http://ejournal.delihusada.ac.id/index.php/JPFH/issue/feed Jurnal Penelitian Farmasi & Herbal 2021-01-17T18:22:34SE Asia Standard Time dr. Muhammad Agung Prawira, MKM agngprwr@gmail.com Open Journal Systems <div style="text-align: justify;"> <p>Jurnal Penelitian Farmasi &amp; Herbal memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat, serta artikel ilmiah di bidang farmasi dan herbal. Artikel penelitian dan pengabdian masyarakat yang dimuat dlam jurnal ini merupakan topik penting dalam pengembangan ilmu pengetahuan di bidang farmasi dan herbal, membantu pemecahan masalah seputar kefarmasian dan membantu meningkatkan kualitas hidup manusia. Jurnal Penelitian Farmasi &amp; Herbal &nbsp;bersifat independen, ilmiah, memberi kesempatan yang sama kepada akademisi dari berbagai jenjang dan asal pendidikan tinggi.</p> </div> http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/306 Uji Efektivitas GELL Obat Jerawat Dari Ekstrak Etanol Buah Pare (Momordica charantia L.) Terhadap Pertumbuhan Bakteri Propionibacterium acnes 2021-01-17T18:22:34SE Asia Standard Time herviani sari sari.herviani21@gmail.com Firdaus Fahdi daus2966@gmail.com <p><em>Bacterial infection is a major factor in causing acne. The causes of acne are many (multifactorial), including genetic, endocrine, dietary factors, the activity of the sebaceous glands themselves, psychological factors, mucin, infection by Propionibacterium acne, cosmetics, and other chemicals. Pare extract can be formulated as a gell pimple, which can inhibit the growth of propionibacterium acne. The samples in this study were gell preparations of the ethanol extract of bitter melon with a concentration of 5%, 7.5%, 10%. Based on the results obtained, the addition of the ethanol extract concentration of bitter melon fruit depends on the extract produced. The higher the concentration of gell preparations, the better it is to inhibit bacterial growth. The &nbsp;results showing that pare fruit extract with a concetration of 5%, 7,5%, 10%, and as gell verile 0,025% get a variety of results. And a good resistance zone on the three concentrations that are most close to verile effectiveness is 10% concentration. In conclusion, bitter melon extract can be formulated as an acne medication that can inhibit the growth of the Propionibacterium acnes bacteria.</em></p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/307 UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN MELINJO (Gnetum gnemon L.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus dan Streptococcus mutans TAHUN 2020 2021-01-17T18:22:31SE Asia Standard Time Firdaus Fahdi daus2966@gmail.com Herviani Sari herviani.sari10@gmail.com <p>The&nbsp;<em><span data-preserver-spaces="true">Gnetum gnemon</span></em><span data-preserver-spaces="true">&nbsp;can be used as a medicine that has the function of anti-bacterial. The chemical content inside which is anti-bacterial is flavonoids and tannins. This study aims to find out the antibacterial from the ethanol extract of melinjo leaves can inhibit the growth of&nbsp;</span><em><span data-preserver-spaces="true">Staphylococcus aureus</span></em><span data-preserver-spaces="true">&nbsp;and&nbsp;</span><em><span data-preserver-spaces="true">Streptococcus mutans</span></em><span data-preserver-spaces="true">&nbsp;with a concentration of 300 mg/ml, 400 mg/ml, and 500 mg/ml. The test of anti-bacterial activity for the growth&nbsp;</span><em><span data-preserver-spaces="true">Staphylococcus aureus</span></em><span data-preserver-spaces="true">&nbsp;and&nbsp;</span><em><span data-preserver-spaces="true">Streptococcus mutans</span></em><span data-preserver-spaces="true">&nbsp;is done by using the disc diffusion method. The results showed that melinjo leaf contains an alkaloid, flavonoid, tannin, steroid and saponin compounds. The results of the simplicia powder characteristics obtained a total ash content of 7.495%, ash content insoluble in acid 0.785%, ethanol-soluble extract 4.324%, water-soluble extract 17.690%. The results of the antibacterial activity test of the ethanol extract of melinjo leaves obtained can inhibit the growth of&nbsp;</span><em><span