Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2021-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/746 10.36656/jpfh.v4i1.746 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 1 (2021): Jurnal Penelitian Farmasi & Herbal; 1-6 2654-7619 10.36656/jpfh.v4i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/746/505 10.36656/jpfh.v4i1.746.g505 Copyright (c) 2021 Linta Meliala, Anggun Syafitri

oai:ojs2.ejournal.delihusada.ac.id:article/750 2021-12-25T12:12:26Z JPFH:FAR driver

UJI EFEKTIVITAS EKSTRAK ETANOL HERBA KROKOT (Portulaca oleracea L.) SECARA Topical UNTUK Reepitelisasi PENYEMBUHAN LUKA INSISI PADA TIKUS PUTIH (Rattus norvegicus) Ardiani, Rani The krokot is a weed that usually grows in plantations. In scientific language, purslane is called Portulaca oleracea L. Purslane is well-known as a nutritious plant in several countries such as China, Mexico, and Greece. In Indonesia, purslane is also known to have uses, or a substitute for ginseng. This aims of the study to determine the effectiveness of purslane herb ethanol extract ointment on wound healing in white rats. This research was conducted using an experimental method. In this study, phytochemical screening and simplicia characterization were carried out. Incision wound healing effect was tested on 25 male white rats with 5 treatment subgroups, namely positive control, negative control, purslane herb ethanol extract ointment 10%, purslane herb ethanol extract ointment 20%, purslane herb ethanol extract ointment 30%. The ointment base used is Vaseline album, liquid paraffin, and solid paraffin. All formulations of purslane herb 10%, 20% and 30%, met the requirements for evaluation of ointment preparations. Phytochemical screening results showed positive containing flavonoids, tannins and saponins. The results of the characterization of purslane herb simplicia powder obtained water content of 8.37%, water soluble extract content of 11.35%, ethanol soluble extract content of 10.99%, total ash content of 7.46% and acid insoluble ash content of 0.88%. The average results of observation of incision wounds in white rats were concentrations of 10% (22 mm) for 14 days, 20% (0.1 mm) for 14 days, 30% (0.04 mm) for 14 days. While the positive control (betadine ointment) was (0 mm) and the negative control (ointment base) was (0.42 mm). It can be concluded that purslane herb ethanol extract can provide effectiveness and antioxidants for wound healing in white rats. The purslane herb 30% ethanol extract has almost comparable effectiveness with betadine ointment in healing incisional wounds in white rats. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2021-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/750 10.36656/jpfh.v4i1.750 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 1 (2021): Jurnal Penelitian Farmasi & Herbal; 7-11 2654-7619 10.36656/jpfh.v4i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/750/504 10.36656/jpfh.v4i1.750.g504 Copyright (c) 2021 Rani Ardiani

oai:ojs2.ejournal.delihusada.ac.id:article/754 2021-12-25T12:12:26Z JPFH:FAR driver

FORMULASI DAN PERBANDINGAN UJI STABILITAS FISIK SEDIAAN GEL EKSTRAK DAUN KACAPIRING (GARDENIA JASMINOIDES ELLIS) DAN ACNES SPOT GEL DIPASARAN Eliasari, Sofia Background: The gardenia jasminoides ellis contain flavonoids which have antioxidant and the antibacterial effects. Traditional use requires a long preparation, so it is necessary to formulate preparations that are more practical and durable in storage. The gel preparation was chosen in the formulation because it dries easily, forms a film that is easy to wash off and provides a cooling feeling on the skin. The gel component affects of the stability of the gel. The stability tests need to be carried out to ensure the quality, safety and efficacy of the gel meets the expected specifications and is stable during storage. The aims of the study to determine the difference in of the physical stability of the gel preparation of Gardenia jaminoides ellis and acnes spot gel on the market and determine the concentration of gardenia jasminoides ellis extract which has the best physical stability. Methods: The research of the method is experimental laboratory. Simplicia was extracted using 96% ethanol as solvent. The extract was formulated in gel dosage form with a concentration of 0.5% (FI), 1% (FII) and 1.5% (FIII). The results of study: The physical stability of the preparation tested by organoleptic, homogeneity, pH test, adhesion test, viscosity test, hedonic test and gel stability test which were compared with gels on the market. The results of the physical stability of the preparation observed at room temperature, the pH of the market gel was more acidic than the gardenia jasminoides ellis extract. The viscosity of formula 3 is higher in viscosity. In the stability test, it was seen that from the three formulas and gels on the market there was no change in shape, color and odor. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2021-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/754 10.36656/jpfh.v4i1.754 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 1 (2021): Jurnal Penelitian Farmasi & Herbal; 12-19 2654-7619 10.36656/jpfh.v4i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/754/506 10.36656/jpfh.v4i1.754.g506 Copyright (c) 2021 Sofia Eliasari

oai:ojs2.ejournal.delihusada.ac.id:article/757 2021-12-25T12:12:26Z JPFH:FAR driver

EFEKTIVITAS IMUNOSTIMULAN DARI EKSTRAK DAUN BANGUN-BANGUN (Coleus amboinicus L.) PADA TIKUS JANTAN DENGAN STIMUNO SEBAGAI PEMBANDING TAHUN 2021 Syafitri, Anggun Meliala, Linta Background: This modern society does not know much about the benefits of medicinal plants for health, because people are more familiar with drugs from chemicals. Many plants have imunostimulant activities, one of them is bagun-bangun (Coleus amboinicus L.) which is widely used as a stimulant, carminative, antispasmodic, diuretic, antioxidant and anti-rheumatic.The purpos of thiss research wass to determin the effective of etanol extract of  bagun-bangun seeds (EEDB) on imunostimuensitivity lan hypereduction in male white rats compared with stimuno. Methods: The method used experimental. The sample of in this research was bangun-bangun seeds which were take purposivelyy without comparring samples from the other regiions, thenit is extracted by maceration using 80% ethanol and made in the form of thick extract. The results of the study: Imunostimulan efectivity effects were tested on 25 male rats with 5 treatment groups namely, negative group (CMC Na 1%), positive group (stimuno), EEDB group 100mg/kgBW, EEDB group 200mg/kgBW, and EEDB group 300mg/kgBB. Data analysis use the one way ANOVA method.The resultss of the studyy show thatt the most effectiv treatmentt was simvastatin and among the efective dosage ofEECS was a dose of 300mg/KgBW. The resultss of data analysis from the tthree EEDB groups had an effect on cholesterol reducttion due to the sig value <0.05. Based on anovva one way analysis of the five most effective treatmentss was stimuno then EEDB 300mg/kgBW, EEDB 200mg/kgBW, EEDB 100mg/kgBW and CMC Na 1%.EEDB has an effect on imunostimulan reduction but does not give better results than stimuno. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2021-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/757 10.36656/jpfh.v4i1.757 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 1 (2021): Jurnal Penelitian Farmasi & Herbal; 20-28 2654-7619 10.36656/jpfh.v4i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/757/507 10.36656/jpfh.v4i1.757.g507 Copyright (c) 2021 Anggun Syafitri, Linta Meliala

oai:ojs2.ejournal.delihusada.ac.id:article/759 2021-12-25T12:12:26Z JPFH:FAR driver

ANALISIS FAKTOR YANG BERHUBUNGAN DENGAN KEPATUHAN PEGAWAI INSTALASI FARMASI DENGAN PENGGUNAAN ALAT PELINDUNG DIRI ( APD) DI RSUD KISARAN TAHUN 2021 Sulasmi, Sulasmi Background: PPE is a tool used to protect yourself or the body against the dangers of work accidents. The factors that influence adherence are K3 training, knowledge, behavior, age, gender. The Pharmacy Installation is a part of the hospital that manages the hospital's pharmaceutical needs, medicines, (BMHP), and medical devices. handling and controlling B3 as well as hospital injection drugs which of course have a risk of exposure to hazardous biological substances (biohazard). The purpose of this study was to analyze the factors associated with the compliance of pharmacy installation staff with the use of PPE at Kisaran Regional Hospital in 2021.Methods: This type of research used quantitative research using a cross sectional approach. The number of samples in this study were 30 people. The sample was determined by a simple technique of selecting the sample using purposive sampling. The results of the study: The data was collected using a questionnaire sheet and then processed using a statistical computer program with the chi square test with a significance level of α = 0.05 (95%). The results of the study found that the relationship of compliance with PPE use with age (p = 0.002 <α 0.05), gender (p = 0.127> α 0.05), K3 training (p = 0.004 <α 0.05), Knowledge (p = 0.018 <α 0.05) and Behavior (p = 0.011 <α 0.05). It is recommended for Kisaran Hospital to further improve the Compliance with the Use of PPE, especially for Pharmacy Installation employees. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2021-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/759 10.36656/jpfh.v4i1.759 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 1 (2021): Jurnal Penelitian Farmasi & Herbal; 29-35 2654-7619 10.36656/jpfh.v4i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/759/508 10.36656/jpfh.v4i1.759.g508 Copyright (c) 2021 Sulasmi Sulasmi

oai:ojs2.ejournal.delihusada.ac.id:article/761 2021-12-25T12:12:26Z JPFH:FAR driver

UJI EFEKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN GELUGUR (Garcinia atroviridis Griff ex. T Anderson)TERHADAP TIKUS JANTAN PUTIH (Rattus norvegicus) DENGAN LOPERAMIDE SEBAGAI PEMBANDING Sembiring, Pintata Gelugur leaf (Garcinia atroviridis Griff ex T. Anderson) is a kind of nadir is believed to origanate from the wild forest of Peninsular Malaysia. Gelugur  leaves have antidiarrheal compounds in the shapes of tannins and flavonoids to reduce diarrhea. The purpose of this study was to find out the antidiarrheal activity of the ethanolic extract of gelugur leaf in white male rats. The antidiarrheal effect was tested on 15 white male rats with 5 treatment groups, namely, a negative control group of 1% CMC Na, a positive control group of loperamidee hcl, and a treatment group of ethanol extract of gelugur leaves at a dose of 150 miligrams/kgBW, a dose of 300 miligrams/kgBW, and 600 miligrams/kg body weight. Each group was given oral treatment and observations were made on the onset of diarrhea, frequency of diarrhea, and stool consistency. Tests were carried out using an experimental method. The ethanol extract of gelugur leaves was made by maceration method using 96% ethanol. The results of the study on the onset of diarrhea were EEDG 600 miligrams/kgBB (60 minutes), a good decrease in diarrhea frequency was indicated by EEDG 600 miligrams/kgBB (4 times), a good decrease in stool weight was shown by EEDG 600 miligrams/ kgBB (0,7757 grams), good consistency was also shown in the EEDG 600 miligrams/kgBB (soft stools. The data were statistically analyzed using One Way Anova. The results of data analysis from the three EEDG groups affected the decrease in diarrhea because the sig value <0.05 Based on One Way Anova analysis, the five most effective treatments were loperamidee, 600 miligrams/kgBB, EEDG at 300 miligrams/kgBB, EEDG at 150 miligrams/kgBB, and CMC Na 1%.  The conclusion in this study is that EEDG 600 miligrams/kgBB has antidiarrheal activity induced by oleum recini when compared with EEDG concentrations of 150 miligrams/kgBB and 300 miligrams/kgBB. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2021-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/761 10.36656/jpfh.v4i1.761 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 1 (2021): Jurnal Penelitian Farmasi & Herbal; 36-43 2654-7619 10.36656/jpfh.v4i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/761/509 10.36656/jpfh.v4i1.761.g509 Copyright (c) 2021 Pintata Sembiring

oai:ojs2.ejournal.delihusada.ac.id:article/762 2021-12-25T12:12:26Z JPFH:FAR driver

