Jurnal Penelitian Farmasi & Herbal

FORMULASI DAN UJI MUTU FISIK SEDIAAN GEL EKSTRAK BUNGA TELANG (Clitoria ternatea L.) SEBAGAI ANTISEPTIK TANGAN

Moh Farhan — Wed, 31 May 2023 09:44:24 SE Asia Daylight Time

Hands are one of the media for microbial growth, dirty hands become a breeding ground for microbes such as Staphylococcus aureus and Escherichia coli or other bacteria. How to maintain hand hygiene is to wash your hands with soap or use an antiseptic (hand sanitizer). Antiseptic preparations are substances that have been widely used to inhibit the growth and kill microorganisms that exist around the body surface, for example on the palms of the hands that often come into contact with the surface of an object. One of the natural ingredients that has the potential to be developed as a hand antiseptic is telang flower (Clitoria ternatea). This research will formulate antiseptic gel preparations from telang flower extract, and how to test the physical quality of antiseptic gel preparations from telang flower extract. The method used for the extraction process here uses the maceration method, to maintain the antimicrobial compounds contained in the telang flower, followed by testing the physical characteristics and quality of the telang flower gel preparation, including, Organoleptic Test, pH test, Viscosity test, Homogeneity test, Spreadability test, adhesion test. After testing the characteristics and physical quality of the gel preparations of telang flower extract, the results were quite optimal, namely with a pH value in the range of 4.26-4.41 according to skin pH, and for viscosity at a value of 64% - 33%, in accordance with the characteristics of a good gel. Telang flower extract can be made and formulated as an antiseptic hand gel preparation. Variations in the concentration of the extract used greatly affect the characteristics of the gel preparation, starting from pH, viscosity, adhesion, and dispersion. The higher the concentration of the extract used, the lower the viscosity value, and the lower the pH value. The pH value and viscosity value for all formulas were in accordance with the skin parameter criteria, namely 3.5-6.5. Based on research conducted, Formula 3 using a concentration of 0.5 has. the most optimal gel preparation

Keywords: Antioxidant, DPPH, Turmeric Instant Powder, UV-Vis Spectrophotometer and IC50 value.

muhammad alfian — Wed, 31 May 2023 09:45:10 SE Asia Daylight Time

Abstract

Turmeric and tamarind herbal medicine is one of the drinks with turmeric and tamarind as raw materials which is quite widely consumed by the community, either in liquid form or in powder form. Jamu turmeric acid can be used to prevent the negative effects of free radicals on the body because there are active antioxidant compounds, besides that it can be used as a natural antioxidant. There are many natural antioxidants in nature, one of which is in traditional medicine. The content of Jamu turmeric acid is curcuminoids where this compound is useful as an anti-inflammatory and antioxidant. This study aims to determine the antioxidant activity of instant turmeric powder drink produced by of UMKM Healthy Partners, Kiringan Bantul herbal tourism village, using the DPPH method (2,2-diphenyl-1-picrylhydrazyl). The absorbance measurement to determine the antioxidant activity of each sample of turmeric tamarind powder was tested using a UV-Vis spectrophotometer at a maximum wavelength of 516 nm. Determination of antioxidant activity by the DPPH method is expressed by the IC50 (Inhibiton Concentration 50) value. The results showed that the antioxidant activity of the instant turmeric powder drink (Curcuma domestica val.-tamarindus indica l.) produced by Mitra Sehat SME in the Jamu Kiringan Tourism Village, Bantul, was included in the very weak category with an IC50 value of each sample successively. The participants were sample A of (276.005 ppm), sample B of (265.434 ppm), and sample C of (256.183 ppm).

Keywords: Antioxidant, DPPH, Turmeric Instant Powder, UV-Vis Spectrophotometer and IC₅₀ value.