data-preserver-spaces="true">Staphylococcus aureus</span></em><span data-preserver-spaces="true">&nbsp;and&nbsp;</span><em><span data-preserver-spaces="true">Streptococcus mutans</span></em><span data-preserver-spaces="true">&nbsp;namely at a concentration of 300 mg/ml, 400 mg/ml, and 500 mg/ml into the medium inhibition zone category. Ethanol extract of melinjo leaves has antibacterial activity against the growth of&nbsp;</span><em><span data-preserver-spaces="true">Staphylococcus aureus</span></em><span data-preserver-spaces="true">&nbsp;and&nbsp;</span><em><span data-preserver-spaces="true">Streptococcus mutans</span></em><span data-preserver-spaces="true">&nbsp;with an average diameter of inhibition zone of 9.7 mm (medium category) against&nbsp;</span><em><span data-preserver-spaces="true">Staphylococcus aureus</span></em><span data-preserver-spaces="true">&nbsp;and 6.7 mm (medium category) against bacteria&nbsp;</span><em><span data-preserver-spaces="true">Streptococcus mutans</span></em><span data-preserver-spaces="true">.</span></p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/310 UJI EFEKTIVITAS SALEP EKSTRAK ETANOL RIMPANG JERINGAU (Acorus calamus L.) TERHADAP PENYEMBUHAN LUKA SAYAT 2021-01-17T18:22:28SE Asia Standard Time Linta Meliala lintameliala@gmail.com <p><strong><em>Introduction:</em></strong><em> Jeringau rhizome plants are one of the traditional plants which are used as antibacterial.<strong> Method:</strong> The extraction process was carried out by maceration using 80% ethanol. The effectiveness of jeringau rhizome testing was divided into 5 treatments, the positive group used betadine ointment, negative control using an ointment base, and the test group used ethanol extract ointment with 5%, 10% and 15% concentration. Cut wounds given to the rabbit's back with a 2 cm long wound and 2 mm deep, the ointment applied twice a day for 13 days and measured using a ruler or calipers. <strong>Result:</strong> The results show that Jeringau rhizome contains flavonoid, tannin, saponin, and alkaloid metabolites which can be used as wound heal wound healers. This study aims to determine its effectiveness as a wound healer wound. <strong>Conclusions:</strong> indicate that the ointment extract jeringau rhizome at a concentration of 15% is the most effective control as a wound healer but the ointment extract of jeringau rhizome ethanol extract is less effective when compared to betadine ointment as a wound healer in rabbits. .</em></p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/313 PENETAPAN KADAR KAFEIN PADA BUBUK TEH HITAM YANG BEREDAR DI PASAR DELI TUA MENGGUNAKAN SPEKTROFOTOMETRI UV 2021-01-17T18:22:24SE Asia Standard Time DIAN IKA PERBINA MELIALA dianikaperbinameliala@gmail.com <p><em>Tea is a drink that is very familiar in the world and is very common in everyday life. Tea is also the most consumed and favored beverage by the public after water. Besides being beneficial, tea also contains compounds that have a negative impact on the body, namely caffeine compounds. Caffeine is an alkaloid of the methylxanthine group which plays a role in increasing the work of psychomotor in the body, and side effects that can be caused are anxiety, irregular heartbeat, difficulty sleeping, tremors, diuresis and others. The purpose of this study was to determine the caffeine content in black tea powder circulating in the Old Deli market. This type of research is descriptive with a purposive sampling method. The analytical method used is qualitative with murexide and quantitative ultraviolet spectrophotometry with a wavelength of 267nm. The results of a qualitative analysis of all positive samples contained caffeine. The average quantitative yield of caffeine in brand A black tea powder was </em><em>(4,82 ±0,0356)%, B brand black tea powder (4,89 ± 0,0173)% and C brand black tea powder (4,93 ± 0,0531)%. The validation test results obtained linearity r = 0,9984, LOD and LOQ is 0,8074 mcg/ml and 2,6914 mcg/ml ,% recovery = 100,07%, RSD = 0,33%. Based on the results of research conducted, it can be concluded that ultraviolet spectrophotometry can be used to determine caffeine levels in black tea powder.