PERBANDINGAN UJI EFEKTIVITAS ANTIDIABETES TERHADAP LUMATAN DAUN SALAM (Syzygium polyanthum Wight) DAN DAUN UBI JALAR UNGU (Ipomoea batatas L.) PADA MENCIT TAHUN 2021 Sanjaya, Angga Nugraha Barus, Bunga Rimta Background: Agustin, Diana parmaning Comparison of antidiabetic effectiveness tests against crushed bay leaves (Syzygium polyanthum W) and purple sweet potato leaves (Ipomoea batatas L) in mice in 2021. (Supervised by: apt. Bunga Rimta Barus, S.farm.,M.Si ) Diabetes mellitus is a constant metabolic infection portrayed by an expansion in blood glucose levels that can be treated with customary medication got from plants. One illustration of a plant that can decrease blood glucose levels is inlet leaf and purple yam leaf which contain flavonoids to bring down blood glucose by expanding cell affectability to insulin and expanding insulin in pancreatic cells. To decide the impact of the blend of cove leaf concentrate and yam leaf in bringing blood glucose levels contrasted down with glibenclamide. The trial study utilized 15 mice which were initiated by alloxan and partitioned into 5 gatherings. Gathering 1 (negative control) CMC Na 1%, bunch 2 (positive control) glibenclamide at a portion of 0.65 mg/kgBB, bunch 3 a solitary cove leaf remove at a portion of 100 mg/kgBB, bunch 4 a solitary purple yam leaf separate at a portion of 200 mg/kg. kgBB, bunch 5 blend of straight leaf separate at a portion of 150 mg/kgBB and purple yam leaf extricate at a portion of 150 mg/kgBB. Extraction utilizing maceration strategy with 96% ethanol dissolvable. From the aftereffects of the investigation, every treatment bunch encountered a lessening in blood glucose levels. Of the 5 treatment gatherings, the best decrease in blood glucose levels was the three mix gatherings. Among the three mix gatherings, the mix portion of 150 mg/kgBB of inlet leaves and 150 mg/kgBB of purple yam leaves was the best contrasted with glibenclamide in bringing down blood glucose levels.Conclusion: The blend of sound leaf concentrate and purple yam leaf has a more successful impact on bringing down blood glucose levels than glibenclamide and its single concentrate. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2021-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/762 10.36656/jpfh.v4i1.762 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 1 (2021): Jurnal Penelitian Farmasi & Herbal; 44-51 2654-7619 10.36656/jpfh.v4i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/762/510 10.36656/jpfh.v4i1.762.g510 Copyright (c) 2021 Angga Nugraha Sanjaya, Bunga Rimta Barus

oai:ojs2.ejournal.delihusada.ac.id:article/763 2021-12-25T12:12:26Z JPFH:FAR driver

Formulasi Dan Uji Sifat Fisik Gel Hand Sanitizer Ekstrak Etanol Daun Lidah Mertua(Sansevieria Trifasciata Prain) Barus, Bunga Rimta Gel hand sanitizer telah banyak digunakan sebagai salah satu cara untuk menjaga kesehatan dan kebersihan tangan yang praktis dan mudah dibawa. Umumnya gel handsanitizer mengandung senyawa alkohol sebagai antiseptik untuk membunuh bakteri, tetapi penggunaan gel antiseptik yang mengandung alkohol dalam jangka panjang dapat menimbulkan iritasi. Oleh karena itu, diperlukan bahan alternatif alami yang ramah di kulit. dan tidak mengiritasi kulit,.salah satu tanaman yang memiliki daya antibakteri adalah daun lidah mertua (sansevieria trifasciata prain). Tujuan penelitian ini untuk mengetahui formulasi dan uji sifat fisik gel handsanitizer dari ekstrak daun lidah mertua (sansevieria trifasciata prain). Penelitian ini merupakan penelitian eksperimen dengan data hasil penelitian disajikan secara deskriptif. Gel dibuat dalam tiga formula dengan kosentrasi yang berbeda yaitu 10%, 20%, 30%. Evaluasi fisik gel yang dilakukan meliputi uji organoleptik, homogenitas, daya lekat, pH, viskositas, dan hedonik. Hasil evaluasi menunjukan formula 1 (10%) dan formula 2 (20%) dan formula 3 (30%). memenuhi semua syarat pada evaluasi sifat fisik gel yang meliputi uji organoleptik, homogenitas, daya lekat, pH, viskositas, dan hedonik. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2021-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/763 10.36656/jpfh.v4i1.763 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 1 (2021): Jurnal Penelitian Farmasi & Herbal; 52-59 2654-7619 10.36656/jpfh.v4i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/763/511 10.36656/jpfh.v4i1.763.g511 Copyright (c) 2021 Bunga Rimta Barus

oai:ojs2.ejournal.delihusada.ac.id:article/766 2023-04-03T08:31:10Z JPFH:FAR driver

FORMULASI DAN UJI EFEKTIVITAS SEDIAAN GEL DARI EKSTRAK DAUN SUJI (Dracaena agustifolia) PADA TIKUS JANTAN PUTIH SEBAGAI ANTIINFLAMASI Simorangkir, Delisma Marsauli Meliala, Linta Background: Leaf suji (Dracaena angustifolia) is a native plant of Indonesia that is used as a natural food coloring. However, ethnobotany and pharmacologicalreviews reveaed that this plant had potential as amedicinal ingredient one of them is for anti-inflamatory because it contains saponins that can reduce swelling. Methods: The objective of thE study to determine the gel from suji leaf extract works effectively as an anti-inflmatory against the feet of white male rays and to determine at what concentration the gel preparation from suji leaf ekstract is good as an anti-inflamatory. The method of the study used experimental. The results of the study: The gel preparation of suji leaf extract works effectively as an anti- inflamatory because it can inhibit inflamation in the feet of male white wistar rats well and the concentration of carrageenan induction, which is at a concentration of 20%. Keyword : Gel preparation, daun suji, anti-inflamatory Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2021-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/766 10.36656/jpfh.v4i1.766 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 1 (2021): Jurnal Penelitian Farmasi & Herbal; 60-68 2654-7619 10.36656/jpfh.v4i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/766/750 Copyright (c) 2021 Delisma Marsauli Simorangkir, Linta Meliala

oai:ojs2.ejournal.delihusada.ac.id:article/767 2021-12-25T12:12:26Z JPFH:FAR driver

UJI FORMULASI SEDIAAN SALEP EKSTRAK ETANOL DAUN PACAR (Lawsonia inermis L.) TERHADAP BAKTERI Staphylococcus aureus DAN Pseudomonas aeruginosa Harahap, Nina Irmayanti Background: Indonesia is a country rich in natural resources that can be used as traditional medicine. Pacar leaf extract (Lawsonia inermis L.) can be formulated into ointment preparations, can inhibit the growth of staphylococcus aureus (SA) and pseudomonas aeruginosa (PA) bacteria and determine the best inhibitory concentration. Methods: This research method was experimental, the extract was obtained by maceration method with 80% ethanol solvent, then ointment was made using adeps lanae base, vaseline album and Pacar leaf extract ointment hadcombination concentrations 8%, 12% and 16%. The results of the study: The results showed that Pacar Leaf Extract (SEEDP)could be formulated as an ointment preparation and met the requirements for quality testing of ointment preparations, including characterization tests and phytochemical screening tests. The results of the antibacterial activity test showed that the formulation of the ointment preparations of Pacar  Extract with concentrations of 8%, 12% and 16% could inhibit the growth of bacteria and good inhibition of 16% with an average diameter of bacteria (SA). 11.93 mm and bacteria (PA) 17.2 mm.It was concluded that the higher the concentration of the extract, the greater the inhibition given. The preparation of pacar leaf extract ointment with concentrations of 8%, 12% and 16% was the best ointment in inhibiting the growth of bacteria (SA) and (PA)   Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2021-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/767 10.36656/jpfh.v4i1.767 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 1 (2021): Jurnal Penelitian Farmasi & Herbal; 69-74 2654-7619 10.36656/jpfh.v4i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/767/514 https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/767/515 10.36656/jpfh.v4i1.767.g514 10.36656/jpfh.v4i1.767.g515 Copyright (c) 2021 Nina Irmayanti Harahap

oai:ojs2.ejournal.delihusada.ac.id:article/768 2021-12-25T12:12:26Z JPFH:FAR driver

PENETAPAN KADAR STEROID PADA EKSTRAK DAUN TITANUS (Leea aequata L.) SECARA SPEKTROFOTOMETRI UV-VIS Perbina, Dian Ika Purba, Jhan Saberlan The titanus plant (Leea aequata L.) is a plant that used as traditional medicine. The stems and roots are used as astringent, anthelmintic, indigestion, jaundice, chronic fever and malaria. The leaves and twigs are used as an antiseptic and to treat wounds. Steroids are secondary metabolites that have a compound structure that quite diverse. Steroids have a pharmacological effect on lowering cholesterol and anticarcinogenic. The objective of the research to determine the steroid levels in titanus leaf extract (Leea aequata L.). The analytical method used is qualitative with reagents Lieberman-Bouchard and quantitative uv-vis spectrophotometry with wavelength of 423 nm. The results of the qualitative analysis of the positive samples contained steroid compounds. The Results quantitative content of ethanol extract of titanus leaf 30.8889 mg/g, and quantitative results ethyl acetate extract content of titanus leaves 72.2649 mg/g. Validity test results obtained linearity test r=0.9994, RSD of ethanol extract 0,2852% and ethyl acetate extract 8,1120%, recovery of 101% ethanol extract and 103.667% ethyl acetate extract, LOD 2.2078 and LOQ 7,3593. SPSS analysis results p=0.000 (p<0.05). Based on the results of the research that has been done, it can be concluded that uv-vis spectrophotometry can be used to determine total steroid content of titanus leaf extract (Leea aequata L.). Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2021-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/768 10.36656/jpfh.v4i1.768 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 1 (2021): Jurnal Penelitian Farmasi & Herbal; 75-82 2654-7619 10.36656/jpfh.v4i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/768/524 10.36656/jpfh.v4i1.768.g524 Copyright (c) 2021 Dian Ika Perbina, Jhan Saberlan Purba

oai:ojs2.ejournal.delihusada.ac.id:article/847 2022-04-28T11:04:56Z JPFH:FAR driver

Uji Efektivitas Antidiabetes Kombinasi Ekstrak Buah Pare (Momordica charantia L.) Dan Kelopak Bunga Rosella (Hibiscus sabdariffa L.) Pada Tikus Jantan Putih Sebagai Hewan Percobaan Syafitri, Anggun Diabetes mellitus is a chronic metabolic disease characterized by an increase in blood glucose levels which can be treated with traditional treatments derived from plants. One of the example is a plant that can reduce blood glucose levels are bitter melon and rosella which contain flavonoids to reduce blood glucose by increasing cell sensitivity to insulin and stimulating insulin release in pancreatic β cells. The objective of the research is to determine the effect of the combination of bitter melon extract and rosella petal extract in reducing blood glucose levels compared to glibenclamide. The method of the research is an experimental study used 21 rats induced by alloxan and divided into 7 groups. Extraction using maceration method with 80% ethanol. From the results of the study, each treatment group experienced a decrease in blood glucose levels. From the 7 treatment groups, the best reduction in blood glucose levels were the third combination group. Among the three combination groups, the combination dose of 225 mg/kgBB of bitter melon and 195 mg/kgBB of rosella flower petals was the best compared to glibenclamide in reducing blood glucose levels. The conclusion of the research is combination of bitter melon extract and rosella flower petals have an effect that are more effective in reducing blood glucose levels compared to glibenclamide and their single extract. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/847 10.36656/jpfh.v4i2.847 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 2 (2022): Jurnal Penelitian Farmasi & Herbal; 1-8 2654-7619 10.36656/jpfh.v4i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/847/568 Copyright (c) 2022 Anggun Syafitri

oai:ojs2.ejournal.delihusada.ac.id:article/852 2022-04-28T11:04:56Z JPFH:FAR driver