UJI EFEKTIVITAS SALEP EKSTRAK ETANOL DAUN SIRIH CINA (Peperomia pellucida) TERHADAP PENYEMBUHAN LUKA EKSISI PADA TIKUS PUTIH (Rattus norvegicus)

Rika Puspita Sari — Wed, 31 May 2023 09:45:29 SE Asia Daylight Time

ABSTRAK

Wahyuni. Test the effectiveness of Chinese betel leaf ethanol extract ointment on excision wound healing in white rats (Supervised by: apt.Rika Puspita Sari, S.farm.,M.Si )

Wounds are physical injuries that can cause tears and damage to skin tissue. One type of the wound is an excision wound. An excision of wound caused by the cutting of tissue by a sharp object. The main goal in wound management is to achieve rapid healing with optimal fuction and good result. That can be achieved by preventing infection and trauma by providing an environtment that optimizes wound healing. One of the plants that have the potential to heal wounds is the Chinese betel plant that have the potential to heal wounds is the Chinese betel plant the purpose of the research to determine the effectiveness of giving Chinese betel leaf extract on excision wound healing in white rats(rattus norvegicus). The research was conducted in the laboratory of health the husada deli tua.

The method of the research conducted out experimentally, the sample was extracted by the maceration method. And then the extract was formulated into ointment availability with concentrations of 2%,4%, and 8% furthermore, on evaluation of the availability of the ointment was carried out, by organoleptic test, homogeneity test, pH test and spreadability test.

The result of the research for each group gave the best treatment experienced a decrease in the diameter of the cut wound was the positive control group (povidone iodine) and 8% concentration. Conclusions: the ethanol extract of chial betel leaf has the effectiveness of healing excision wounds at a concentration of 8%

Keywords: Chinese betel leaf extract, excision wound

FORMULASI SEDIAAN SALEP KOMBINASI EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) DAN DAUN KERSEN (Muntingia calabura L.)TERHADAP PENYEMBUHAN LUKA TERBUKA PADA TIKUS JANTAN PUTIH TAHUN 2022

masria phetheresia sianipar — Wed, 31 May 2023 09:46:18 SE Asia Daylight Time

Background: Wounds are damage to part of body tissue or damage to tissue components, where there are damaged or missing tissue substances. Jackfruit leaves (Artocarpus heterophyllus Lam.) contain secondary metabolites, namely, flavonoids, saponins and tannins. Flavonoids function as antibacterial and reduce inflammation in wounds. Saponins to trigger the formation of collagen. While the tannins function as an antibacterial.

Cherry leaves (Muntingia calabura L.) contain several active compounds such as flavonoids, saponins, and tannins. Compounds that function as anti-inflammatory are flavonoids. These compounds can accelerate wound healing because it has anti-inflammatory activity.

Objective: to determine the concentration of the combination ointment of jackfruit leaf and cherry leaf ethanol extract in the form of an ointment that is most effective in healing open wounds. Method : Experimentally. Samples using jackfruit and cherry leaves were taken purposively, extracted by maceration using 96% ethanol as a solvent made in the form of a thick extract. Then the thick extract was made into an ointment with a ratio of 1:2, 2:1 and 2:2 as well as positive control (bacitracin ointment), negative control (ointment base). open wound for 14 days. Results: The results of the open wound healing study had the best effectiveness, namely bacitracin ointment (0 cm), a combination ointment of jackfruit leaf and cherry ethanol extract 2:2 (0.10 cm), 1:2 (0.25 cm) and 2 :1 (0.28 cm) then ointment base (0.55 cm). Conclusion : The preparation of ointment combination of jackfruit leaf ethanol extract and 2:2 cherry is more effective in the treatment of open wounds.

U UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL HAND SANITIZER SANITIZER BUNGA LAWANG (Illiacium verum Hook. f) pada BAKTERI Staphylococcus aureus & Escherichia coli

Novarianti Marbun — Wed, 31 May 2023 09:46:40 SE Asia Daylight Time

Some diseases caused by microorganisms on the hands are diarrhea, diphteria, boils, typhus and others. The bacteria that most often contaminate the skin of the hands are Staphylococcus aureus and Escheria coli, whose spreas most often transmitted from hand to hand. Bunga lawing are one of the medicinal plants that have been used in medicine. The purpose of this study was determine the antibacterial activity of gel hand essential oil sanitizer gel preparation (Illiacium verum Hook.f) to the growth of Staphylococcus aureus and Escheria coli bacteria compared to sanitizer Dettol gel hand. This was carried out with the experimental method. Essential oil of bunga lawing is extracted using a heat method, namely soxhletation. The antibacterial activity test in this study used the agar diffusion method (disc diffusion). The measurement of the diameter of the inhibited area formed were analyzed using a one-way ANOVA statistical test. The results of antibacterial activity of bunga lawang sanitizer hand have lower antibacterial activity gel hand sanitizer Dettol. In the diameter of Staphylococcus aureus bacteria the highest rate 0f hand flower sanitizer gel was 15,1 mm while the sanitizer gel hand wash 21,4 mm. In Escheria coli bacteria, the inhibitory diameter the sanitizer hand gel dettol was obtained at 20.1 mm, while the lawang hand
sanitizer gel obtained the highest inhibition diameter of 13.1 mm. The results of data analysis using a one-way ANOVA statistical test showed a sig value p<0,05 so that there were significant differences between the gel hand to the inhibitory power of the growth of Staphylococcus aureus and Escheria coli bacteria.