</em></p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/315 EFEKTIVITAS EKSTRAK ETANOL DAUN EFEKTIVITAS EKSTRAK ETANOL DAUN SIDAGURI (Sida rhombifolia L.) TERHADAP PENURUNAN KADAR ASAM URAT PADA TIKUS JANTAN GALUR WISTAR HIPERURISEMIA 2021-01-17T18:22:21SE Asia Standard Time Bunga Rimta Barus ellalimbeng@gmail.com <p><em>Sidaguri</em><em> leaves (</em><em>Sida rhombifolia L.</em><em>) Have been shown to contain flavonoid compounds, where they are efficacious as hyperuricemia. This study aims to determine effectiveness ethanol extract of sidaguri leaves as antihyperuricemia in white rats. The study was conducted using the method of potassium oxanate induction and measured using glucometers. 15 animals were divided into 5 groups, namely negative control, positive control, group I combination of ethanol extract of sidaguri leaves 50 mg / kg body weight, group II ethanol extract of sidaguri leaves 100 mg / kg body weight, group III ethanol extract of sidaguri leaves 200 mg / kg body weight for 5 hours. Examination of antihyperuricemia effects is done by comparing the uric acid levels value of the rats before and after treatment. The results of this study indicate that the three dose ethanol extract of sidaguri leaves provide an antihyperuricemia effect and based on one-way Anova, Tuckey and LSD data analysis, shows that the dose of 50 mg / kg body weight is effective as antihyperuricemia and does not have a significant difference (p&gt; 0.05). The conclusion of this study is that the dose is the most effective in </em><em>decreases uric acid</em><em> levels in white rats, which is a dose of 200 mg / kg body weight because it mostly decreased uric acid levels.</em></p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/316 FORMULASI OBAT KUMUR GAMBIR DAN UJI EFEKTIVITAS TERHADAP BAKTERI Staphylococcus aureus 2021-01-17T18:22:17SE Asia Standard Time Zola Efa Harnis zolaharnis19@gmail.com <p><em>Oral hygiene and dental health are very important, there are various kinds of patogen&nbsp; bacteria in the oral cavity, including the bacteria that cause thrush, Staphylococcus aureus. Gambir is the result of extraction containing polyphenol compounds. The main components contained in gambir consist of alkaloids, flavonoids, tannins and saponins. The use of gambir as a mouthwash preparation is an alternative to replace mouthwash preparations which generally contain an antiseptic in the form of alcohol which can trigger oral cancer. This research is to formulate gambir as a mouthwash and determine the differences in the effectiveness of antibacterial on the growth of Staphylococcus aureus with variations in the concentration of 5%, 10%, 15%. Antibacterial activity test using NA media with agar diffusion method. Physical requirements tests include organoleptic tests, pH tests and viscosity testsshowed that the preparation of 5%, 10% and 15% gambir mouthwash had a pH outside the optimum bacterial growth range of 5. Viscosity of mouthwash preparations of 1.30-5.10 Cp. The antibacterial activity of Staphylococcus aureus in F1 did not produce inhibitory zones, F2 was 5.46 mm, F3 was 9.60 mm and F4 was 10.76 mm while in f5 the positive control was 12.10 mm. Conclusio of this study is gambier mouthwash concentration of 5%, 10% and 15% can inhibit the growth of staphylococcus aureus bacteria.</em></p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/317 EFEKTIVITAS SALEP KOMBINASI EKSTRAK DAUN BANGUN – BANGUN (Coleus amboinicus Lour.) DAN DAUN KELAPA SAWIT (Elaeis guineensis Jacq.) SEBAGAI OBAT LUKA SAYAT 2021-01-17T18:22:14SE Asia Standard Time Rika Puspita Sari rikapuspitasaritambunan@gmail.com <p><em>Bangun-bangun leaves and palm leaves contain various secondary metabolites such as tannins, alkaloids and flavonoids which can healing wound. The aim of this study was to determine the effect of ointment combination of ethanol extract of leaves of bangun- bangun (Coleus amboinicus Lour.) And ethanol extract of palm leaves (Elaeis guineensis Jacq.) In healing wound. The bangun- bangun leaves and the palm leaves are separated from the petiole and then dried in a