ANALISIS SALAH SATU OBAT HERBAL DI SUMATERA UTARA TAHUN 2021 Tambusai, Christivo Nerdy, Nerdy Fahdi, Firdaus The existence of competition between chemical and traditional drugs has resulted in increasingly being displaced from the market. In addition, another problem that traditional medicine has not been widely used for both self-medication and formal health services is that most of the efficacy of traditional medicine has not been scientifically tested. Therefore, it is very important to do an analysis through research. The purpose of this study was to determine the efficacy of traditional medicine PT. Amanah Berkah Kencana in improving health and body immunity. The research method used in this study is a descriptive method with a cross- sectional  approach.  The  main  informants  in  this  study  were  consumers  of traditional medicine PT. Amanah Berkah Kencana. This research was conducted in North Sumatra from December 2021 to February 2022. The results of the study explain that 82.5% strongly agree. The results of this percentage show a very good picture for consumers who use Haseda traditional medicine in maintaining health and increasing human immunity. The remaining 17.5% do not agree because of lack of public education and knowledge about the use and benefits of traditional medicine for health. For health observers, there should be socialization to the public about the use of traditional medicines. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/852 10.36656/jpfh.v4i2.852 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 2 (2022): Jurnal Penelitian Farmasi & Herbal; 9-19 2654-7619 10.36656/jpfh.v4i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/852/569 Copyright (c) 2022 Christivo Tambusai, Nerdy Nerdy, Firdaus Fahdi

oai:ojs2.ejournal.delihusada.ac.id:article/853 2022-04-28T11:04:56Z JPFH:FAR driver

FORMULASI DAN UJI EKTIVITAS ANTIBAKTERI SEDIAAN LOTION EKSTRAK ETANOL DAUN SAWAO TERHADAP BAKTERI Stapylococcuc aureus dan Escherchia coli Sembiring, Pintata Manila sapodilla leaves contain phytochemical mixtures of alkaloids, flavonoids, saponins, tannins, terpenoids and glycosides which are known to have antibacterial movement of Staphylococcus aureus and Escherichia coli. The reason for this study was whether the planning of sapodilla leaf extricate salve can be utilized as an enemy of bacterial technique. This exploration was led utilizing a trial which plans to decide all side effects or impacts that emerge, because of specific medicines. Sawo Leaf Ethanol Extract was completed by submerging maceration utilizing 96% ethanol. Antibacterial action testing was done on Sawo leaf extricate with different centralizations of 5%, 10% and 20% and Chaladine cream as a positive control was completed utilizing the discdiffusion strategy. The consequences of the restraint zone movement of Staphylococcus aureus antibacterial lotio arrangements Chaladine sapodilla leaf remove 18 mm, Extract focus 5% 14.5 mm, Extract fixation 10% 20.3 mm, Extract focus 20% 15.46 mm, The aftereffects of the inhibitory zone action in the cream readiness antibacterial concentrate of sapodilla lotio leaf Escherichia coli lotio Chaladine 14 mm, Extract focus 5% 14.16 mm, Extract fixation 10% 20.3 mm, Extract fixation 20% 16.06 mm > 0.05, this demonstrates that the information are typically dispersed, homogeneity trial of 2 gatherings of microscopic organisms and shows a meaning of p > 0.05, showing that the information utilized came from homogeneous information. This demonstrates that Lotio ethanol concentrate of sapodilla leaves has antibacterial movement. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/853 10.36656/jpfh.v4i2.853 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 2 (2022): Jurnal Penelitian Farmasi & Herbal; 20-28 2654-7619 10.36656/jpfh.v4i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/853/570 Copyright (c) 2022 Pintata Sembiring

oai:ojs2.ejournal.delihusada.ac.id:article/854 2022-04-28T11:04:56Z JPFH:FAR driver

UJI EFEKTIVITAS SALEP EKSTRAK ETANOL DAUN BUNGA KERTAS (BOUGAINVILLEA GLABRA) TERHADAP LUKA EKSISI PADA TIKUS JANTAN PEMBANDING POVIDONE IODINE SALEP Simorangkir, Delisma The wound is a physical injury that results in tears and damage to skin tissue. One type of wound is excision wound, excision wound is of the a wound that is caused by cutting tissue by sharp object scratches. The main goal in wound management is to achieve rapid healing with optimal function and good results. That can be achieved by preventing further infection and trauma with the availability of an environment that can optimize the healing of the wound. One plant that has the potential to heal wounds is the paper petal plant. The purpose of thes study is to find out the effectiveness of giving paper petal extract to the healing of excision wounds in male rats. The study conducted in the Laboratory Health Institute of the Deli Husada Deli Tua. The extracts formulated into ointment preparations with concentrations of 10%, 15%, and 20% then conducted evaluation of ointment preparations, namely organoleptic tests, homogeneity tests, ph tests, visicosity tests, hedonic tests and spread power tests. The results of organoleptic tests and irritant tests of paper petal ethanol extract ointment preparations, all concentrations were declared good while in the most preferred hedonic test was a concentration of 10%. From the results of the spread test is a concentration of 15% with a static test value on the 21st day which is 6.3000 where this value is equal to the value of povidone iodine, while in the pH test on the 21st day the concentration that sees the best statistic test value is 10% concentration with a value of 6.4467 which is close to the value of povidone iodine which is 7.3133. The results of the study is each treatment group experienced a decrease in the diameter of the cut wound. Of the 5 treatment groups, the best reduction in the diameter of the cut wound was the positive control group (povidone iodine) and the 20% concentration where the statistic test value on the 15th day was 0.0000 where this value was equal to the value of povidone iodine.   Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/854 10.36656/jpfh.v4i2.854 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 2 (2022): Jurnal Penelitian Farmasi & Herbal; 29-35 2654-7619 10.36656/jpfh.v4i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/854/571 Copyright (c) 2022 Delisma Simorangkir

oai:ojs2.ejournal.delihusada.ac.id:article/855 2022-10-31T06:43:12Z JPFH:FAR driver

UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL HAND SANITIZER SANITIZER BUNGA LAWANG (Illiacium verum Hook. f) pada BAKTERI Staphylococcus aureus & Escherichia coli Marbun, Novarianti Abstract Some diseases caused by microorganisms on the hands are diarrhea, diphteria, boils, typhus and others. The bacteria that most often contaminate the skin of the hands are Staphylococcus aureus and Escheria coli, whose spreas most often transmitted from hand to hand. Bunga lawing are one of the medicinal plants that have been used in medicine. The purpose of this study was determine the antibacterial activity of gel hand essential oil sanitizer gel preparation (Illiacium verum Hook.f) to the growth of Staphylococcus aureus and Escheria coli bacteria compared to sanitizer Dettol gel hand. This was carried out with the experimental method. Essential oil of bunga lawing is extracted using a heat method, namely soxhletation. The antibacterial activity test in this study used the agar diffusion method (disc diffusion). The measurement of the diameter of the inhibited area formed were analyzed using a one-way ANOVA statistical test. The results of antibacterial activity of bunga lawang sanitizer hand have lower antibacterial activity gel hand sanitizer Dettol. In the diameter of Staphylococcus aureus bacteria the highest rate 0f hand flower sanitizer gel was 15,1 mm while the sanitizer gel hand wash 21,4 mm. In Escheria coli bacteria, the inhibitory diameter the sanitizer hand gel dettol was obtained at 20.1 mm, while the lawang handsanitizer gel obtained the highest inhibition diameter of 13.1 mm. The results of data analysis using a one-way ANOVA statistical test showed a sig value p<0,05 so that there were significant differences between the gel hand to the inhibitory power of the growth of Staphylococcus aureus and Escheria coli bacteria.   Keywords: Bunga lawang, hand sanitizer gel, Staphylococcus aureus, Escherichia coli Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/855 10.36656/jpfh.v5i1.855 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 1-4 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/855/646 Copyright (c) 2022 Novarianti Marbun

oai:ojs2.ejournal.delihusada.ac.id:article/856 2022-04-28T11:04:56Z JPFH:FAR driver

FORMULASI DAN UJI AKTIVITAS ANTI BAKTERI SEDIAAN SALEP EKSTRAK ETANOL DAUN SIRIH CINA (peperomia pellucida) TERHADAP BAKTERI Staphylococcus Aureus Sari, Rika Puspita Chinese betel leaf (Peperomiapellucida) is one among the wild herbaceous plants belonging to the Piperaceae family which is employed as a natural medicine. The study's goal was to determine the antibacterial activity of an ethanol extract of Chinese betel leaf ointment against Staphylococcus aureus, as well as the optimal concentration. The test of the study was administered by the diffusion method using disc paper. The results of the characterization examination of Chinese betel leaf simplicia powder obtained water soluble extract content of 64.58%, ethanol soluble extract content of 24.95%, total ash content of three 3.2%, 5.9 % water of content and 0.28% acid insoluble ash content of and Simplisia contains alkaloids, flavonoids, tannins, and saponins. Staphylococcus aureus obtained a degree of 8% with a diameter of 16.81, the diameter of the inhibition zone of the Chinese betel leaf ethanol extract against. The ethanol extract of Chinese betel leaf exhibits antibacterial action against Staphylococcus aureus, according to the findings of the study. Keywords: Antibacterial activity, Chinese betel leaf Staphylococcus aureus Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/856 10.36656/jpfh.v4i2.856 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 2 (2022): Jurnal Penelitian Farmasi & Herbal; 36-44 2654-7619 10.36656/jpfh.v4i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/856/572 Copyright (c) 2022 Rika Puspita Sari

oai:ojs2.ejournal.delihusada.ac.id:article/858 2022-10-31T06:43:12Z JPFH:FAR driver

UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL RUMPUT MUTIARA (Hedyotis corymbosa L. Lamk) TERHADAP TIKUS PUTIH Ardiani, Rani Inflamation is the body’s defense mechanism in response to tissue injury and interference by external factors. Pearl grass (Hedyotis Corymbosa L.Lamk) is one of  Rubiaceae family. Pearl grass have efficacy in the treatment as anti-inflamatory, anti-diabetic, anti-bacteria, and antioxidant. Pearl grass contains flavonoids has pharmacological effects as a anti-inflamatory. The purpose of this study was to determine the anti-inflamatory effect of ethanolic extract of pearl grass (EERM) on white rats incuded by λ- carragenan.This research was conducted by experimental method which included pearl grass extraction, phytochemical screening, and anti-inflamatory activity test of ethanolic of pearl gras with paw edema method using digital plethysmometer. As experimental animals 15 rats were divided into 5 groups, each group were 3 rats. As an inductor λ-carragenan 1 % was administered intraplantar. Sodium carboxy methyl cellulose (Na-CMC) 0,5 % as negative control, 2,25 mg/kg bw diclofenac dose as positif control and ethanolic extract of pearl grass dose 100 mg/kg bw, dose 200 mg/kg bw, and dose of 400 mg/kg bw as a test material given orally. Observations were made for 6 hours. The test data were analyzed statistically using one way ANOVA and continuced with Tukey’s B.The results of phytochemical indicated that ethanolic extract of pearl grass contained alkaloids, flavanoid, saponins, tanin and glycosides. The dosage of ethanolic extract of pearl grass 100 mg/kg bw, dose 200 mg/kg bw, dose 400 mg/kg bw has the effect as anti-inflamatory. The effective dose of ethanol extract of pearl grass as an anti-inflamatory in white rats was 400 mg/kg bw. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/858 10.36656/jpfh.v5i1.858 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 5-9 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/858/647 Copyright (c) 2022 Rani Ardiani

oai:ojs2.ejournal.delihusada.ac.id:article/860 2022-04-28T11:04:56Z JPFH:FAR driver

