Jurnal Penelitian Farmasi & Herbal

UJI EFEKTIVITAS EKSTRAK ETANOL DAUN BANDOTAN (Ageratum conyzoides) SEBAGAI ANTIDIARE

Pintata Sembiring — Fri, 10 Nov 2023 04:27:51 SE Asia Standard Time

Diarrhea is an abnormal stool that is thinner than usual and occurs more than three times a day. Bandotan leaves have antibacterial properties. This study was an experimental study using 25 rats induced with oleumricin and divided into five groups, the negative control group of 1% CMC- Na, the positive control of Loperamide HCl and the group of bandotan leaf ethanol extract doses of 100 mg/kg, 150 mg/kg and 200 mg/kg. Bandotani leaves (Ageratum conyzoides) as samples were extracted by soaking using 96% ethanol then concentrated by spinning. The results of the phytochemical screening of bandotan leaves obtained flavanoid compounds, saponins, tannins, alkaloids. The results of the anti-diarrhea effect with EEDB doses of 100, 150 and 220 mg/kg showed an anti-diarrhea effect in male rats, the best anti-diarrhea effect was the average EEDB dose of 150 mg/kg. compared doses of 100 and 150 mg/kg. Bandotani leaf extract (Ageratum conyzoides) has antidiarrheal activity induced by oleumricin in male white rats.

REVIEW PENGARUH PENGGUNAAN SURFAKTAN PADA KARAKTERISTIK SEDIAAN ORODISPERSIBLE FILM (ODF) OBAT BERKELARUTAN RENDAH DALAM AIR: SIFAT DISINTEGRASI DAN DISOLUSI

Nining Nining — Fri, 10 Nov 2023 04:28:01 SE Asia Standard Time

Orodispersible film (ODF) is a drug delivery gaining widespread acceptance because it disintegrates quickly and can be self-administered. ODF has the advantage of increasing the active pharmaceutical ingredient (API) effectiveness by rapid dissolution in the oral cavity after direct contact with saliva. One of the components of ODF that influences the physical characteristics and dissolution of low-soluble drugs in water is surfactant. This material acts as a wetting or dispersing agent so the film can quickly disintegrate and release API. The method used is searching for international journal data using the Google Scholar. The surfactants reported to have been used in the ODF formulation are L-arginine, poloxamer 407, tween 80, and sodium dodecyl sulfate. In general, surfactant usage significantly affects the disintegration behavior of the film and API release. This behavior is caused by reducing the interfacial tension between phases by surfactants, which causes increased solid surface wetting and helps speed up the film disintegration and API dissolution from the ODF matrix. The conclusion is that surfactant usage with the appropriate type and concentration will help improve the ODF quality, especially in the disintegration properties of the dosage form and API dissolution.

GAMBARAN UMUM PASIEN RAWAT JALAN DI RUMAH DAN EVALUASI PELAYANAN INFORMASI OBAT DI INSTALASI FARMASI RUMAH SAKIT UMUM SEMBIRING DELI TUA

Anggun Syafitri, Viktor Edyward Marbun — Fri, 10 Nov 2023 04:28:27 SE Asia Standard Time

Drug Information Service (PIO) is one of the standards that must be applied to improve the best pharmaceutical services. Drug information services are very necessary for patients because complete drug information can determine the success of self-therapy at home, especially for outpatients. Provision of drug information has an important role to achieve optimal treatment results, Provision of drug information has an important role to achieve optimal treatment results, so as to improve the quality of life of patients. Pharmaceutical services at this time have shifted their orientation from drugs to patients referring to pharmaceutical care. This study used a descriptive observational research method with a cross sectional design and used a quantitative approach. This research was conducted at the Outpatient Installation of Sembiring Deli Tua General Hospital. The population is the entire object used in the study.

Uji Efektivitas Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Sebagai Antihiperurisemia Pada Tikus Putih Jantan Yang Di Induksi Kalium Oksonat