drying cupboard so that it becomes a simplisia. Simplisia is extracted by maceration method then evaporated with a rotary evaporator and evaporated again on a water bath to produce a thick extract. Thick extracts from the leaves of bangun- bangun and palm leaves are then formulated into ointment preparations with varying concentrations. Each rabbit was shaved on its back then cleaned with 70% alcohol. Furthermore, rabbits were anesthetized using 0.5 ml Lidocain HCL as much as 0.5 ml subcutaneously. Next mark the part that will be injured with a diameter of 2 cm, by lifting the rabbit skin using tweezers and then made a wound using surgical scissors that have been sterilized first with 70% alcohol. Wound diameter measurements showed that all treatment groups from day 1 to day 23 experienced changes in wound diameter. The combination ointment of ethanol extract of leaves wake-up (EEDB) 10% and ethanol extract of palm oil leaves (EEDKS) 10% have a more effective effect in wound healing than single dose.</em></p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/318 EFEK PENYEMBUHAN LUKA BAKAR GEL KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Vernonia Amygdalina) DAN EKSTRAKETANOLDAUNBANGUN–BANGUN(ColeusamboinicusLour) 2021-01-17T18:22:11SE Asia Standard Time Nina Irmayanti Harahap hrpnina19@gmail.com <p><em>african leaves ( Vernonia Amygdalina )and wake-up leaves (Coleus amboinicus Lour)are plants traditional plants that are used as medicine. Leaves african which is contain flavonoid, saponin, tanin and leaves wake up which is contain flavonoid, tanin, saponin and steroid. This study to find aims out as effect healing of burns.<strong>Method </strong>: Sample in this study was african leaves and wake-up leaves which were taken purposively without comparing sampel from other regions, then extrated by maceration using ethanol 96 %. <strong>Result </strong>: Testing of rhe healing effects of burns can be divided in five treatment, positive group using biolacenton , negatif group using basis gel and the last group using the extract ethanol gel EEDA and EEDB concentrations of 4%+2,5%,8%+5%,16%+10%. Given burns to the back of rabbits length with of 2cm, and the gel is applied twice a day for 11 day and diameter measured of the wound. <strong>Conclusion </strong>: The combination of EEDA and EEDA the ethanol extract the concentration of 16% + 10% was the effective control for healing burns. When compared bioplacenton gel as a healing wound in rabbit.</em></p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/320 UJI EFEKTIVITAS GEL KOMBINASI EKSTRAK ETANOL DAUN BANGUN-BANGUN (Coleus amboinicus L.) DAN DAUN KELAPA SAWIT (Elaeis guieensis Jacq) SEBAGAI OBAT LUKA BAKAR TAHUN 2020 2021-01-17T18:22:08SE Asia Standard Time Evi Depiana Gultom evidepiana1@gmail.com <p><em>Coleus amboinicus </em>L<em> leaves and Elaeis guieensis </em>Jacq<em> leaves contain various secondary metabolites such as saponins, tannins, alkaloids and flavonoids that function in wound healing. The purpose of this study was to determine the healing effect of burns using a gel preparation combination of e</em><em>thanolic extract</em><em> of Coleus amboinicus</em><em> L. (</em>EECAL<em>) </em><em>&nbsp;And e</em><em>thanolic extract</em><em> of Elaeis</em> <em>guineensis</em> <em>Jacq.</em><em> (</em>EEEGJ<em>) </em><em>In healing burns. Coleus amboinicus </em>L<em> leaves and Elaeis guieensis </em>Jacq<em> leaves contain are separated from the petiole and then dried in a drying cupboard so that it becomes a simplicia. Simplisia is extracted by maceration method then evaporated with a rotary evaporator and evaporated again on a water bath to produce a thick extract. </em>EECAL<em> and </em>EEEGJ<em> are then formulated into gel preparations with varying concentrations. Each rabbit was shaved on its back then cleaned with 70% alcohol. Furthermore, rabbits were anesthetized using 0.5 ml Lidocain HCL as much as 0.5 ml subcutaneously. Then mark the part that will be injured with a diameter of 2 cm, by lifting the rabbit skin using tweezers and then made a wound using a hot iron plate that has been sterilized beforehand with 70% alcohol.