The FORMULATION AND EVALUATION O FORMULATION AND EVALUATION OF THE PREPARATION OF HAIR TONIC Ethanol Extract of Patchouli Leaves (Pogostemon cablin Benth.) TO OVERCOME HAIR LOSS Barus, Bunga Rimta Meliala, Linta Nilam leaves contain flavonoids. flavonoids that have activity that can accelerate hair growth and prevent hair loss. The purpose of the study was to make a hair tonic preparation containing patchouli leaf extract and to determine the concentration of the best formula to treat hair loss. Hair tonic is made with nilam  leaf extract at concentrations of 5%, 10%, 15%. The ingredients for making Hair Tonic include propylene glycol, propyl paraben, methyl paraben, menthol, sodium metabisulfite, 96% ethanol, Ol. Rosae, Aquades. The method of the study an experimental method with extraction by maceration for 5 days and remaceration for 2 days using 96% ethanol as solvent. Evaluation of Hair Tonic preparations includes homogeneity, pH, organoleptic, viscosity, irritation, preference, and hair growth effectiveness test. The effectiveness test on hair growth in rabbits was carried out on 5 rabbits with 5 treatment groups, namely, positive control group Hair Tonic nature, negative control group, 5% concentration group, 10% concentration group, and 15% concentration group. The analysis of the data on growth testing using One Way Anova. Hair growth data on day 12 were positive control 0.95 mm, negative control 0.03 mm, formula 1 (5%) 0.08 mm, formula 2 (10%) 0.13 mm, formula 3 (15%) 0.83mm. The best formula to treat hair loss is hair tonic with a concentration of 15% nilam leaf ethanol extract. It can be concluded that the greater the concentration of nilam leaf extract given to each treatment, the faster the hair growth. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/860 10.36656/jpfh.v4i2.860 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 2 (2022): Jurnal Penelitian Farmasi & Herbal; 45-51 2654-7619 10.36656/jpfh.v4i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/860/573 Copyright (c) 2022 Bunga Rimta Barus, Linta Meliala

oai:ojs2.ejournal.delihusada.ac.id:article/861 2022-04-28T11:04:56Z JPFH:FAR driver

FORMULASI SEDIAAN BLUSH ON DARI EKSTRAK KUBIS UNGU (Brassica Oleracea L. var. capitates f. rubra) SEBAGAI PEWARNA DALAM BENTUK COMPACT POWDER Nadia, Nadia Cosmetics have been known to humans since centuries ago. Since the last 40 years, cosmetics has grown rapidly. Quantias and the quality of biological materials for use on the skin are increasing. Blush on is created from attractive colors and of course using coloring agents. Purple cabbage extract is used as a dye in blush on with a concentration of 30% and Isopropyl myristate as a binder with various concentrations of 0.5%, 1.0% and 2.0%. Purple cabbage extract was obtained by 96% ethanol maceration, then filtered and rotary using a rotary evaporator, then evaporated in a water bath with a temperature of 700 C. Blush on is made by pressing. The extract yield obtained was 18.68%. The observations show that preparations with a concentration of Isopropyl myristate 1.0% are better and more preferable because the preparation is not brittle and not too hard. In the pH test, all dosages meet the requirements. In the irritation test, all preparations did not cause irritation reactions to all panelists. Purple cabbage extract can be used as a natural dye in the process of making blush on and the best concentration of Isopropyl myristate is 1.0%. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/861 10.36656/jpfh.v4i2.861 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 2 (2022): Jurnal Penelitian Farmasi & Herbal; 52-56 2654-7619 10.36656/jpfh.v4i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/861/576 Copyright (c) 2022 Nadia Nadia

oai:ojs2.ejournal.delihusada.ac.id:article/862 2022-04-28T11:04:56Z JPFH:FAR driver

FORMULASI SEDIAAN MASKER Gel Peel Off EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium Guajava L.) SEBAGAI PEMBERSIH WAJAH Tarigan, Palas Guava plants contain psiditanin “eugenol” essential oil, tannis, flavonoids, saponins, alkaloids. Compounds that have very good strength come from the class of flavanoids, vitamin C which can be usedas a facial cleanser. This study aims to determine the preparation of peel gel mask of guava leaf extract is effective as a facial cleanser and to find out the peel off gel mask of guava leaf extract can irritate the skin of volunteers. The made with 4 formulation with concentrations of 0%, 10%, 15%, 20%. The testing of the peel off gel mask formulation ethanol extract on cleanliness was carried out with the analysis of the ms. Excel bar diagram. The results showed that (psidium guajava L) contain flavonoid, alkaloids, tannins and saponins. The results of the characteristics of the simplicia powder were 5,42% water content 9,56% total ash content 0,34% acid insoluble ash, ethanol soluble extract 64,295. The results of the peel off gel mask formulation test with a cleanliness test on the panelists facial skin concentration of 15% included in the category can clean the panelist’s facial skin.Guava leaf ethanol extract has a facial cleansing activitywith a score of 3   Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/862 10.36656/jpfh.v4i2.862 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 2 (2022): Jurnal Penelitian Farmasi & Herbal; 57-62 2654-7619 10.36656/jpfh.v4i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/862/575 Copyright (c) 2022 Palas Tarigan

oai:ojs2.ejournal.delihusada.ac.id:article/865 2022-04-28T11:04:56Z JPFH:FAR driver

UJI AKTIVITAS EKSTRAK BUAH ARA (Ficus carica Linn) TERHADAP TIKUS YANG DI INDUKSI ALOKSAN Suri, Atika Patni Diabetes is a disease in which the blood sugar level rises above the normal level. When blood sugar levels are regulated by the hormone insulin produced by the pancreas. The fig fruit (Ficus carica Linn) is a plant that is thought to be used as an herbal remedy in the management of diabetes. Contains flavonoids which are thought to have potential as antidiabetic. Flavonoid mechanism in reducing blood glucose levels is to reduce glucose absorption and increase insulin secretion. Flavonoids are phenol compounds that have several pharmacological activities. Objective knowing antidiabetic activity of fig extract (Ficus carica Linn) against mice induced by alloxan. The process used is a 70% ethanol solvent immersion process. This study method is designed before and after the control group. Fifteen rats were divided into 5 treatment groups. 1 (negative control) received the CMC Na 1% group, 2 (positive control) received glibenclamide 0.09 mg / kgBB, 3, 4 and 5 received 9 mg / kgBB, 18 mg / kgBB, and 36 mg / kg. The fig extract was administered at a dose of kgBB. Previously, rats were given alloxan 125 mg / kg BB intraperitoneally for 3 days and mice with a blood glucose level of ± 200 mg / dL were used in this study. The results of this study showed that glibenclamide 0,09 mg/kgBB and fig extract dose 36 mg/kgBB could reduce the best glucose levels for seven days. Conclusion the best glibenclamid as antidiabetic in male white rats induced by alloxan and fig extract at a dose of 36 mg/kgBB 1,5% concentration is good as antidiabetic mellitus in male white mice induced by alloxan. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/865 10.36656/jpfh.v4i2.865 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 2 (2022): Jurnal Penelitian Farmasi & Herbal; 63-68 2654-7619 10.36656/jpfh.v4i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/865/577 Copyright (c) 2022 Atika Patni Suri

oai:ojs2.ejournal.delihusada.ac.id:article/866 2022-04-28T11:04:56Z JPFH:FAR driver

PEMBUATAN MIKROKRISTALIN SELULOSA (MCC) dari BATANG PISANG MAS (Musa acuminata colla) dengan AVICEL PH 102 SEBAGAI PEMBANDING TAHUN 2019 Erdiwan, Erdiwan Commercial cellulose microcrystalline known as Avicel PH 102, which is a tablet filling material Avicel PH 102 which is expensive and uses a lot of it, it is necessary to look for other alternative sources of producing microcrystalline cellulose. The Waste of banana stem contains water content of 80-90%, cellulose 63-64%, hemicellulose 20%, and lignin 5% and contains 11-12% other constituens so that it can be the basic material for making MCC. This study aimed to isolate α-cellulose from banana mas stems and characterize microcrystalline cellulose with Avicel PH 102. The method of this study was an experimental. Microcrystalline banana stem cellulose is obtained by heating banana stem powder with 4% NaOH which serves to dissolve lignin, then bleached with 2.5% NaOCl, 17.5%  NaOH heated to dissolve β-cellulose and γ-cellulose, and heated with HCL 2 N . The results are hydrolyzed with α-cellulose and then hydrolyzed with 2.5N HCl to give microcrystalline cellulose, which is characterized and compared to Avicel PH102. The result of characterization of banana mas stem microcrystalline cellulose and Avicel PH 102 which were obtained respectively is organoleptic tests of coarse powder, white, doesn’t have any smells; pH 6.6 and 6.5; solubility of substances in water 0.023 and 0.023%; total ash content are 0.17 and 0.12%; decrease of drying 5.47 and 5.28%; real density 0.337 and 0.404 g / cm3; true type weight 1.43 and 1.43 g / cm3; incompressible density 0.478 and 0.480 g / cm3; compressibility index 41.77 and 18.85%; Hausner index 1.41 and 1.18; porosity; 76.43 and 93.640%. Based on the results of the study concluded that microcrystalline cellulose can be made from banana mas stems and has the same characteristics as Avicel PH 102. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/866 10.36656/jpfh.v4i2.866 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 2 (2022): Jurnal Penelitian Farmasi & Herbal; 64-70 2654-7619 10.36656/jpfh.v4i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/866/578 Copyright (c) 2022 Erdiwan Erdiwan

oai:ojs2.ejournal.delihusada.ac.id:article/867 2022-04-28T11:04:56Z JPFH:FAR driver

Pengaruh Pemberian Omeprazole Terhadap Profil Farmakokinetika Piroxicam Dengan Metode Kromatografi Cair Kinerja Tinggi (KCKT) Sipayung, Dasma Arihan Nauli Piroxicam is an anti-inflammatory drug belonging to the NSAID group and is also used as an analgesic and anti-rheumatic drug. Its use is often combined with stomach medicines, as the side effects of piroxicam can irritate the stomach. One of them is omeprazole. Since piroxicam and omeprazole act on the same enzyme, CYP450, they can affect the pharmacokinetic profile, especially at the metabolic stage and excretion of piroxicam. The purpose of this study was to determine the effect of omeprazole on the pharmacokinetic profile of piroxicam especially in the metabolic phase and excretion. The method used in this study was an experimental method using three male rabbits. These rabbits are divided into three groups. The first treatment group was giving pyroxicam solution 0.653 mg / kg body weight, the second treatment group gave piroxicam 0.653 mg / kg body weight that one hour before was given omeprazole 1.2 mg / kg body weight and the third group treated with piroxicam 0.7 mg / kg body weight at the same time with omeprazole 1,4 mg / kg body weight. Plasma levels of the drug piroxicam are measured using a high performance liquid chromatography (HPLC) tool. The verification method is executed. This is the determination of LOD and LOQ values, accuracy and accuracy testing. The result of data analysis using t-table. The results showed that there was an increase or difference in pharmacokinetic parameter values ​​during the absorption phase, but no significant effect was shown for each group. Pharmacokinetic parameter values ​​for metabolic stages and excretion were reduced and no significant difference was shown between the groups. Simultaneous administration of omeprazole and piroxicam and administration of piroxicam 1 hour before omeprazole may inhibit piroxicam-metabolizing enzymes and thus affect pharmacokinetic parameters and excretion during absorption, but are not significant.   Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/867 10.36656/jpfh.v4i2.867 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 2 (2022): Jurnal Penelitian Farmasi & Herbal; 71-78 2654-7619 10.36656/jpfh.v4i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/867/579 Copyright (c) 2022 Dasma Arihan Nauli Sipayung

oai:ojs2.ejournal.delihusada.ac.id:article/868 2022-04-28T11:04:56Z JPFH:FAR driver