PENETAPAN KADAR VITAMIN C DAN FORMULASI SEDIAAN GRANUL INSTAN EKSTRAK KULIT JERUK KEPROK (Citrus reticulate Blanco.)

Framesti Frisma Sriarumtias, Raden Aldizal Mahendra Rizkio Syamsudin — Wed, 31 May 2023 09:47:17 SE Asia Daylight Time

Tangerines (Citrus reticulata Blanco.) is one of the national superior types of oranges that contain lots of vitamin C. Vitamin C is the simplest vitamin and has an important role on the human body. So far the use of arrowroot is only on the fruit, while the peel is only a waste. The purpose of this study is to utilize tangerine peels into preparations that have a use value for the community, in the form of instant granules. The method used in the extraction of tangerine peel is maceration by making granules using the wet granulation method, and determination of vitamin C levels by quantitative methods, UV-Vis spectrophotometry method. After obtaining the vitamin C levels, then formulations are made in the form of instant granules and quality evaluations are carried out. The results showed that vitamin C content was 130 mg / 1250 mg extract and the formula was made with the best formula, Formula 1.

Potensi Ekstrak Etanol Biji Bunga Telang (C.ternatea L.) sebagai Agen Antihiperlipidaemia (Studi In Silico)

Atik Kurniawati, Nur Rahman Nur Rahman, Dwipajati Dwipajati — Wed, 31 May 2023 09:47:32 SE Asia Daylight Time

Hiperlipidemaemia didalam tubuh ditandai dengan meningkatnya kadar kolesterol didalam darah. Dibutuhkan hambatan kompetitif terhadap HMG-CoA reduktase.Senyawa dari tanaman herbal bunga telang (Clitorea ternatea L.) berpotensi sebagai agen antihiperlipidaemia. Tujuan penelitian ini adalah untuk mengetahui potensi biji bunga telang (C. ternatea L.) sebagai agen antihiperlipidemia melalui studi in silico. Persiapan ligand dengan reseptor menggunakan software YASARA. Moleculer docking menggunakan software PLANTS. Visualisasi menggunakan LigPlus dan PyMol. Reseptor yang digunakan adalah struktur kristal HMG-CoA reduktase dengan kode PDB 1HW9 dan ligand kontrol simvastatin.Hasil penelitian menunjukkan senyawa phloretin, trifolin dan trigonelline yang diprediksi memberikan efek antihiperlidemia berdasarkan studi in silico karena memiliki interaksi masing-masing secara berurutan yaitu phloretin (-64,05), trifolin (-59,24) dan trigonelline (-52,76). Residu asam amino yang berperan dalam ikatan ligand dengan reseptor adalah Asp 767, Tyr 761, Ala 768, Asn 771, Glu 801, Gln 770, Ser 774, Met 655, Ile 802, Gln 766.

Pengaruh Metode Pengeringan Ekstrak Daun Kelor (Moringa oleifera Lam) Terhadap Aktivitas Antioksidan

Adinda Putri Pertiwi — Wed, 31 May 2023 09:47:45 SE Asia Daylight Time

Daun kelor adalah salah satu tumbuhan yang sudah dimanfaatkan masyarakat dalam pengobatan tradisional. Tumbuhan kelor banyak mengandung berbagai molekul penghambat radikal bebas, seperti aktivitas antioksidan. Pembuatan simplisia daun kelor dilakukan dengan pengeringan menggunakan oven pada suhu 40⁰C dan sinar matahari langsung. Simplisia yang terbentuk dimaserasi dalam pelarut etanol 70%. Pengukuran aktivitas antioksidan ekstrak menggunakan metode DPPH dengan Spektrofotometer UV-Vis pada panjang gelombang 516,50 nm. Hasil penelitian memperlihatkan bahwa daun kelor yang dikeringkan dengan oven pada suhu 40°C memiliki aktivitas antioksidan nilai IC₅₀ 67,75 ppm dengan kategori antioksidan kuat dan ikeringkan di bawah sinar matahari memiliki nilai IC₅₀ 122,34 ppm dengan kategori antioksidan sedang. Dari penelitian ini adalah aktivitas antioksidan ekstrak daun kelor dengan metode pengeringan oven lebih tinggi dari metode pengeringan sinar matahari langsung.