</em> <em>Wound diameter measurements showed that all treatment groups from day 1 to day 20 experienced changes in wound diameter. </em>EECAL<em> 15% and </em>EEEGJ <em>10% have a more effective effect in healing of burn than in their single form.</em>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/321 EFEKTIVITAS KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalinum Del.) DAN EKSTRAK ETANOL DAUN KELAPA SAWIT(Elaeis guineensis Jacq.)TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS PUTIH 2021-01-17T18:22:04SE Asia Standard Time Rani Ardiani raniardiani@yahoo.co.id <p>African leaves <em>(Gymnanthemum amygdalinum Del.)</em> And palm oil leaves <em>(Elaeis guineensis Jacq.)</em> Have been shown to contain flavonoid compounds, where they are efficacious as antidiabetic. This study aims to determine the combined effectivenessof ethanol extract of African leaves and palm oil leaves as antidiabetic in white rats.The study was conducted using the method of alloxan induction and measured using glucometers. 15 animals were divided into 5 groups, namely negative control, positive control, group I combination of ethanol extract of african leaves and oil palm leaves 25 + 25 mg/kg weight, group II combination of ethanol extract of african leaves and palm oil leaves of 50 + 50 mg/kg weight, group III combination of ethanol extract of African leaves and leaves of oil palm 100 + 100 mg/kg weight for 15 days. Examination of antidiabetic effects is done by comparing the KGD value of the rats before and after treatment. The results of this study indicate that the three doses have antidiabetic effects. Data on the differences in the KGD of rats were carried out statistically using the Shapiro Wilk normality test and the Levene homogeneity test and continued with the ANOVA test. The conclusion of this study is that the dose is the most effective in reducing blood glucose levels in rats, which is a dose of 100 + 100 mg/dl because it mostly decreases blood glucose levels.</p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/326 PEMBUATAN SEDIAAN BALSEM STICK DARI SEREH (Cymbopogon citratus (DC.) Stapf) SEBAGAI AROMATERAPI 2021-01-17T18:22:00SE Asia Standard Time okto purba oktopurba@gmail.com <p><strong><em>Introduction:</em></strong><em> Lemongrass plants contain essential oils that can be used as aromatherapy. In the context of efforts to improve public health services in Indonesia, traditional medicine has the opportunity as one of the potential alternative treatments. Society uses traditional medicine in the form of herbal medicine, stew, juice or by rubbing directly on the affected part.</em> <strong><em>Method:</em></strong> <em>Sample in this study was African leaves and palm leaveswhich were taken purposively without comparing samples from other regions,</em><em> To get the essential oil of lemongrass done by distillation. <strong>Result:</strong> Aromatherapy balm from essential oil is formulated with some concentrations of 0%, 15%, 20% and 25% of the evaluation of balm which has been done to 3 qualified balm formulas and has good physical quality. <strong>Concludes:</strong> Citronella essential oil can be made into a supply of balm stick with various concentrations, namely 15%, 20% and 25%. Stick balm made from essential oils of lemongrass can give an aromatherapy effect which is characterized by a refreshing aroma when inhaling the balm preparations and can provide a warm sensation. The best concentration as an aromatherapy stick balm preparation is 25% because it gives the highest aroma and test preferences</em><em>.</em></p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/327 PERBANDINGAN EFEK PENYEMBUHAN LUKA BAKAR ANTARA GEL EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalinum Del.)DENGAN GEL EKSTRAK ETANOL DAUN KELAPA SAWIT ( Elaeis guineensis Jacq.) SERTA KOMBINASINYA PADA KELINCI TAHUN 2019 2021-01-17T18:21:57SE Asia Standard Time Suventi Syafrina Ginting suventi000@gmail.com <p><em>African leaves (Gymnanthemum amygdalinum </em>Del.<em>) And palm leaves (Elaeis guineensis </em>Jacq.