PENGUJIAN EFEKTIVITAS PENYEMBUHAN LUKA BAKAR GEL EKSTRAK ETANOL DAUN TEMBAKAU (Nicotiana tabacum L.) PADA TIKUS Hutagalung, Mona Tobacco leaves (Nicotiana tabacum L.) have secondary metabolites namely alkaloids as antibacterial, flavonoids and steroids / terpenoids as antimicrobials and adstringers which play a role in wound shrinkage, efficacious saponins stimulate collagen formation. This study aims to determine the effectiveness of tobacco leaf gel ethanol extract in the healing of burns. Tobacco leaf extract was prepared using a 96% ethanol immersion process. This study of tobacco leaf extract is prescribed in the form of gels at 5%, 10%, and 15% concentrations. There were five groups in this study. The first group (positive control), the second group (negative control), and the third group are tobacco leaf ethanol extract gels 5%, 10%, and 15%. In this study, 15 rats with burns on the backs of mice coated with the test preparation will be measured and photographed once daily. This is done until the wound is 0 cm in diameter or covered with new tissue. The data results of the mean wound healing rate data were statistically tested using the SPSS program. We analyzed the data using Oneway, ANOVA, TukeysB, and LSD to see the actual differences between the processes. The data results of the analysis on day 16 showed that the 15% tobacco leaf ethanol extract had a wound healing effect that was not significantly different from the positive control (Bioplasenton) (p> 0.05). cure burns that are comparable to comparable drugs (Bioplasenton). The conclusion of this study is that the most effective gel concentration is 15% with the day of recovery on the 16th day. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/868 10.36656/jpfh.v4i2.868 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 2 (2022): Jurnal Penelitian Farmasi & Herbal; 79-86 2654-7619 10.36656/jpfh.v4i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/868/581 Copyright (c) 2022 Mona Hutagalung

oai:ojs2.ejournal.delihusada.ac.id:article/869 2022-04-28T11:04:56Z JPFH:FAR driver

Formulasi Dan Evaluasi Sediaan Krim Pewarna Rambut Dari Ekstrak Etanol Umbi Bit (Beta vulgaris L.) Damayanti, Sarah The use of natural hair dyes is a solution to the problem of synthetic hair dyes. one of the plants such as beetroot contains a lot of secondary metabolites, one of which is flavonoids which  can provide specific dyes. The natural color found in beetroot can be used as a natural dye in cosmetics. To find out at what concentration the beetroot produces the most optimal quality physical color of the hair dye preparation. This research method was carried out including making beetroot (Beta vulgaris L.) ethanol extract by maceration for 5 days with 95% ethanol solvent and continued remeseration with the same solvent. The extract formula used was 10%, 15%, and 20% physical evaluation carried out included organoleptic test, irritation test, pH test, homogeneity test, stability test for washing, stability test for sunlight. As a result of inspection of the three hair dye cream formulations, the formulations met the requirements of the test formulations. The results of the hair tack test showed that it gave a good color at a density of 20% time. In the color stability test of the wash after 15 shampoo washes, all three formulations have a fixed color up to 9 washes. Also, in terms of color stability to sunlight, after exposure to direct sunlight, the color appears to change slightly, making the hair darker than before. The result of the concentration of beetroot ethanol extract that gives the best color is a concentration of 20%. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/869 10.36656/jpfh.v4i2.869 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 2 (2022): Jurnal Penelitian Farmasi & Herbal; 87-91 2654-7619 10.36656/jpfh.v4i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/869/582 Copyright (c) 2022 Sarah Damayanti

oai:ojs2.ejournal.delihusada.ac.id:article/870 2022-04-28T11:04:56Z JPFH:FAR driver

FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN LOTION EKSTRAK ETANOL DAUN DUKU (Lansium domesticum Corr.) TERHADAP BAKTERI Staphylococcus Aureus PADA PENYEMBUHAN PENYAKIT KULIT BERNANAH TAHUN 2022 sulasmi, sulasmi Duku leaves (Lansium domesticum Corr.) can be used as an alternative treatment for skin-related diseases such as boils caused by Stapylococcus aureus. Duku leaves contain flavonoids, saponins and triterpenoids that are able to provide antibacterial effects. This study aims to formulate duku leaf extract intopreparations lotion antibacterialagainst Stapylococcus aureus. The study was conducted experimentally, the sample was extracted by maceration method, then the extract was formulated intopreparations lotion with concentrations of 4%, 8% and 12%, of the three concentrations compared with positive control (caladin), negative control (basis lotion), then evaluation was carried out in the form organoleptic test, homogeneity test, dispersion test, pH test, irritation test and hedonic test for each formulation. After the evaluation data was obtained, an antibacterial test was carried out for each formulation. Then proceed with statistical analysis  method One Way Anova. The results obtained at a concentration of 4% have the best formula in terms of organoleptic and hedonic (attractive color), thick shape, smells of perfume). In terms of pH it has a pH of 7.0; spreadability (6.27 cm ± 0.4); There is no irritation in this formulation. Based on statistical analysis, the sig Anova value of P < 0.05 (0.000) showed that there was a difference between each formulation in the concentration variation when compared to the positive control. Based on the antibacterial test the formulation concentration of 12% had the best antibacterial properties, namely 16.82 mm ± 4.00 compared to other formulations and the positive control had the best antibacterial properties, namely 17.32 mm ± 1.58. Based on statistical analysis, sig P value < 0.05 (0.000) which means that there are differences in each antibacterial formulation when compared with positive controls. The results showed that in terms of formulation, lotion with a concentration of 4% was the best formulation compared to other formulas. Based on antibacterial lotion concentration of 12% has the best antibacterial properties compared to other formulas. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/870 10.36656/jpfh.v4i2.870 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 2 (2022): Jurnal Penelitian Farmasi & Herbal; 92-101 2654-7619 10.36656/jpfh.v4i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/870/583 Copyright (c) 2022 sulasmi sulasmi

oai:ojs2.ejournal.delihusada.ac.id:article/871 2022-04-28T11:04:56Z JPFH:FAR driver

BUAH MENGKUDU (Morinda citrifolia), KANDUNGAN DAN EFEKTIVITASNYA SEBAGAI ANTIHIPERTENSI: LITERATURE REVIEW Wahyudi, Wahyudi Background: Hypertension is one of a disease high prevalence in the world today, often called the silent killer because it generally does not cause symptoms in sufferers. This disease is characterized by increased contraction of blood vessels which increases blood pressure against the walls of blood vessels. Mengkudu (Morinda citrifolia) is one of the most widely grown plants in Indonesia which has effective antihypertensive properties. Previous studies have shown that mengkudu can lower blood pressure significantly compared to negative controls. The purpose of writing this article is to make a literature review that comprehensively discusses the effectiveness of mengkudu as an antihypertensive from previous studies that have been carried out. Methods: The writing of this article uses the literature review method on research articles found in the Google Scholar and Science Direct database using the keywords mengkudu, Morinda Citrifolia, hypertension and blood pressure. The criteria for the selected articles are articles published between 2000-2022 in both national and international journals. Literature review was conducted by comparing research methods, processing methods and the results obtained from each article. Results: The results of previous studies showed that  mengkudu had a significant effect on reducing blood pressure. The decrease in blood pressure is related to the content of prexeronin (endothelial vasoactive), scopoletin (causing vasodilation) and xeronine (diuretic effect) contained in mengkudu which can lower blood pressure by different mechanisms. Conlusion: The content of mengkudu has the potential as an antihypertensive because it can significantly lower blood pressure. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/871 10.36656/jpfh.v4i2.871 Jurnal Penelitian Farmasi Dan Herbal; Vol 4 No 2 (2022): Jurnal Penelitian Farmasi & Herbal; 102-108 2654-7619 10.36656/jpfh.v4i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/871/584 Copyright (c) 2022 Wahyudi Wahyudi

oai:ojs2.ejournal.delihusada.ac.id:article/936 2022-10-31T06:43:12Z JPFH:FAR driver

Uji Aktivitas Antibakteri Ekstrak Etanol Daun Rambutan (Nephelium lappaceum L) Pada Pertumbuhan Bakteri Staphylococcus aureus dan Escherichia coli Harahap, Nina Irmayanti The purpose of this study was to determine that the ethanolic extract of rambutan leaves (Nephelium lappaceum L) has antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria. As an antibacterial comparator used Amoxicillin. Each leaf of sample was extracted with maceration methode using 70% of ethanol solvent. Where it 2 to 3 days with several stirring times then it filtered, then the filtrate result was thickened with vacuum rotary evaporator. The antibacterial activity test used the paper disc diffusion method and was observed based on the diameter of the inhibition zone or the clear zone formed around the paper discs and slots which used with three times treatments. Result test of antibacterial activity of rambutan leaf ethanol extract (Nephelium lappaceum L) with these method showed that the extract actively inhibited the growth of Staphylococcus aureus bacteria with Minimum Inhibitory Concentration (MIC)3.125% with a 7.96 mm, but not showed for the growth of Escherichia coli bacteria. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/936 10.36656/jpfh.v5i1.936 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 10-17 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/936/648 Copyright (c) 2022 Nina Irmayanti Harahap

oai:ojs2.ejournal.delihusada.ac.id:article/939 2022-10-31T06:43:12Z JPFH:FAR driver

FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL HAND SANITIZER EKSTRAK ETANOL DAUN BAYAM MERAH (Amaranthus Tricolor L.) TERHADAP BAKTERI Staphylococcus aureus & Eschericia coli Harnis, Zola Efa Red spinach has function as skin antiseptic. It has antibacterial activity because it contains compounds such as tannins, flavonoids, saponins, and steroids. The purpose of formulation and test of antibacterial activity of hand sanitizer gel preparation red spinach extract and evaluation of physical quality of hand sanitizer. Antibacterial activity test was measured by diffusion method using paper disk to measuring the diameter of the bacterial growth inhibition zone of Escherichia coli and Staphylococcus aureus. Concentration extract ethanol of leaf red spinach (and formula of hand sanitizer gel used (F1) blanco; (F2) 5%; (F3) 10%; (F4) 20% and (F5) control positive/detol. Evaluation of physical properties of hand sanitizer gel include of: homogeneity test, stability test and pH test. The results has found showed that antibacterial activity test of gel extract leaves red spinach (on Escherichia coli inhibited at without extract/blanco was 0 mm, concentration of 5% with diameter of inhibit was 14,99 mm, concentration of 10% with diameter of inhibit was 17,26 mm, concentration of 20% with diameter of inhibit was 18,26 mm and using control positive was 19.33. And then for bacteri Staphylococcus aures at concentration of without extract/blanco was 0 mm, 5% with diameter of inhibit was 15,5 mm, concentration of 10% with diameter of inhibit was 15,96 mm and concentration of 20% with diameter of inhibit was 17,43 mm and using control positive was 18.33 mm. So we can conclude that hand sanitizer gel of leaf red spinach have less inhibited growth against  Escherichia coli and Staphylococcus aureus. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/939 10.36656/jpfh.v5i1.939 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 18-25 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/939/649 Copyright (c) 2022 Zola Efa Harnis

oai:ojs2.ejournal.delihusada.ac.id:article/969 2022-10-31T06:43:12Z JPFH:FAR driver

Antioxidant Test of Red and Green Colored-Leaves Infusions of Pucuk Merah (Syzygium myrtifolium Walp.) with DPPH method Wenas, Desy Muliana Meilani, Putrisa Anggun Herdini, Herdini Red and green leaves of the pucuk merah (Syzygium myrtifolium Walp.) contain flavonoids, saponins, and tannins which have the potential as antioxidants. The purpose is test out the antioxidant activity of red leaves and green leaves infusions of red shoots (S. myrtifolium). Test material is extracted using infusion method. The testing of antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The free radical concentration of DPPH was analyzed using UV-Vis spectrophotometer after addition of various concentrations of S. myrtifolium leaves infusion extracts. Various concentrations of S. myrtafolium leaves infusion extracts used were 20 ppm; 10 ppm; 5 ppm; 2.5 ppm; 1.25 ppm; 0.625 ppm. Vitamin C solutions as the positive control were prepared on 5; 2.5; 1.25; 0,625; 0.3125 ppm. The result of the experiment showed the thick red and green leaf extract has IC50 value of 11,130 ppm and 10,522 ppm. The antioxidant activity of green leaf extract is higher than the red leaf extract. Research on green leaves extract of S. myrtafolium is suggested for further research as anticancer. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/969 10.36656/jpfh.v5i1.969 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 26-35 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/969/650 Copyright (c) 2022 Desy Muliana Wenas

oai:ojs2.ejournal.delihusada.ac.id:article/972 2022-10-31T06:43:12Z JPFH:FAR driver