UJI STABILITAS FISIK FORMULASI SEDIAAN HAIR TONIC HERBAL BUAH MENTIMUN (Cucumis Sativus L) SEBAGAI PERAWATAN RAMBUT

Komang Tri Musthika, Putu Indra Cyntia Dewi — Wed, 31 May 2023 09:48:43 SE Asia Daylight Time

Hair is an essential part of the body that often experiences various problems, one of which is hair loss. Fortunately, hair loss problems can be prevented by applying a hair tonic. Many hair tonic preparations are on the market, both made from herbal and synthetic ingredients. Efforts have been made to formulate cucumber into hair tonics. This study aims to utilize herbal plants, particularly cucumber, as a remedy for hair loss. Cucumber was developed into several hair tonic formulations, and their physical stability was subsequently tested. The cucumber was extracted using the infusion method. The yielded infusion was later made into three formulas of hair tonics with three times replications for each procedure. Following the formulations, physical stability tests of the preparations were carried out, such as organoleptic, homogeneity, pH, and viscosity tests. Results of the tests showed that the trials were physically stable with a homogenous physical appearance indicating an even distribution of cucumber extract in the preparations. Further results showed average pH of 5.87, 6.12, and 6.49 with viscosity values of 0.0082, 0.0083, and 0.0085 N.S/m2, respectively. In conclusion, all the ingredients in the formulation of herbal hair tonics provided stable color and pH range that still met the requirements. Hence, this study suggested the administration of cucumber hair tonic as one of many remedies for hair ailments, specifically hair loss.

EVALUASI PELAYANAN INFORMASI OBAT PASIEN RAWAT JALAN DI PUSKESMAS KARTASURA KABUPATEN SUKOHARJO JAWA TENGAH

Riska Chandra Pradana — Wed, 31 May 2023 09:48:59 SE Asia Daylight Time

Pharmaceutical services at the public health center play an important role in the implementation of efforts to improve public health, one of which is the provision of drug information services to support drug use with the aim of successful treatment. The objective of this study was to assess outpatient drug information services at the Kartasura Health Center. This type of research is a descriptive observational research that is quantitative in nature using a questionnaire sheet of 96 respondents. Kartasura Public Health Center related to the provision of drug information to outpatients has been carried out, but there is still drug information that has not been conveyed by pharmacists or 0% is not conveyed, namely stability and contraindications. The drug information points that were transmitted to the specific drug are the drug name at 100%, the dosage form at 100%, the drug dose at 100%, the method of use at 98.96%, and the indications at 97.92%. The drug information points that were submitted, but only for some drugs, were storage rules at 86%, side effects at 57%, and interactions at 19%.

REVIEW : TANAMAN YANG BERKHASIAT MENURUNKAN ANTIHIPERTENSI

Chandra Muhammad — Wed, 31 May 2023 09:52:34 SE Asia Daylight Time

Hipertensi merupakan peningkatan tekanan darah yang tidak normal, baik itu tekanan darah sistolik (TDS) maupun tekanan darah diastolik (TDD) yang menjadi salah satu penyebab kematian terbanyak di dunia. Pasien dapat dikatakan menderita hipertensi apabila memiliki tekanan darah sistolik/diastolik lebih dari 140/90 mmHg. Tanaman tradisional memiliki berbagai kandungan kimia yang dapat dimanfaatkan sebagai pengobatan alternatif untuk menurunkan tekanan darah. Artikel ini bertujuan untuk mengetahui beberapa tanaman tradisional yang mamp dimanfaatkan untuk menurunkan tekanan darah. Artikel ini disusun dengan mencari data acuan dalam beberapa jurnal yang tersedia pada situs internet. Beberapa tanaman yang ditemukan memiliki aktivitas sebagai agen antihipertensi adalah Apium graveolens, Persea americana, Morinda citrifolia, Mangifera indica, dan Averrhoa bilimbi.