Evi Deviana Gultom — Fri, 10 Nov 2023 04:28:46 SE Asia Standard Time

Kersen plant (Muntingia calabura L.) is a plant that has many properties and is useful as medicine. Hyperuricemia is a condition where there is an increase in uric acid levels above normal. The leaf part of this plant is widely used by the community as a traditional medicine because of its metabolite compounds. Flavonoid compounds in cherry leaves can reduce uric acid levels through inhibition of the xanthine oxidase enzyme, an enzyme that acts as a catalyst in the oxidation process of hypoxanthine to xanthine and then to uric acid. By inhibiting the work of the xanthine oxidase enzyme, the formation of uric acid will also be inhibited. This study aims to determine the effectiveness of cherry leaf ethanol extract in reducing uric acid levels in male white rats induced by potassium oxonate. This study used an experimental method using 25 male white rats induced by potassium oxonate. The test animals were divided into 5 groups: negative control (CMC Na 1%), positive control (Allopurinol), EEDK dose of 300 mg/kgBB, EEDK dose of 400 mg/kgBB, EEDK dose of 500 mg/kgBB. Measurement of uric acid levels in rats using the point of care testing (POCT) method. All data obtained were analyzed statistically using the One Way Anova test. The results of the analysis showed that there were significant differences between the negative control, positive control, EEDK 300 mg/kg, EEDK 400 mg/kg, and EEDK 500 mg/kg (P<0.05). The most effective dose of cherry leaf ethanol extract as an antihyperuricemia is the EEDK dose of 500 mg/kg BW. There was no significant difference between EEDK 400 mg/kgBW, EEDK 500 mg/kgBW and positive control (P>0.05). Based on the results of the analysis that has been done, it can be concluded that the ethanol extract of cherry leaves has an antihyperuricemia effect in rats.

Keywords: Cherry leaves, Hyperuricemia, Potassium oxonate

linta meliala,roito yuliana UJI EFEKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN GAGATAN HARIMAU (Vitisgracilis BL) PADA TIKUS JANTAN PUTIH

Linta Meliala — Fri, 10 Nov 2023 04:29:00 SE Asia Standard Time

Abstract

Diarrhea is the abnormal passage of loose or watery stools, with a frequency of more than three times a day. Diarrhea can be caused by bacteria. Gagatan Harimau leaves are known to have antibacterial properties. This research was conducted using an experimental method in the field of pharmacology at the Pharmacology Laboratory, Faculty of Pharmacy, Deli Husada Health Institute Delitua, using 25 rats induced with castor oil and divided into 5 treatment groups: negative control (1% CMC Na), positive control (Loperamide HCl), and treatment groups with ethanol extract of Gagatan Harimau leaves at doses of 50 mg/kg body weight (BW), 100 mg/kg BW, and 200 mg/kg BW. The sample used was Gagatan Harimau leaves (Vitis graillis BL), which were extracted by maceration using 96% ethanol as the solvent and concentrated using a rotary evaporator. The phytochemical screening results of Gagatan Harimau leaves showed the presence of flavonoids, saponins, alkaloids, and tannins. The results of the antidiarrheal effect test showed that the ethanol extract of Gagatan Harimau leaves at doses of 50, 100, and 200 mg/kg BW had antidiarrheal effects on male rats. The 200 mg/kg BW dose of ethanol extract showed the most effective antidiarrheal effect compared to the 50 and 100 mg/kg BW doses. The extract from Gagatan Harimau leaves (Vitis gracillis BL) exhibited antidiarrheal effects on male white rats induced with castor oil.

UJI AKTIVITAS ANTIBAKTERI SEDIAAN OBAT KUMUR KOMBINASI EKSTRAK ETANOL BUNGA CENGKEH (Syzygium aromaticum) DAN KULIT JERUK LEMON (Citrus limon) TERHADAP BAKTERI Streptococcus mutans DAN Streptococcus viridans PENYEBAB KARIES GIGI DAN BAU MULUT

Nina Irmayanti Harahap, rika puspita sari, Zola Efa Harnis — Fri, 10 Nov 2023 04:29:13 SE Asia Standard Time

Dental caries is an infectious disease and is a process of progressive demineralization of the hard tissue surface of the crown and tooth roots caused by bacterial activity. microorganisms in the mouth. Plaque inhibition can be done with anti-microbial agents to suppress the activity of bacteria such as Streptococcus mutans. Streptococcus mutans is a cariogenic bacterium that causes cavities and is the most dominant in dental plaque. These bacteria can convert sucrose into lactic acid so that it can cause tooth demineralization (Haniyah, 2019). Lemon peel (Citrus limon) is known as an antibacterial ingredient. To facilitate the use of lemon orange peel extract, namely by making it into mouthwash preparations. Mouthwash is a solution that contains antibacterial substances to reduce the number of microorganisms in the mouth, is used as an oral rinse, and is easy to use (Ririn et al., 2019). Research using clove flower extract and lemon peel as antibacterial against Streptococcus mutans and Streptococcus viridans made in mouthwash preparations is still limited, therefore researchers are interested in conducting further research with the title test of antibacterial activity in mouthwash preparations combination of clove flower ethanol extract (Syzygium aromaticum) and lemon peel (Citrus limon) in inhibiting the growth of Streptococcus mutans and Streptococus viridans bacteria that cause bad breath can be formulated into mouthwash preparations and meet the evaluation test requirements for mouthwash preparations and the average diameter of the largest inhibition zone is 12, 31 mm for Streptococcus mutans at a concentration of 2%:0.5% and for Streptococcus viridans at a concentration of 2%:0.5%, namely 11.31.