<em>) Have secondary metabolites, namely alkaloids, steroids / terpenoids, flavonoids, tannins, and saponins in this study aimed to determine the effectiveness of healing burns. The extract was made by maceration method using 96% ethanol. This test used 3 rabbits, each of which had been burnt into 6 wound areas on the back of the rabbit. First group (positive control), second group (without treatment), third group gel with Arfika leaf ethanol extract concentration of 5%, fourth group gel with palm ethanol extract concentration of 7.5%, fifth group of groups gel with a combination of Arfika leaf ethanol extract concentration of 5% and 7.5% palm oil leaf ethanol extract The burns that have been made are smeared with as much test preparation as possible once a day. The next day the diameter of the wound was measured, then smeared with an adequate amount of gel. This is done until the diameter of the wound is equal to zero or the wound has been covered by new tissue. The results of testing the effectiveness of healing burns showed that all treatment groups had a faster recovery day compared to negative controls. The conclusion of this study is the combination of 5% arfika ethanol extract gel and 7.5% oil palm leaf ethanol extract is the group with the fastest fastest day on the 19th day.</em></p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/330 PERBANDINGAN EFEKTIVITAS EKSTRAK DAN JUS BUAH BIT (Beta vulgaris L.) TERHADAP PENURUNAN KOLESTEROL TIKUS PUTIH 2021-01-17T18:21:53SE Asia Standard Time Linda Margata lindamargata@hotmail.com Dewi Sartika Br Haloho dewisihaloho1904@gmail.com Parhan Parhan parhanidr@gmail.com <p>Kandungan pada buah bit diketahui mampu menurunkan kolesterol dengan cara menghambat pembentukan asam glutarat. Penelitian ini bertujuan untuk membandingkan efek penurunan kolesterol ekstrak dan jus buah bit pada tikus putih. Penelitian ini menggunakan 24 ekor tikus yang dibagi menjadi empat kelompok. Pada penelitian ini tikus diinduksi dengan propiltiourasil (PTU) selama 10 hari lalu masing-masing kelompok diberikan: CMC Na, simvastatin, ekstrak buah bit, dan jus buah bit selama 15 hari. Data penelitian diolah dengan program SPSS menggunakan ANAVA satu-jalur dengan signifikansi 0,05. Kolesterol total sebelum perlakuan pada jus buah bit yaitu 306 mg/dl dan pada ekstrak 311 mg/dl. Kadar kolesterol total setelah perlakuan yaitu 103 mg/dl pada jus dan 148 mg/dl pada ekstrak. Pemberian ekstrak buah bit dan jus buah bit secara signifikan berpengaruh terhadap penurunan kadar kolesterol total. Pemberian ekstrak dan jus buah bit dapat menurunkan kadar kolesterol tikus putih.</p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/331 UJI EFEKTIVITAS ANTIDEPRESAN EKSTRAK BATANG SERAI (Cymbopogon nardus (L.) Rendle) TERHADAP MENCIT PUTIH JANTAN (Mus musculus) 2021-01-17T18:21:49SE Asia Standard Time Delisma Simorangkir Delismasimorangkir@gmail.com <p><em>Depression is a mood disorder that is characterized by profound and sustained sadness and sadness until the loss of life passion. Lemongrass which contains eugenol is thought to have the potential as an antidepressant that works by inhibiting the Mono Amine Oxidase </em>enzyme<em>. This study aims to determine the effectiveness of antidepressant citronella extract (Cymbopogon nardus (L.) Rendle) on male white mice. This study used 5 treatment groups namely CMC Na 0.5%, amitriptilyn, lemongrass extract dose 1.5 mg/kgBB, 15 mg/kgBB and 150 mg/kgBB. Antidepressant testing was determined based on immobility time using the forsed swim test method. Data analysis using statistics was tested for normality and continued with the One Way Anova method with a 95% confidence level. The results showed that the most effective treatment group as an antidepressant was amitriptilyn followed by lemongrass extract dose 150 mg/kgBB. The conclusion of this study is that lemongrass extract dose 150 mg/kgBB has the effectiveness as an antidepressant but is no more effective than the comparison of amitrip</em></p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/332 PENGUJIAN EFEKTIVITAS DIURETIK KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalinum Del.) DAN DAUN KELAPA SAWIT (Elaeis guineensis