Aktivitas Antipiretik Pada Senyawa Berkhasiat Dari Berbagai Tanaman Obat

Khafifah Nanda Permata Sari — Wed, 31 May 2023 09:53:22 SE Asia Daylight Time

Indonesia is one of the largest countries for medicinal plants in the world, various types of plants in Indonesia are used in generations. parts that are often used are roots, wood, leaves, fruit and seeds in fever medicine plants, there is an increase in body temperature that is directly related to the lithogenic sitokin level used to overcome various stimuli. antipyretic drugs are drugs used to overcome fever. The purpose of this article is made to find out which medicinal plants can be used as fever reducers. The method used is literature searches from national and international journals. From the results obtained by papaya plants (Carica papaya L.), turmeric (Curcuma longa Linn.), pepper (Piper nigrum L.), pare (Momocardica charantia), and starfruit (Averrhoa blimbi L.) has an active compound that can play an antipyretic drug

UJI TOKSISITAS EKSTRAK ETANOL DAUN KELAPA (Cocos nucifera L.) SEBAGAI KANDIDAT ANTITUMOR DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT)

Tuhfatul Ulya, Musparlin Halid — Wed, 31 May 2023 09:53:40 SE Asia Daylight Time

Tumor merupakan penyakit yang ditandai dengan adanya pembelahan sel yang tidak terkendali. Saat ini, terapi pembedahan dan radioterapi adalah pengobatan tumor yang paling efektif, tetapi tidak efisien ketika sel tumor telah menyebar ke seluruh tubuh (metastasis). Kemoterapi merupakan terapi pilihan untuk sel tumor yang bermetastasis, namun kemoterapi memiliki kelemahan karena tidak hanya mempengaruhi sel tumor, tetapi juga sel sehat yang membelah dengan cepat. Kelapa (Cocos nucifera) merupakan komoditas perkebunan yang potensial karena hampir semua bagian tanamannya dapat dimanfaatkan, tak terkecuali daun kelapa. Namun belum banyak penelitian yang melihat kebermanfaatannya dalam kesehatan. Penelitian ini diawali dengan skrining fitokimia ekstrak etanol daun kelapa. Uji toksisitas dilakukan dengan metode BSLT menggunakan 750 ekor larva Artemia salina yang terbagi dalam 6 kelompok (5 kelompok perlakuan dan 1 kelompok kontrol negatif), dengan konsentrasi ekstrak masing-masing kelompok perlakuan 1000, 500, 250, 125, dan 50 ppm, selanjutnya persen mortalitas larva Artemia salina dihitung setelah 24 jam paparan. Skrining fitokimia ekstrak etanol daun kelapa menunjukkan hasil positif adanya senyawa alkaloid, flavonoid, fenol, dan triterpenoid. Hasil uji toksisitas menunjukkan ekstrak etanol daun kelapa konsentrasi 1000, 500, 250, 125, dan 50 ppm mengakibatkan kematian pada larva Artemia salina. Persen mortalitas tertinggi ditemukan pada konsentrasi ekstrak 1000 ppm (41,33%). Nilai LC₅₀yang didapatkan sebesar 1621,05 ppm menunjukkan ekstrak etanol daun kelapa tidak cukup toksik untuk berpotensi sebagai kandidat antitumor dan antikanker.

ANALISIS NILAI SPF PADA PRODUK TABIR SURYA MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS

Ninis Yuliati, Silvia Putri Agustini, Fery Eko Pujiono, Tri Ana Mulyati — Wed, 31 May 2023 09:54:07 SE Asia Daylight Time

Indonesia is a country with high sun exposure and the potential for high sun exposure. These rays are UVA (290-320) and UVB (320-400) rays which have both good and bad effects on humans. The formation of Vitamin D and provitamin D is a benefit, but with severe ozone depletion the UV rays produced can be harmful to human health and can cause cancer. Sunscreen which is used to protect the health of human skin from the negative effects of solar radiation and can absorb light exposure is often used in daily life as a cosmetic whose effectiveness in light absorption is based on the value of the sun protection factor (SPF), hereby to determine the value and category SPF value on sunscreen products with UV-Vis Spectrophotometry method to find out its effectiveness. By using the sampling method of Non Probability Sampling. In the determination, mixing 3 samples of sunscreen, the determination of this SPF value is a measure of the protection of sunscreen cream preparations against Ultraviolet rays. The higher the SPF value, the greater the protective effect against sunburn. The results obtained deviation of 1.04 with an average SPF in this study was 4.1 which was included in the SPF category with minimal protection.

