Jurnal Penelitian Farmasi & Herbal 2022-04-28T13:04:56SE Asia Daylight Time Dewi Safitri Ginting Open Journal Systems <div style="text-align: justify;"> <p>Jurnal Penelitian Farmasi &amp; Herbal memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat, serta artikel ilmiah di bidang farmasi dan herbal. Artikel penelitian dan pengabdian masyarakat yang dimuat dlam jurnal ini merupakan topik penting dalam pengembangan ilmu pengetahuan di bidang farmasi dan herbal, membantu pemecahan masalah seputar kefarmasian dan membantu meningkatkan kualitas hidup manusia. Jurnal Penelitian Farmasi &amp; Herbal &nbsp;bersifat independen, ilmiah, memberi kesempatan yang sama kepada akademisi dari berbagai jenjang dan asal pendidikan tinggi.</p> </div> Uji Efektivitas Antidiabetes Kombinasi Ekstrak Buah Pare (Momordica charantia L.) Dan Kelopak Bunga Rosella (Hibiscus sabdariffa L.) Pada Tikus Jantan Putih Sebagai Hewan Percobaan 2022-04-28T13:02:34SE Asia Daylight Time Anggun Syafitri <p><em>Diabetes mellitus is a chronic metabolic disease characterized by an increase in blood glucose levels which can be treated with traditional treatments derived from plants. One of the example is a plant that can reduce blood glucose levels are bitter melon and rosella which contain flavonoids to reduce blood glucose by increasing cell sensitivity to insulin and stimulating insulin release in pancreatic β cells. The objective of the research is to determine the effect of the combination of bitter melon extract and rosella petal extract in reducing blood glucose levels compared to glibenclamide. The method of the research is an experimental study used 21 rats induced by alloxan and divided into 7 groups. Extraction using maceration method with 80% ethanol. From the results of the study, each treatment group experienced a decrease in blood glucose levels. From the 7 treatment groups, the best reduction in blood glucose levels were the third combination group. Among the three combination groups, the combination dose of 225 mg/kgBB of bitter melon and 195 mg/kgBB of rosella flower petals was the best compared to glibenclamide in reducing blood glucose levels. The conclusion of the research is combination of bitter melon extract and rosella flower petals have an effect that are more effective in reducing blood glucose levels compared to glibenclamide and their single extract.</em></p> 2022-04-28T12:53:24SE Asia Daylight Time ##submission.copyrightStatement## ANALISIS SALAH SATU OBAT HERBAL DI SUMATERA UTARA TAHUN 2021 2022-04-28T13:02:40SE Asia Daylight Time Christivo Tambusai Nerdy Nerdy Firdaus Fahdi <p>The existence of competition between chemical and traditional drugs has resulted in increasingly being displaced from the market. In addition, another problem that traditional medicine has not been widely used for both self-medication and formal health services is that most of the efficacy of traditional medicine has not been scientifically tested. Therefore, it is very important to do an analysis through research. The purpose of this study was to determine the efficacy of traditional medicine PT. Amanah Berkah Kencana in improving health and body immunity. The research method used in this study is a descriptive method with a cross- sectional &nbsp;approach. &nbsp;The &nbsp;main &nbsp;informants &nbsp;in &nbsp;this &nbsp;study &nbsp;were &nbsp;consumers &nbsp;of traditional medicine PT. Amanah Berkah Kencana. This research was conducted in North Sumatra from December 2021 to February 2022.</p> <p>The results of the study explain that 82.5% strongly agree. The results of this percentage show a very good picture for consumers who use Haseda traditional medicine in maintaining health and increasing human immunity. The remaining</p> <p>17.5% do not agree because of lack of public education and knowledge about the use and benefits of traditional medicine for health.</p> <p>For health observers, there should be socialization to the public about the use of traditional medicines.</p> 2022-04-28T12:54:47SE Asia Daylight Time ##submission.copyrightStatement## FORMULASI DAN UJI EKTIVITAS ANTIBAKTERI SEDIAAN LOTION EKSTRAK ETANOL DAUN SAWAO TERHADAP BAKTERI Stapylococcuc aureus dan Escherchia coli 2022-04-28T13:02:48SE Asia Daylight Time Pintata Sembiring <p>Manila sapodilla leaves contain phytochemical mixtures of alkaloids, flavonoids, saponins, tannins, terpenoids and glycosides which are known to have antibacterial movement of Staphylococcus aureus and Escherichia coli. The reason for this study was whether the planning of sapodilla leaf extricate salve can be utilized as an enemy of bacterial technique. This exploration was led utilizing a trial which plans to decide all side effects or impacts that emerge, because of specific medicines. Sawo Leaf Ethanol Extract was completed by submerging maceration utilizing 96% ethanol. Antibacterial action testing was done on Sawo leaf extricate with different centralizations of 5%, 10% and 20% and Chaladine cream as a positive control was completed utilizing the discdiffusion strategy. The consequences of the restraint zone movement of Staphylococcus aureus antibacterial lotio arrangements Chaladine sapodilla leaf remove 18 mm, Extract focus 5% 14.5 mm, Extract fixation 10% 20.3 mm, Extract focus 20% 15.46 mm, The aftereffects of the inhibitory zone action in the cream readiness antibacterial concentrate of sapodilla lotio leaf Escherichia coli lotio Chaladine 14 mm, Extract focus 5% 14.16 mm, Extract fixation 10% 20.3 mm, Extract fixation 20% 16.06 mm &gt; 0.05, this demonstrates that the information are typically dispersed, homogeneity trial of 2 gatherings of microscopic organisms and shows a meaning of p &gt; 0.05, showing that the information utilized came from homogeneous information. This demonstrates that Lotio ethanol concentrate of sapodilla leaves has antibacterial movement.