AKTIVITAS ANTIOKSIDAN DAN KEMAMPUAN ANTIBAKTERI EKSTRAK KULIT BUAH KENITU (Chrysophyllum cainito L) TERHADAP Staphylococcus aureus

Lina Oktavia Rahayu — Fri, 10 Nov 2023 04:29:21 SE Asia Standard Time

Kenitu (Chrysophyllum cainito L) has strong antioxidant properties both in vitro and in vivo. The presence of this high antioxidant can be used as a natural agent to prevent and treat diseases associated with an imbalance of antioxidant levels in the body, such as diabetes. Some research results state that kenitu can be used as an antidiabetic. One type of complication in people with diabetes mellitus is the occurrence of bacterial infections of the skin. One type of bacteria that infects the most is Staphylococcus aureus. So far, the skin of the kenitu fruit has only been thrown away and has not been used. The purpose of this study was to determine the antioxidant activity of kenitu peel extract and to determine the ability of kenitu peel extract as an antibacterial against Staphylococcus aureus. Research methods included extracting kenitu peel by maceration using 70% ethanol, testing antioxidant activity using the DPPH method, and testing the antibacterial activity of kenitu peel extract against Staphylococcus aureus. The results of the antioxidant activity test showed an IC₅₀ value of 126.96 ppm. Antibacterial activity testing showed a MIC value of 250 ppm and a MBC value of 500 ppm. The conclusion of this study is that kenitu peel extract has moderate antioxidant activity and kenitu peel extract is able to inhibit the growth and kill Staphylococcus aureus bacteria.

The FORMULATION AND ACTIVITY TEST OF GEDI LEAF (Abelmoschus manihot L.) ANTI-ACNE GEL ETHANOL EXTRACT ON Staphylococcus aureus IN VITRO

Abdul Wahid Suleman — Tue, 14 Nov 2023 09:42:50 SE Asia Standard Time

Gedi leaves (Abelmoschus manihot L.) have compounds such as flavonoids, saponins, tannins, and terpenoids which are useful as antibacterials, such as the treatment of acne and other diseases. This research method was carried out in a laboratory experiment, namely gedi leaf extract was made in the form of a gel preparation with a concentration of negative control, FI (2.5%), FII (5%), FIII (7.5%) . Then proceed with the evaluation of the preparation with the organoleptic test, homogeneity test, pH test, spreadability test, adhesion test, viscosity test, and Cyling test. Antibacterial activity testing was carried out using the well method. The results of this study indicate that the ethanol extract of gedi leaves can be formulated as an anti-acne gel preparation that is physically and chemically stable. In the antibacterial test, the inhibition zone formed in formula 1 (2.5%) was 10,7±0,95 mm, in formula 2 (5%) the inhibition zone formed was 15,6±0,86 mm and in formula 3 (7.5%) was the concentration which has the most optimal antibacterial activity against Staphylococcus aureus bacteria with an inhibition zone area of 18,8±0,70 mm. Conclusion: Gedi leaf ethanol extract anti-acne gel preparation can inhibit Staphylococcus aureus bacteria most effective at a concentration of 7.5%, namely 18,8±0,70 mm

ANALISIS KANDUNGAN KAFEIN PADA MINUMAN KOPI SIAP SAJI MENGGUNAKAN METODE KROMATOGRAFI LAPIS TIPIS-GAMBAR DIGITAL

Ni Luh Ika Rahayu, M.A. Hanny Ferry Fernanda — Fri, 17 Nov 2023 10:45:49 SE Asia Standard Time

Caffeine is a colorless, crystalline powder that has a slightly bitter taste. One of them is ready-to-drink coffee, which can help increase concentration and is much loved. This study aimed to develop a semi-qualitative analysis of caffeine compounds in ready-to-drink coffee using the TLC method. The mobile phase used was methanol: ethyl acetate: acetic acid (3:1:6) with a saturation time of the mobile phase in the chamber of 20 minutes, and the stationary phase used silica gel 60 F254. The results obtained have a linearity (r) of 0,991413. As for the caffeine content in ready-to-drink coffee brand A was 99,37 mg; brand B was 144,81 mg, and brand C was 96,42 mg. It can be concluded that digital image processing using the semi-quantitative TLC method of ready-to-drink coffee contains positive caffeine compounds