SYSTEMATIC REVIEW : UJI AKTIVITAS ANTI BAKTERI EKSTRAK BUAH ANDALIMAN (ZANTHOXYLUM sp)

Amirah Nahdiah Batubara, Saiful Batubara; Afrilius Simanjuntak — Wed, 31 May 2023 09:54:44 SE Asia Daylight Time

One type of spice whose utilization is still very limited is andaliman (Zanthoxylum sp), the Rutaceae tribe which is a typical Batak cooking spice. This study uses a systematic review method. The data used in this study are from research results that have been published in national and international journals. The results of a search for journal publications related to Andaliman Antibacterial Activity (Zanthoxylum sp) for the first phase of the 2012-2022 publication period obtained 34 domestic and foreign journal publications. After conducting a review based on the criteria, 14 journals were selected, 6 Indonesian language journals and 8 English language journals. 24 journals were excluded because they did not meet the criteria. The disc diffusion method is the most widely used method. S aureus and E.coli most dominant of data on Minimum Inhibitory Concentration (MIC) related to the antibacterial effect of andaliman (Zanthoxylum sp).

Analisis Tingkat Pemahaman Mahasiswa Jurusan Kesehatan UMS Terkait Penggunaan Obat Bebas dan Obat Bebas Terbatas Untuk Swamedikasi

Wed, 31 May 2023 09:55:13 SE Asia Daylight Time

Self medication is an effort to carry out treatment independently. The implementation of self medication must be based on knowledge about self medication itself, one of which is regarding the use of over the counter and limited over the counter drugs. Students majoring in health as potential to be health workers must have a good level of understanding regarding the use of over the counter and limited over the counter drugs in order to provide education to the general public so it can reduce the risk o medication error. The study was conducted using a cross sectional method by collecting primary data from the result of a questionnaire which was then filled out by 78 respondents who were the students majoring in health at the Muhammadiyah University of Surakarta. The research instrument used was tested for its validity and realibility using the SPSS version 16.0 program. From the validity and reliability tests, 10 questions were valid and the insrument used were reliable. Based on the research conducted, it was found that students majoring in health at the Muhammadiyah University of Surakarta have a sufficient level of understanding regarding to the use of over the counter and limited over the counter drugs for self medication with an average score of 68,08.

PEMANFAATAN LIMBAH KULIT JERUK NIPIS (Citrus aurantifolia) DAN SERBUK KOPI ARABIKA (Coffea sp) DALAM FORMULASI PEMBUATAN LULUR TRADISIONAL TAHUN 2022

sulasmi sulasmi — Wed, 31 May 2023 09:55:38 SE Asia Daylight Time

Lime peel and coffee grounds are good natural ingredients and have the potential to be used as cosmetic preparations, one of which is used to make body lulur preparations because lime peel contains vitamin C which can absorbs oil from the skin and removes dead skin cells so that the skin looks cleaner, softer and brighter, while the brewed coffee grounds have antioxidant activity, which contains 3.88% of antioxidants and 1-1.5% of caffeine contained in coffee grounds. This study aims to determine which lime peel and coffee grounds can lighten the skin in 2 weeks and to find out which formulation is the best. The lulur acceptability test includes a softness test, iritation test, ease of cleaning and skin brightness. then the lulur was tested for acceptability during week 0 to week 2. Based on the graph, formulation I with a concentration of 5%:10%, formulation II with a concentration of 10%:5% and formulation III with a concentration of 10%:10% are significant formulas for brightening the skin of some respondents. So it can be concluded that there is an effect of skin tone on the use of body lulur preparations at room temperature during week 0 to week 2.

PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN SALAM ( SYZYGIUM POLYANTHUM WIGHT) TERHADAP KADAR GLUKOSA DARAH PADA MENCIT PUTIH YANG DI INDUKSI ALOKSAN

Linta Meliala — Wed, 31 May 2023 09:55:56 SE Asia Daylight Time

Effect of Ethanol Extract of Bay Leaf (Syzygium polyanthum Wight.) Against Blood Glucose Levels In Alloxan Induced White Mice. Thesis, Department of Pharmacy, Faculty of Pharmacy, Deli Husada Deli Tua Health Institute. (Supervised by: apt. Linta Meliala, S.Si.,M.Si.) Diabetes mellitus (DM) is a metabolic disorder which is characterized by an increase in blood glucose levels. Obesity and overweight are risk factors for type 2 diabetes (WHO, 2019). One of the non-pharmacological drugs that can be used for diabetes mellitus is bay leaf. Bay leaves (Eugenia polyantha) are spread in various areas, both in the mountains and in the lowlands. To determine the antidiabetic activity of the ethanolic extract of bay leaf (Syzygium polyanthum Wight.) in alloxan-induced mice compared with glibenclamide.Experimental study using 25 mice induced with alloxan and divided into 5 groups. Group 1 (negative control) CMC Na 0.5%, group 2 (positive control) Glibenclamide dose 0.0026 mg/kgBW, group 3 bay leaf extract at 250 mg/kgBW, group 4 bay leaf extract at 500 mg/kgBW, group 5 bay leaf extract dose of 750 mg/kgBW. Extraction using maceration method with 96% ethanol as solvent. From the results of the study, each treatment group experienced a decrease in blood glucose levels. Of the 5 treatment groups, the best reduction in blood glucose levels was glibenclamide. The positive control of glibenclamide produced a faster reduction effect than the ethanolic extract of bay leaf. The greatest effectiveness in the ethanol extract of bay leaf 750 mg/kgBW with a faster decrease in blood glucose levels was almost equivalent to the positive control. Ethanol extract of bay leaf (Syzygium polyanthum) can reduce blood glucose levels in male white mice induced with alloxan

STUDI ETNOBOTANI TANAMAN OBAT SEBAGAI PENCEGAH STUNTING OLEH MASYARAKAT WALI NAGARI SIJUNJUNG KABUPATEN SIJUNJUNG, SUMATERA BARAT

Relin Yesika — Wed, 31 May 2023 09:56:10 SE Asia Daylight Time

Stunting is the impaired growth and development that children experience from poor nutrition, repeated infection, and inadequate psychosocial stimulation. Children are defined as stunted if their height-for-age is more than two standard deviations below the WHO Child Growth Standards median. Malnutrition that occurs during pregnancy can lead to stunting which usually appears after the baby is 2 years old. One of the efforts to prevent stunting is consuming a balanced nutritious diet. Many plants and herbs have good nutritional value that can prevent stunting. Plants that have nutritional value can be processed into food that can prevent stunting. This research is a qualitative descriptive method, research has been carried out with the stages of compiling research objectives, observations, interviews, documentation. This research was carried out to answer the need for information related to plant data used to prevent stunting by the community in Wali Nagari, Sijunjung Regency, West sumatera. There were 41 residents in Wali nagari as respondents. The plants most commonly used by the community in Wali Nagari as stunting prevention plants are cassava leaves, spinach leaves, legumes or nuts, katuk leaves, aromatic ginger, kelor leaves, temulawak, pegagan or gotu kola leaves, etc

FORMULASI DAN UJI EFEKTIVITAS SEDIAAN KRIM EKSTRAK DAUN KELOR (Moringaoleifera) TERHADAP PENYEMBUHAN LUKA BAKAR PADA TIKUS PUTIH JANTAN (Rattus novergicus)

Rani Ardiani — Wed, 31 May 2023 09:56:29 SE Asia Daylight Time

Burns are iinjuries ito ithe iskin ior iother iorganic itissue imainly icaused iby iheat ior idue ito iradiation, ifriction ior icontact iwith ichemicals. i iOne iof ithe iplants ithat ihave ithe ipotential ias ia iburn itreatment iis iMoringa ileaves. i iIn iMoringa i(Moringaoleifera) ileaves, iflavonoid ichemical icompounds ican iact idirectly ias iantibiotics iby iinterfering iwith ithe ifunction iof imicroorganisms isuch ias iburns. Objective to idetermine ithe imost ieffective iconcentration iof iMoringa i(Moringaoleifera) ileaf iethanol iextract ifor ihealing iburns iin imale iwhite irats. Methodirats ithat ihave ibeen ianesthetized iwith ilidocaine imuscularly. i Wounds iin rats iwere imade iby iattaching ia iheated i1 ix i1 icm istainless iplate. i iOn ithe ibacks iof irats iwhose ifur ihas ibeen ishaved iand iaffixed ito ithe iplate ifor i30 iseconds ito iform iblisters ior iburns, ithen ithe ipositive icontrol iconcentration igroup iis iapplied iwith ibioplacenton, ithe inegative icontrol iis ismeared iwith icream ibase, iand ithe itest igroup iis ismeared iwith iconcentrated iMoringa ileaf iextract icream i5%, i10% iand i.15%. i iThe ismearing iof iall itreatment igroups iwas icarried iout ievenly i3 itimes ievery iday, iobserving ichanges iin iburns ifor i14 idays. \