UJI EFEK ANTIPIRETIK DAUN SENDUDUK (Melastoma malabathricum L.) PADA TIKUS PUTIH JANTAN (Rattus Norvegicus) Gultom, Evi Depiana Zebua, Herti Ayu N Rambe, Robiatun The antipyretic effect of flavonoid in senduduk leaf (Melastoma malabathricum L.) is one of the traditional medicines that people used. The goal of this study is to determine the antipyretic effect of the extract of Senduduk leaf (Melastoma malabathricum L.) in male white mice and compare it to paracetamol. The design of this experimental study was a post-test only controlled group design. Twenty-five Wistar furrow mice, aged two months and weighing 200 grams, were utilized as animal models. The mice were divided into five groups, one of which was the negative control group (2 ml water), First dosage of Senduduk leaf extract (100 mg/200 g body weight mice), second dose of the extract (200 mg/200 g body weight mice), and third dose of the extract (300 mg/200 g body weight mice). Temperature measurements were taken before and after the DPT vaccination was administered to mice, and every 30 minutes post treatment until 150 minutes. The result after observing treatment at 30 minutes for dose I (37.930C), dose II (37.760C), and dose III (37.450C). The results at 150 minutes for dose I (37,470C), for dose II (37,150C), and for dose III (36.880C). The result of the research was to analyzed using the one way ANOVA test. The results of statistical observations using the one way ANOVA method showed the significant value was p < 0.05 (0.000). This indicates there are differences from each treatment in antipyretic testing. If continued with the Tukey test, a significant value of p> 0.05 (0.9480), the research concluded that there is no difference in terms of antipyretic testing at a dose of 300mg/KgBW compared to paracetamol. The research concluded is the EEDS at a dose of 300mg/KgBW has the best antipyretic properties compared to paracetamol. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/972 10.36656/jpfh.v5i1.972 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 36-44 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/972/651 Copyright (c) 2022 Evi Depiana Gultom, Herti Ayu N Zebua, Robiatun Rambe

oai:ojs2.ejournal.delihusada.ac.id:article/984 2022-10-31T06:43:12Z JPFH:FAR driver

E EFEKTIVITAS ANALGETIK EKSTRAK BATANG PEPAYA (Carica papaya L.)PADA MENCIT JANTAN YANG DIINDUKSI LEMPENG PANAS Rahmi, Sofia - Papaya stems (Carica papaya L.) are experimentally utilized by the community as new vegetables. Dried papaya stems contain auxiliary metabolites of flavonoids, tannins, glycosides, polyphenols, steroids and triterpenoids. This compound acts as an antioxidant. The flavonoid compounds found in papaya stems act as analgesics. The point of this ponder was to look at the pain relieving impact of papaya stems on male rats initiated by warm plate. Making wounds on creatures by implies of warming plates made with a estimate of 1cm x 1cm. The hair on the mice's backs was shaved, a warming cushion was connected to the mice's backs for around 2 seconds until they come to the dermis and fundamental tissue, causing the skin to rankle and peel in a few places. Pain relieving perceptions in test creatures were given after acceptance by regulating CMC-Na, paracetamol, papaya stem ethanol extricate at measurements of 100 mg/kgBW, 300 mg/kgBW and 600 mg/kgBW. Papaya stem extricate contains auxiliary metabolites of flavonoids, tannins and saponins that act as analgesics. At a measurements of 600 mg/kg body weight, the extricate had an pain relieving impact comparable to that of paracetamol. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/984 10.36656/jpfh.v5i1.984 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 45-50 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/984/653 Copyright (c) 2022 Sofia - Rahmi

oai:ojs2.ejournal.delihusada.ac.id:article/990 2022-10-31T06:43:12Z JPFH:FAR driver

FORMULASI SEDIAAN SALEP ANTI FUNGI EKSTRAK ETANOL BAWANG PUTIH (Allium sativum) TERHADAP PERTUMBUHAN JAMUR (Tricophyton mentagrophytes) SECARA IN VITRO Fahdi, Firdaus Sari, Herviani Garlic contains flavonoids, tannins, and saponins which act as antifungals. The purpose of this study was to formulate an ethanol extract of garlic (Allium sativum) ointment with various concentrations of 5%, 10%, 15% and to evaluate the ointment preparation with physical evaluation requirements. Testing the activity of the ointment preparation against the fungus Trichophyton mentagrophytes was carried out by the diffusion method. The results showed that garlic (Allium sativum) could be formulated as an antifungal ointment preparation and met the requirements of the ointment preparation evaluation test with the results of the organoleptic test of the white ointment base, the 5% formulation being pale yellow, the 10% formulation and 15% brownish yellow. The homogeneity test showed no lumps in the ointment preparation, the pH test was in accordance with the requirements, namely 4.5-6.5. The dispersion test was in accordance with the requirements, namely 5-7 cm, and the adhesive data test was in accordance with the requirements, which was more than 4 seconds. The results showed that garlic (Allium sativum) ethanol extract ointment could inhibit the fungus Trichophyton mentagrophytes where a concentration of 15% produced an inhibition zone of 10.4500 mm, and as a comparison, miconazole ointment produced an inhibition zone of 14.3833 mm. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/990 10.36656/jpfh.v5i1.990 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 165-178 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/990/654 Copyright (c) 2022 Firdaus Fahdi, Herviani Sari

oai:ojs2.ejournal.delihusada.ac.id:article/995 2022-10-31T06:43:12Z JPFH:FAR driver

UJI CEMARAN MIKROBA Coliform DAN IDENTIFIKASI Escherichia coli PADA SEDIAAN JAMU QUSTHUL HINDI YANG BEREDAR DI PASARAN Nengsih, Amelia Rahmawati The need to maintain endurance during the Covid-19 pandemic has increased the intensity of people consuming herbal medicine. The Qusthul Hindi herbal medicine comes from the qust plant. This plant has the potential to treat various human ailments, including respiratory, digestive, and metabolic disorders. Making herbal medicine that is still very simple allows herbal medicine to be contaminated by microbes. This study aims to identify the presence of Coliform microbial contamination and E. coli bacteria in Qusthul Hindi herbal preparations circulating in the market. The five samples of Qusthul Hindi herbal medicine used in this study were obtained from several shops in Indonesian e-commerce. The Coliform microbial contamination test was conducted using the Most Probable Number (MPN) method. The MPN test consists of 2 stages: a presumptive test using Lactose Broth media and a confirmed test using Escherichia coli Broth media. MPN calculation is based on the number of positive test tubes. Positive test tube observations can be seen by observing the emergence of turbidity or the formation of gas contained in the Durham tube. The MPN value is calculated from the combination of positive tubes in the MPN table. The identification of Escherichia coli was tested using Eosin Methylene Blue Agar (EMBA) selective media, and then gram staining was performed. From the results of the estimator test, confirmatory test, selective medium test to gram staining, it showed that five Qusthul Hindi herbs tested were positively contaminated by Coliform microbes and all samples showed positive results for Escherichia coli contamination. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/995 10.36656/jpfh.v5i1.995 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 51-58 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/995/657 Copyright (c) 2022 Amelia Rahmawati Nengsih

oai:ojs2.ejournal.delihusada.ac.id:article/1000 2023-05-31T13:47:19Z JPFH:FAR driver

FORMULASI DAN UJI MUTU FISIK SEDIAAN GEL EKSTRAK BUNGA TELANG (Clitoria ternatea L.) SEBAGAI ANTISEPTIK TANGAN Farhan, Moh Hands are one of the media for microbial growth, dirty hands become a breeding ground for microbes such as Staphylococcus aureus and Escherichia coli or other bacteria. How to maintain hand hygiene is to wash your hands with soap or use an antiseptic (hand sanitizer). Antiseptic preparations are substances that have been widely used to inhibit the growth and kill microorganisms that exist around the body surface, for example on the palms of the hands that often come into contact with the surface of an object. One of the natural ingredients that has the potential to be developed as a hand antiseptic is telang flower (Clitoria ternatea). This research will formulate antiseptic gel preparations from telang flower extract, and how to test the physical quality of antiseptic gel preparations from telang flower extract. The method used for the extraction process here uses the maceration method, to maintain the antimicrobial compounds contained in the telang flower, followed by testing the physical characteristics and quality of the telang flower gel preparation, including, Organoleptic Test, pH test, Viscosity test, Homogeneity test, Spreadability test, adhesion test. After testing the characteristics and physical quality of the gel preparations of telang flower extract, the results were quite optimal, namely with a pH value in the range of 4.26-4.41 according to skin pH, and for viscosity at a value of 64% - 33%, in accordance with the characteristics of a good gel. Telang flower extract can be made and formulated as an antiseptic hand gel preparation. Variations in the concentration of the extract used greatly affect the characteristics of the gel preparation, starting from pH, viscosity, adhesion, and dispersion. The higher the concentration of the extract used, the lower the viscosity value, and the lower the pH value. The pH value and viscosity value for all formulas were in accordance with the skin parameter criteria, namely 3.5-6.5. Based on research conducted, Formula 3 using a concentration of 0.5 has. the most optimal gel preparation Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2023-05-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1000 10.36656/jpfh.v5i2.1000 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 2 (2023): JURNAL PENELITIAN FARMASI & HERBAL; 1-12 2654-7619 10.36656/jpfh.v5i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1000/757 Copyright (c) 2023 Moh Farhan

oai:ojs2.ejournal.delihusada.ac.id:article/1001 2022-10-31T06:43:12Z JPFH:FAR driver

EVALUASI UJI EFEKTIVITAS EKSTRAK KAYU MANIS (Cinnamomum burmanni) SEBAGAI LARVASIDA TERHADAP KEMATIAN JENTIK NYAMUK (Aedes aegypti) R, Ike Widiya Alternative larvicides against Aedes aegypti larvae and safe for the environment, one of which is cinnamon oil which has been shown to have a larvicidal effect on larvae. Cinnamon contains flavonoid compounds which are strongly suspected to have a larvicidal effect. It can be said that this research is to determine the effectiveness of extracts from cinnamon as a larvicide against the death of Aedes aegypti mosquito larvae. And for the extraction method used in this study using the maceration method. For a concentration of 2% it can kill a total of 32 (53%) larvae, and for a concentration of 4% it can kill 43 (72%) total lava, and a concentration of 6% can kill 53 (88%) larvae, and for a positive control, namely abate (temephos). ) has the best larvicidal effect with an average % larval mortality of 100% within 1 hour. Cinnamon extract test treatments with a concentration of 2% (2ml/100ml) experienced larval death 32 (43%), and for a concentration of 4% (4ml/100ml) experienced larvae mortality 43 (53%). and for a concentration of 6%, 53 (88%) larvae died. And for temephos, it was able to kill a total of all larvae, while for negative control it did not die. The most effective concentration of cinnamon extract in killing larvae was 6%, the higher the concentration, the higher the larval mortality value. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1001 10.36656/jpfh.v5i1.1001 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 59-67 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1001/658 Copyright (c) 2022 Ike Widiya R

oai:ojs2.ejournal.delihusada.ac.id:article/1020 2022-10-31T06:43:12Z JPFH:FAR driver