Jacq.) PADA TIKUS JANTAN 2021-01-17T18:21:46SE Asia Standard Time Delisma Simorangkir Delismasimorangkir@gmail.com <p><em>African Leaf and palm leaf crops have a secondary metabolite content such as alkaloids and flavonoids that are efficacious as diuretics. The purpose of this study is to know the effectiveness of diuretics from the combination&nbsp; African leaf ethanol extract and palm leaf ethanol extract. Methods used Eksperiemental. The test of diuretic activity is conducted divided into 6 treatment groups. Each group consists of 3 tails of white rats. Group 1 (positive control) administered Furosemide 3.6 mg/kgBB, Group 2 (negative control) was given suspension Na-CMC 0.5%, group 3 without treatment as well as groups of 4.5, and 6 in a row administered a combination of African leaf extract doses and extracts Oil palm leaf ethanol in a row of "50 mg/kgBB + 67, 5mg/kgBB"; "100mg/kgBB + 135 mg/kgBB"; and "200 mg/kgBB + 270 mg/kgBB". Each mouse is then given a 20ml NaCl/kgBB as an oral loading dose. Measured urine volume is recorded every hour for 6 hours after it continues to measure urine volume. The results showed that the combination of African leaf ethanol extract dosage and palm leaf ethanol extract had a diuretic effect if it was compared with negative control. The conclusion of the study was the results of the study showed that the combination of African leaf extract dosage and palm leaf extract is the most effective dose of Group 6 (African leaf extract 200 mg/kgBB + palm leaves 270 mg/kgBB ). Because it produces the highest urine volume of 23.01 ml.</em></p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/361 UJI EFEKTIVITAS EKSTRAK ETANOL DARI KULIT PISANG KEPOK (Musa Paradisiaca) UNTUK PENYEMBUHAN LUKA SAYAT PADA TIKUS 2021-01-17T18:21:42SE Asia Standard Time bunga mari sembiring bungamerisembiring@gmail.com <p>Banana peel turns out to have many benefits, one of which is that it can be used to accelerate the wound healing process. Banana peel (Musa Paradisiaca L.) ripe yellow skin is rich in flavonoid compounds, as well as other phenolic compounds, besides containing a lot of carbohydrates, minerals such as potassium and sodium and cellulose. This study aims to determine the wound healing effect of cuts using the Ethanol Extract of Kepok Banana Skins in Rats. Determine the concentration of ethanol extract of Kepok banana peel which is the most effective in healing wound cuts in mice. Knowing a significant difference to the acceleration of wound healing between ethanol extracts of Kepok banana peel and betadin. Research methods conducted included characterization, effectiveness test of ethanol extract of Kepok banana peel, manufacture of extract by maceration using ethanol 96% solvent, test of effectiveness of ethanol extract of kepok banana peel on cut wounds in mice. Data analysis using SPSS is Anova One Way Test. From the results of this study the ethanol extract of Kepok banana peel can have an effect on wound healing in mice. Ethanol extract of Kepok banana peel is faster than betadin in healing wound cuts in mice. Ethanol extract of Kepok banana peel with a dose of 750 Mg / kg BW is the most effective in healing wound cuts in rats.</p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/362 the PENGARUH PEMBERIAN SIMETIDIN TERHADAP PROFIL FARMAKOKINETIKA PARASETAMOL DENGAN METODE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) TAHUN 2020 2021-01-17T18:21:39SE Asia Standard Time Christica Ilsana Surbakti christicailsannas@gmail.com <p><em>Paracetamol is a safe analgesic and antipyretic drug with low side effects, effective and well tolerated. In some cases there is a drug interaction between paracetamol and other drugs. The purpose of this study is to determine the effect of cimetidine administration on paracetamol pharmacokinetic profiles. The method used in this study was an experimental method using 3 rabbits. Rabbits are divided into 3 groups. The first treatment group was given paracetamol suspension, the second treatment group was giving cimetidine 1 hour before paracetamol and the third group was giving cimetidine and paracetamol simultaneously. The dose of the drug has been adjusted to each rabbit. Measurement of plasma paracetamol drug levels was carried out using a High Performance Liquid Chromatography (HPLC) tool. The results of the study showed that the pharmacokinetic parameter values </em><em>​​</em><em>did not show any significant effect on each group. Cimetidine administration simultaneously affects paracetamol pharmacokinetic parameters but not significantly. Likewise with the administration with a time span of 1 hour, did not show any significant changes in the pharmacokinetics of paracetamol.