Results ithere iwas ia ireduction iin iburn ilength iat ieach iconcentration. i iThe ipositive icontrol ishowed ithe ifastest ireduction ievery iday ibecause iit icontained placenta extract and neomycin sulfate, in the negative control the wound healing was quite long from the wound diameter because it only used a cream base that did not contain nutritious substances. And at a concentration of 15% faster in the wound healing process. Conclusion:Moringa leaf ethanol extract at a concentration of 15% was the most effective in healing burns in male white rats compared to concentrations of 5% and 10%.

FORMULASI SEDIAAN GEL EKSTRAK ETANOL UMBI DAHLIA ( Dahlia variabilis )TERHADAP PERTUMBUHAN BAKTERI Stapylococcus aureus PENYEBAB INFEKSI KULIT

Zola Efa Harnis — Wed, 31 May 2023 09:56:49 SE Asia Daylight Time

Dahlia tubers (Dahlia variabilis) are plants that are often found in the higglands. The content in Dahlia tubers is able to inhibit microbial growth. The compound content of Dahlia tubers includes alkaloids, flavaanoids, sapnonins and tannins. One of the diseases caused by microbes is a skin infection. The purpose of this study was to make a gel preparation from the ethanolic extract of dahlia bulbs and to test whether the formulation was able to inhibit the growth of Stapylococcus aureus bacteria at concentrations of 4%, 6% and 8%. The extraction used in this research is the maceration method with 96% ethanol as solvent. Evaluation test of gel preparations and antibacterial activity test by discdiffusion method. Then the one way ANOVA test was carried out. The results showed different result in each formulation. Based on the average results of the antibacterial activity test, the inhibition zones of F) were 17,0 mm, F1 18,13 mm, F2 was 19,73 mm, and F3 8,23 mm. The results of this study conuluded that the extraction of Dahlia tubers had antibacterial activity due to the presence of an inhibitory zone around the paper disc in a petri dish. Further research needs to be done with other methods.

PENENTUAN KANDUNGAN ANTIOKSIDAN DAN FENOLIK TOTAL DARI EKSTRAK TUMBUHAN SEBAGAI BIOREDUKTOR DALAM PEMBENTUKAN NANOPARTIKEL PERAK

Dini Hanifa, Refilda Refilda, Akmal Djamaan — Wed, 31 May 2023 09:57:04 SE Asia Daylight Time

The formation of metal nanoparticles (silver, gold, platinum) by biological methods (green synthesis) has advantages over chemical and physical methods because it is easier, faster, simpler, and environmentally friendly. One of the substances used in this method is plant extracts. The presence of secondary metabolites that act as antioxidants such as phenolics and flavonoids play roles in the formation of silver nanoparticles. In this study, phytochemical screening was carried out from several herbal plants as bioreductors in the formation of silver nanoparticles, such as Phyllanthus buxifolius, Pachira aquatica, Peperomia pellucida, Ageratum conyzoides, and Piper crocatum leaf extracts. The total antioxidant content was determined using the modified phenanthroline method, and the total phenolic content determined using the Folin-Ciocalteu method. The formation of silver nanoparticles was carried out by mixing silver nitrate solution with each plant extract. Colloidal silver nanoparticles formed were then measured for their absorption spectra. The results of the antioxidant content of the five consecutive samples were 26,90 ± 0,19; 26,09 ± 0,14; 18,25 ± 0,02; 42,76 ± 0,14; dan 30,94 ± 0,14 mg AA/g, while the total phenolic contents were 48,44 ± 0,45; 21,08 ± 0,92; 17,42 ± 0,27; 57,71 ± 0,47; dan 49,83 ± 0,60 mg GA/g. Silver nanoparticles mediated by Ageratum conyzoides leaf extracts provided the highest absorbance value compared to other plants. The antioxidants and phenolic contained in the extract acts as reducing agent from silver ions into silver nanoparticles.