ANALISIS TINGKAT KEPUASAN PASIEN ANALISIS TINGKAT KEPUASAN PASIEN RAWAT JALAN PESERTA BPJS KESEHATAN TERHADAP PELAYANAN FARMASI DI INSTALASI RSU SEMBIRING Syafitri, Anggun Lubis, Bintang Purba, Jhan Saberlan Sitio, Sri Sudewi Pratiwi Sembiring, Efrata Damanik, Yunita Syaputri Quality health services are health services that can satisfy every user of health services in accordance with the level of satisfaction. Satisfaction will occur if the expectations of the patient can be met by the services provided by the hospital so that it needs to be considered continuously the satisfaction and expectations of the patient. The purpose of this study was to determine the level of satisfaction of outpatients of BPJS Kesehatan participants with pharmaceutical services at the outpatient Pharmacy Installation at RSU Sembiring. The design of this study used descriptive survey research. The population in this study was 1400 patients, and the sample was 93 patients using the Slovin formula. Data collected through primary and secondary data and using univariant and bivariant analysis with the help of the SPSS computer program. The results of the chi square test obtained variables related to the satisfaction of outpatients at the general hospital, namely: Physical evidence (p value = 0.002), Reliability (p value = 0.000, Responsiveness (p value = 0.002), Guarantee (p value = 0.004), and Empathy (p value = 0.000). It is recommended to the Outpatient Pharmacy of Sembiring General Hospital to maintain a good quality of service and continue to improve the quality of service to patients. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1020 10.36656/jpfh.v5i1.1020 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 158-164 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1020/645 Copyright (c) 2022 Anggun Syafitri, Bintang Lubis, Jhan Saberlan Purba, Sri Sudewi Pratiwi Sitio, Efrata Sembiring, Yunita Syaputri Damanik

oai:ojs2.ejournal.delihusada.ac.id:article/1034 2022-11-02T08:28:40Z JPFH:FAR driver

STANDARISASI SIMPLISIA DAUN KELOR (Moringa oleifera L.) DARI DESA LUWUNG SIDOARJO DENGAN MENGGUNAKAN PENGERINGAN FOOD DEHYDRATOR AZIZAH, MELLA NUR NINGSIH, ARISTA WAHYU SINAGA, BUTET One of the vegetation that may be used each as meals and medication is the Moringa plant (Moringa oleifera L.). Empirically, Moringa leaves have many advantages and had been proven to be powerful in treating numerous diseases, consisting of diabetes, hepatitis, heart ailment and excessive cholesterol. The chemical parts contained on this plant are terpenoids, tannins, steroids, polyphenols, and alkaloids. This look at aims to pick out medicinal uncooked substances the use of the meals dehydrator drying method whilst on the equal time making sure the drug raw materials, so that the standardization can be accounted for for its quality. Standardization is done by setting specific and non-specific parameters. This study uses descriptive qualitative and quantitative analysis methods. The sample of this research was taken from Luwung village, Sidoarjo regency. The results of standardization for specific parameters showed the determination of the flavonoid content of 16,08±3,62 mgQE/g, the TLC test showed stains in the form of yellow-green fluorescence under UV light at 366 nm, the water-soluble extract test yielded 7.8%, and the water-soluble extract test yielded 7.8%. ethanol yielded 13.58%. The results for non-specific parameters showed that drying shrinkage was 4.2%, water content was 1.80%, and ash content was 1.4%. The results of the microbial contamination test were 3.9x  colonies/ml while the total mold/yeast contamination was 3.1x  colonies/ml. Based at the results of studies that has been carried out, Moringa leaf simplicia from Luwung village has met the requirements of specific and non-specific parameters, so that the simplicia may be used as raw material for medication. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-11-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1034 10.36656/jpfh.v5i1.1034 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 76-85 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1034/659 Copyright (c) 2022 ARISTA WAHYU NINGSIH, Mella Nur Azizah, Butet Sinaga

oai:ojs2.ejournal.delihusada.ac.id:article/1038 2022-10-31T06:43:12Z JPFH:FAR driver

ANALISIS CEMARAN LOGAM BERAT TIMBAL (Pb) PADA MAKANAN DAN MINUMAN : STUDI LITERATUR Aribowo, Audi Ichsani Annisa, Bunga Nur Sary, Nena Vauziah Nurfadhila, Lina Utami, Marsah Rahmawati Heavy metals are defined as the transition elements that have a high atomic mass, are toxic, and cannot be broken down by living organisms. Metal Lead (Pb) is one of the heavy metals which are widely distributed in the environment. Heavy metal lead is one of the causes of serious health problems because it can cause disturbances to the human body. Therefore, the aim of this literature review is to present an illustration and up-to-date data on the analytical methods used for food and beverages contaminated with lead heavy metal (Pb). The methodology of this research is a literature review study from several databases such as Science Direct, Pubmed, and Google Scholar with a limitation of publication in the last 10 years. The results of a literature review from the analysis of Pb metal contamination in food and beverages, there are several techniques that can be utilized to analyze and various factors that cause the amount of lead (Pb) levels such as the atomic absorption spectrophotometer (AAS) method. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1038 10.36656/jpfh.v5i1.1038 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 86-98 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1038/660 Copyright (c) 2022 Audi Ichsani Aribowo, Bunga Nur Annisa, Nena Vauziah Sary, Lina Nurfadhila, Marsah Rahmawati Utami

oai:ojs2.ejournal.delihusada.ac.id:article/1056 2023-05-31T13:47:19Z JPFH:FAR driver

Keywords: Antioxidant, DPPH, Turmeric Instant Powder, UV-Vis Spectrophotometer and IC50 value. alfian, muhammad Abstract Turmeric and tamarind herbal medicine is one of the drinks with turmeric and tamarind as raw materials which is quite widely consumed by the community, either in liquid form or in powder form. Jamu turmeric acid can be used to prevent the negative effects of free radicals on the body because there are active antioxidant compounds, besides that it can be used as a natural antioxidant. There are many natural antioxidants in nature, one of which is in traditional medicine. The content of Jamu turmeric acid is curcuminoids where this compound is useful as an anti-inflammatory and antioxidant. This study aims to determine the antioxidant activity of instant turmeric powder drink produced by of UMKM Healthy Partners, Kiringan Bantul herbal tourism village, using the DPPH method (2,2-diphenyl-1-picrylhydrazyl). The absorbance measurement to determine the antioxidant activity of each sample of turmeric tamarind powder was tested using a UV-Vis spectrophotometer at a maximum wavelength of 516 nm. Determination of antioxidant activity by the DPPH method is expressed by the IC50 (Inhibiton Concentration 50) value. The results showed that the antioxidant activity of the instant turmeric powder drink (Curcuma domestica val.-tamarindus indica l.) produced by Mitra Sehat SME in the Jamu Kiringan Tourism Village, Bantul, was included in the very weak category with an IC50 value of each sample successively. The participants were sample A of (276.005 ppm), sample B of (265.434 ppm), and sample C of (256.183 ppm). Keywords: Antioxidant, DPPH, Turmeric Instant Powder, UV-Vis Spectrophotometer and IC50 value. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2023-05-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1056 10.36656/jpfh.v5i2.1056 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 2 (2023): JURNAL PENELITIAN FARMASI & HERBAL; 13-19 2654-7619 10.36656/jpfh.v5i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1056/758 Copyright (c) 2023 muhammad alfian

oai:ojs2.ejournal.delihusada.ac.id:article/1057 2022-10-31T06:43:12Z JPFH:FAR driver

GAMBARAN PENGETAHUAN DAN UPAYA SWAMEDIKASI MAHASISWA FAKULTAS KESEHATAN MASYARAKAT UIN SUMATERA UTARA MEDAN Wahyudi, Wahyudi Swamedikasi merupakan upaya diri untuk menggunakan atau memperoleh obat tanpa diagnosis, resep, pengawasan ataupun konsultasi dengan dokter untuk mengobati suatu penyakit ringan tertentu. Penelitian ini bertujuan Untuk mendeskripsikan  pengetahuan dan upaya mahasiswa Fakultas Kesehatan Masyarakat UIN Sumatera Utara Medan. Penelitian ini merupakan penelitian kuantitatif deskriptif menggunakan menggunakan metode survey. Pengumpulan data dilakukan dengan kuesioner via google form yang selanjutnya dianalisis untuk dapat  mendeskripsikan hasil penelitian. Hasil penelitian menunjukkan bahwa tingkat pengetahuan swamedikasi mahasiswa FKM UIN Sumatera Utara termasuk kategori kurang baik dimana 52,7% mahasiswa belum familiar dengan istilah swamedikasi dan hanya 25,9% yang mengetahui bahwa antibiotik harus dibeli dengan resep dokter. Upaya swamedikasi mahasiswa termasuk kategori baik karena 62,5% mahasiswa melakukan upaya swamedikasi jika mengalami sakit ringan,  43,8% mengetahui aturan pakai obat dari apoteker/asisten apoteker dan 52,7% mengetahuinya dari kemasan obat. Penelitian ini juga menunjukkan bahwa mahasiswa telah melakukan persiapan swamedikasi dengan cara menyimpan obat yang akan digunakan saat mereka sakit. Kesimpulan dari penelitian ini adalah tingkat pengetahuan swamedikasi mahasiswa FKM UIN Sumatera Utara termasuk kategori kurang baik (36,6%) dan upaya swamedikasi termasuk kategori baik (80,36%). Obat yang paling banyak disimpan sebagai persiapan swamedikasi adalah obat penurun demam (82,1%). Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1057 10.36656/jpfh.v5i1.1057 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 99-106 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1057/661 Copyright (c) 2022 Wahyudi Wahyudi

oai:ojs2.ejournal.delihusada.ac.id:article/1059 2023-05-31T13:47:19Z JPFH:FAR driver

UJI EFEKTIVITAS SALEP EKSTRAK ETANOL DAUN SIRIH CINA (Peperomia pellucida) TERHADAP PENYEMBUHAN LUKA EKSISI PADA TIKUS PUTIH (Rattus norvegicus) Sari, Rika Puspita ABSTRAK Wahyuni. Test the effectiveness of Chinese betel leaf ethanol extract ointment on excision wound healing in white rats (Supervised by: apt.Rika Puspita Sari, S.farm.,M.Si )   Wounds are physical injuries that can cause tears and damage to skin tissue. One type of the wound is an excision wound. An excision of wound caused by the cutting of tissue by a sharp object. The main goal in wound management is to achieve rapid healing with optimal fuction and good result. That  can be achieved by preventing infection and trauma by providing an environtment that optimizes wound healing. One of the plants that have the potential to heal wounds is the Chinese betel plant that have the potential to heal wounds is the Chinese betel plant the purpose of the research  to determine the effectiveness of giving Chinese betel leaf extract on excision wound healing in white rats(rattus norvegicus). The research was conducted in the laboratory of health the husada deli tua. The method of the research conducted out experimentally, the sample was extracted by the maceration method. And then the extract was formulated into ointment availability with concentrations of 2%,4%, and 8% furthermore, on evaluation of the availability of the ointment was carried out, by organoleptic test, homogeneity test, pH test and spreadability test. The result of the research for each group gave the best treatment experienced a decrease in the diameter of the cut wound was the positive control group (povidone iodine) and 8% concentration. Conclusions: the ethanol extract of chial betel leaf has the effectiveness of healing excision wounds at a concentration of 8% Keywords: Chinese betel leaf extract, excision wound   Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2023-05-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1059 10.36656/jpfh.v5i2.1059 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 2 (2023): JURNAL PENELITIAN FARMASI & HERBAL; 20-26 2654-7619 10.36656/jpfh.v5i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1059/759 Copyright (c) 2023 Rika Puspita Sari

oai:ojs2.ejournal.delihusada.ac.id:article/1060 2022-10-31T06:43:12Z JPFH:FAR driver

PENYALAHGUNAAN AMFETAMIN DAN DAMPAK PENGGUNA TERHADAP KESEHATAN DAN SOSIAL : LITERATURE REVIEW Annisa, Bunga Nur Hilmi, Indah Laily Salman, Salman Drug abuse is defined as the use of one or more types of drugs without medical regulations or not according to indications so that it has various side effects, including physical, psychological, and social dysfunction. One of the drugs that are often used by the public is amphetamine because amphetamine causes euphoria and a sense of calm (psychotropic group). Hence, the purpose of this literature review is to provide an overview and the most recent information regarding the effects of amphetamine use. The method for this literature analysis is by evaluating references from Science Direct, PubMed, and Google Scholar, with a publication restriction of the previous 10 years. Based on the relevant literature, amphetamine misuse has diverse impacts on its users. Drug abuse has psychological and physical effects on adolescents (students) to adults and affects a person's social interactions. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1060 10.36656/jpfh.v5i1.1060 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 107-114 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1060/662 Copyright (c) 2022 Bunga Nur Annisa, Indah Laily Hilmi, Salman Salman

oai:ojs2.ejournal.delihusada.ac.id:article/1063 2022-10-31T06:43:12Z JPFH:FAR driver