</em></p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/368 AKTIVITAS ANTIBAKTERI EKSTRAK KULIT BUAH PEPAYA CALIFORNIA (Carica papaya L) TERHADAP BAKTERI Escherchia coli 2021-01-17T18:21:32SE Asia Standard Time Romaulianna Theresia Marbun romamarbun@yahoo.com Novidawati Br Situmorang romamarbun7@gmail.com <p>Infectious diseases caused by bacteria, require antibiotics for treatment. Incorrect use of antibiotics causes. the occurrence of resistance. From the research, it was found that many medicinal plants can be used to cure infectious diseases. One of them is California Papaya Fruit Skin (<em>Carica papaya L</em>). The purpose of this study was to determine the active substance in the skin of the Carica Papaya Fruit as an antibacterial agent and to determine the activity of KBPC extract against E. coli bacteria. This research method is a laboratory experiment where the sample in this study is 3 kg. Phytochemical test results with positive ethanol extraction containing flavonoids, saponins, steroids. Where favonoids can be potential as antibacterial through 3 mechanisms, namely by inhibiting nucleic acid synthesis, inhibiting cell membrane function and inhibiting energy metabolism. The results of the antibacterial activity test against E. coli bacteria were carried out with several concentrations, namely 20%, 40%, 60%, 80%, 100%, the test results obtained from the concentration of 20% of 8.76 mm the highest inhibitory power at the concentration 100% of 19.33 mm. Conclusion KBPC extract has antibacterial activity against E. Coli bacteria.</p> 2020-11-02T06:44:03SE Asia Standard Time ##submission.copyrightStatement## http://ejournal.delihusada.ac.id/index.php/JPFH/article/view/387 ANTIBACTERIAL ACTIVITY TEST OF LIME JUICE EXTRACT AGAINST ESCHERICHIA COLI 2021-01-17T18:21:35SE Asia Standard Time Nerdy Nerdy nerdy190690@gmail.com Palas Tarigan palas@delihusada.ac.id Elysa Elysa elysa@delihusada.ac.id Puji Lestari pujilestari@delihusada.ac.id Siti Nurmalisa sitinurmalisa@delihusada.ac.id <p>Lime (<em>Citrus aurantifolia</em> Swingle) is known to have seceral phytochemical contents (flavonoids and saponins) that can be memiliki berbagai aktivitas farmakologis yang bermanfaat. Salah satu aktivitas farmaokologis yang diberikan oleh flavonoid adalah sebagai antibacterial activity. The aims of this research was to determine the antibacterial activity of lime juice against <em>Escherichia coli</em> bacteria. This research used an experimental laboratory research method using antibacterial effectiveness trials against the growth of <em>Escherichia coli </em>bacteria. The research design for antibacterial effectiveness used the lime fruit extract method with 4 treatment groups, positive control and negative control. Antibacterial effectiveness was observed the inhibition zone diameter by disc diffusion method. Results of the <em>Escherichia coli</em> antibacterial effectiveness test obtained at a concentration of 100% had antibacterial activity with an average diameter of the inhibition zone 19.9 mm. The lowest concentration that still provides antibacterial resistance against <em>Escherichia coli</em> is at a concentration of 12.5% ​​with an average diameter of the inhibition zone of 17.9 mm. The results obtained indicated that the antibacterial effectiveness test on lime fruit extract is very strong. At a concentration of 100% it has the best antibacterial activity, the inhibition zone diameter similar with the inhibition zone of 500 mg tetracycline.</p> 2020-10-31T00:00:00SE Asia Standard Time ##submission.copyrightStatement##