A ntihypercholesterolemia UJI EFEKTIVITAS ANTIHIPERKOLESTEROLEMIA EKSTRAK DAUN KOPI ARABIKA (Coffea arabica L.) PADA TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI DIET TINGGI LEMAK Meliala, Linta Hypercholesterolemia is a condition that cholesterol in the blood increases beyond the normal which is one of the risk factors for cardiovascular disease. Arabica coffee leaves are part of the arabica coffee plant which contains flavonoid, saponin, mangiferin, chlorogenic acid which are thought to reduce cholesterol levels in the blood. This study aims to determine the antihypercholesterolemia effectiveness of arabica coffee leaves ethanol extract (ACLEE) in male rats induced by a high-fat diet. The test of antihypercholesterolemia effectiveness used male rats induced by a high-fat diet as test animals. The study used 25 rats and divided into 5 groups : negative control (CMC-Na 0.5%), positive control (simvastatin 0.9 mg/kgBW), ACLEE 200 mg/kgBW, ACLEE 300 mg/kgBW and ACLEE 400 mg/kgBW. Total cholesterol were measured by the CHOD-PAP method. The data obtained were analyzed statistically used one way Anova. The results of statistical analysis showed that there was a significant difference between negative control with positive control, ACLEE 200, 300 and 400 mg/kgBW (p-value<0.05). The decrease in total cholesterol levels increased in line with the increase in the dose of arabica coffee leaves ethanol extract. The most effective of ACLEE as antihypercholesterolemia was ACLEE 400 mg/kgBW. There was no significant difference between positive control and ACLEE 400 mg/kgBW (p.>0.05). Based on the results of statistical analysis, it can be concluded that the arabica coffee leaves ethanol extract has antihypercholesterolemic effect in rats.   Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1063 10.36656/jpfh.v5i1.1063 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 115-121 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1063/663 Copyright (c) 2022 Linta Meliala

oai:ojs2.ejournal.delihusada.ac.id:article/1065 2022-10-31T06:43:12Z JPFH:FAR driver

FORMULASI SEDIAAN CREAM DAN UJI AKTIVITAS ANTIBAKTERI PADA EKSTRAK ETANOL KOMBINASI KULIT PISANG (Musa paradisiaca) DAN KULIT NANAS (Ananas comosus) TERHADAP BAKTERI PENYEBAB JERAWAT Propionibacterium acnes Sembiring, Pintata Background: Acne vulgaris is a chronic inflammatory skin disease with a complex pathogenesis, involving  sebaceous glands, follicular hyperkeratosis, bacterial overgrowth, immune  and inflammatory responses. Objective: This formulate the ethanol extract of banana peel and pineapple peel into cream preparations and to test the effective antibacterial activity of the combination of banana peel and pineapple peel ethanol extract cream against Propionibacterium acnes. Methods: This research was conducted experimentally with maceration extraction using 70% ethanol as solvent. Acne cream is made with a concentration ratio between (Banana peel: Pineapple peel) namely F1 (Cream Base), F2 (5%:15%), F3 (7.5%:12.5%), F4 (10%:10% ), F5 (12.5%:7.5%), F6 (15%;5%), F7 (20%:0%) and F8 (0%;20%). Then, the physical stability test was carried out in the form of organoleptic test, viscosity test, pH test, homogeneity test, spreadability test and cream type test. Followed by testing the bacteria Propionibacterium acnes in Na media. Results: The antibacterial activity test on F3 showed that the diameter of 20.18 mm was relatively larger than F1 of 0mm, F2 of 18.63 mm, F4 of 18.38 mm, F5 of 16.48 mm, F6 of 18.28 mm, F7 of 13.91 mm and The F8 is 16.11 mm. Conclusion: Cream preparations from formula 1 to formula 8 the cream stability organoleptic test, viscosity test, pH test, homogeneity test, test spreadability and cream type test. The cream preparation in formula 3 has the widest diameter for antibacterial activity compared to other formulas. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1065 10.36656/jpfh.v5i1.1065 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 122-129 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1065/664 Copyright (c) 2022 Pintata Sembiring

oai:ojs2.ejournal.delihusada.ac.id:article/1066 2023-05-31T13:47:19Z JPFH:FAR driver

FORMULASI SEDIAAN SALEP KOMBINASI EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) DAN DAUN KERSEN (Muntingia calabura L.)TERHADAP PENYEMBUHAN LUKA TERBUKA PADA TIKUS JANTAN PUTIH TAHUN 2022 sianipar, masria phetheresia Background: Wounds are damage to part of body tissue or damage to tissue components, where there are damaged or missing tissue substances. Jackfruit leaves (Artocarpus heterophyllus Lam.) contain secondary metabolites, namely, flavonoids, saponins and tannins. Flavonoids function as antibacterial and reduce inflammation in wounds. Saponins to trigger the formation of collagen. While the tannins function as an antibacterial. Cherry leaves (Muntingia calabura L.) contain several active compounds such as flavonoids, saponins, and tannins. Compounds that function as anti-inflammatory are flavonoids. These compounds can accelerate wound healing because it has anti-inflammatory activity.  Objective: to determine the concentration of the combination ointment of jackfruit leaf and cherry leaf ethanol extract in the form of an ointment that is most effective in healing open wounds. Method : Experimentally. Samples using jackfruit and cherry leaves were taken purposively, extracted by maceration using 96% ethanol as a solvent made in the form of a thick extract. Then the thick extract was made into an ointment with a ratio of 1:2, 2:1 and 2:2 as well as positive control (bacitracin ointment), negative control (ointment base). open wound for 14 days. Results: The results of the open wound healing study had the best effectiveness, namely bacitracin ointment (0 cm), a combination ointment of jackfruit leaf and cherry ethanol extract 2:2 (0.10 cm), 1:2 (0.25 cm) and 2 :1 (0.28 cm) then ointment base (0.55 cm). Conclusion : The preparation of ointment combination of jackfruit leaf ethanol extract and 2:2 cherry is more effective in the treatment of open wounds. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2023-05-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1066 10.36656/jpfh.v5i2.1066 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 2 (2023): JURNAL PENELITIAN FARMASI & HERBAL; 27-33 2654-7619 10.36656/jpfh.v5i2 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1066/760 Copyright (c) 2023 masria phetheresia sianipar

oai:ojs2.ejournal.delihusada.ac.id:article/1067 2022-10-31T06:43:12Z JPFH:FAR driver

STUDI FARMAKOVIGILANS PADA OBAT HERBAL Sa'adah, Cantika Nurul There is a trend of "back to nature" which has become the lifestyle of today's society, so that people return to using various natural ingredients in medicine. A drug side effect is any adverse and unwanted response to a drug that occurs at doses normally used in humans for the treatment of disease, diagnosis, prevention, or modification of physiological function. Pharmacovigilance is carried out with the aim of monitoring drug safety by detecting an increase in the incidence of Advers Drugs Reaction (ADR). This review was conducted to see an overview of the initial data/reports on the relationship between the use of herbal medicines and the incidence of ADR. As a result, it is known that the percentage of ADR events in various places is 19%, 12%, 13.36% and 10-15% with possible and probable categories. The types of herbal medicines used are white turmeric, fitsea, garcia, ginger water, turmeric, herbalife, niran, calcusol, vegeta, tensigard, diapet, herbal vegeta, diabetes herbs, hypertension herbs, cholesterol herbs, kidney stone herbs, anti-inflammatory analgesic herbs, herbal medicine for asthma and herbal medicine for diarrhea. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1067 10.36656/jpfh.v5i1.1067 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 130-135 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1067/665 Copyright (c) 2022 Cantika Nurul Sa'adah

oai:ojs2.ejournal.delihusada.ac.id:article/1069 2022-10-31T06:43:12Z JPFH:FAR driver

ANALISIS KADAR ASAM ASETAT HASIL FERMENTASI ECO-ENZYME DARI KULIT JERUK BALI (Citrus maxima Merr.) DAN POTENSINYA SEBAGAI ANTIOKSIDAN DENGAN METODE ALKALIMETRI DAN DPPH sembiring, bungamri The garbage problem is a very important problem because it has the potential to damage the balance of the environmental ecosystem. Many studies have been carried out on the content of active compounds in grapefruit peel, but there are differences in sampling locations, types of solvents for extraction, differences in treatment and testing. In the discovery of Eco-enzyme fermentation solution product, Dr. Rosukon Poompanvong to help local farmers to obtain better yields while being friendly to the environment. Eco-Enzyme is a popular fermented fruit peel organic waste which has been developed because it is very practical, economical, and environmentally friendly. Utilization of fruit peels into Eco-Enzyme is an evolution of science in the health sector. This study aims to determine the Eco-Enzyme fermentation process from pomelo peel and Eco-Enzyme acetic acid levels and their potential as antioxidants with experimental research using Eco-Enzyme sample solution with FeCl3 solution as a qualitative test indicator for Eco-Enzyme samples. Quantitative test using 1-2 drops of Eco-Enzyme sample solution 0,1 M NaOH standard solution and phenolphthalein indicator solution in alkalimetric titration and DPPH method with DPPH solution using UV-Vis spectrophotometer. From the results of qualitative research, the results of Eco-Enzyme fermentation are in the form of a light brown solution, have a brick red precipitate, and there is a brick red precipitate. The results of quantitative research on alkalimetric titration of Eco-Enzyme fermentation, there is an acetic acid level of 7.5% per one gram of pomelo peel, and the DPPH method on the fermented Eco-Enyme solution with an IC50 value of 9.418075752 ppm, which means it has very strong antioxidant potential. Eco-enzyme sample solution has acetic acid level of 7,5% per one gram of pomelo peel and has very strong antioxidant potential Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1069 10.36656/jpfh.v5i1.1069 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 136-141 2654-7619 10.36656/jpfh.v5i1 eng https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1069/666 Copyright (c) 2022 bungamri sembiring

oai:ojs2.ejournal.delihusada.ac.id:article/1078 2022-10-31T06:43:12Z JPFH:FAR driver ec_fundedresources

Uji UJI EFEKTIVITAS GEL EKSTRAK ETANOL 70% GETAH GAMBIR (Uncaria gambir. Roxb) dan BETADINE TERHADAP LUKA SAYAT PADA TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR sulasmi, sulasmi Gambir (Uncaria gambir. Roxb) contains flavonoids, tannins, saponins and alkaloids that can help heal wounds. One of the main ingredients that gambir contains is catechins . Catechins are flavonoid compounds with anti-inflammatory, antioxidant and antibacterial properties derived from Gambir. This study aimed to compare wound healing time between ethanolic extracts of 70% gambir resin gel (Uncaria gambir. Roxb) with betadin preparations in male Sprague dawley rats (Rattus norvegicus). A total of 9 white rats (Rattus norvegicus)  strain Sprague dawley were divided into 3 groups, a negative control group for gel  base  treatment and a positive control group for gambir sap gel  preparations (Uncaria gambir. Roxb)  betadine comparison group.  This study was conducted by experimental method with a post-trial controlled group design. Each group is colored with group preparations, the treatment is carried out 3 × 1 every day. Wound healing time was analyzed by a one-way Anova test on spss. Healing ingroup I was 10.6 days, in group II, 10.3 days in group III and 9.3 days. Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1078 10.36656/jpfh.v5i1.1078 Jurnal Penelitian Farmasi Dan Herbal; Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL; 142-149 2654-7619 10.36656/jpfh.v5i1 eng info:eu-repo/grantAgreement/EC/FP7/884920 https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1078/667 info:eu-repo/semantics/openAccess Copyright (c) 2022 sulasmi sulasmi 0abca5466a477fd3fa95dd8010fe7941