</p> 2022-04-28T12:55:20SE Asia Daylight Time ##submission.copyrightStatement## UJI EFEKTIVITAS SALEP EKSTRAK ETANOL DAUN BUNGA KERTAS (BOUGAINVILLEA GLABRA) TERHADAP LUKA EKSISI PADA TIKUS JANTAN PEMBANDING POVIDONE IODINE SALEP 2022-04-28T13:03:00SE Asia Daylight Time Delisma Simorangkir <p><em>The wound is a physical injury that results in tears and damage to skin tissue. One type of wound is excision wound, excision wound is of the a wound that is caused by cutting tissue by sharp object scratches</em><strong><em>.</em></strong><em> The main goal in wound management is to achieve rapid healing with optimal function and good results. That can be achieved by preventing further infection and trauma with the availability of an environment that can optimize the healing of the wound. One plant that has the potential to heal wounds is the paper petal plant. The purpose of thes study is to find out the effectiveness of giving paper petal extract to the healing of excision wounds in male rats. The study conducted in the Laboratory Health Institute of the Deli Husada Deli Tua. The extracts formulated into ointment preparations with concentrations of 10%, 15%, and 20% then conducted evaluation of ointment preparations, namely organoleptic tests, homogeneity tests, ph tests, visicosity tests, hedonic tests and spread power tests. The results of organoleptic tests and irritant tests of paper petal ethanol extract ointment preparations, all concentrations were declared good while in the most preferred hedonic test was a concentration of 10%. From the results of the spread test is a concentration of 15% with a static test value on the 21st day which is 6.3000 where this value is equal to the value of povidone iodine, while in the pH test on the 21st day the concentration that sees the best statistic test value is 10% concentration with a value of 6.4467 which is close to the value of povidone iodine which is 7.3133. The results of the study is each treatment group experienced a decrease in the diameter of the cut wound. Of the 5 treatment groups, the best reduction in the diameter of the cut wound was the positive control group (povidone iodine) and the 20% concentration where the statistic test value on the 15th day was 0.0000 where this value was equal to the value of povidone iodine.</em></p> <p><em>&nbsp;</em></p> 2022-04-28T12:55:50SE Asia Daylight Time ##submission.copyrightStatement## FORMULASI DAN UJI AKTIVITAS ANTI BAKTERI SEDIAAN SALEP EKSTRAK ETANOL DAUN SIRIH CINA (peperomia pellucida) TERHADAP BAKTERI Staphylococcus Aureus 2022-04-28T13:03:08SE Asia Daylight Time Rika Puspita Sari <p><em>Chinese betel leaf (Peperomiapellucida) is </em><em>one among </em><em>the wild herbaceous plants belonging to the Piperaceae family which </em><em>is employed </em><em>as a natural medicine. </em><em>The study's goal was to determine the antibacterial activity of an ethanol extract of Chinese betel leaf ointment against Staphylococcus aureus, as well as the optimal concentration.</em><em>&nbsp;The test of the study was </em><em>administered </em><em>by the diffusion method using disc paper. The results of the characterization examination of Chinese betel leaf simplicia powder obtained water soluble extract content of 64.58%, ethanol soluble extract content of 24.95%, total ash content </em><em>of three </em><em>3</em><em>.2%, 5.9 % water of content and 0.28% acid insoluble ash content of and Simplisia contains alkaloids, flavonoids, tannins, and saponins. Staphylococcus aureus obtained </em><em>a degree </em><em>of 8% with a diameter of 16.81, the diameter of the inhibition zone of the Chinese betel leaf ethanol extract against. The ethanol extract of Chinese betel leaf exhibits antibacterial action against Staphylococcus aureus, according to the findings of the study.</em></p> <p><strong><em>Keywords: Antibacterial activity, Chinese betel leaf Staphylococcus aureus</em></strong></p> 2022-04-28T12:56:22SE Asia Daylight Time ##submission.copyrightStatement## The FORMULATION AND EVALUATION O FORMULATION AND EVALUATION OF THE PREPARATION OF HAIR TONIC Ethanol Extract of Patchouli Leaves (Pogostemon cablin Benth.) TO OVERCOME HAIR LOSS 2022-04-28T13:03:13SE Asia Daylight Time Bunga Rimta Barus Linta Meliala <p><em>Nilam leaves contain flavonoids. flavonoids that have activity that can accelerate hair growth and prevent hair loss. The purpose of the study was to make a hair tonic preparation containing patchouli leaf extract and to determine the concentration of the best formula to treat hair loss. Hair tonic is made with nilam&nbsp; leaf extract at concentrations of 5%, 10%, 15%. The ingredients for making Hair Tonic include propylene glycol, propyl paraben, methyl paraben, menthol, sodium metabisulfite, 96% ethanol, Ol. Rosae, Aquades. The method of the study an experimental method with extraction by maceration for 5 days and remaceration for 2 days using 96% ethanol as solvent. Evaluation of Hair Tonic preparations includes homogeneity, pH, organoleptic, viscosity, irritation, preference, and hair growth effectiveness test. The effectiveness test on hair growth in rabbits was carried out on 5 rabbits with 5 treatment groups, namely, positive control group Hair Tonic nature, negative control group, 5% concentration group, 10% concentration group, and 15% concentration group. The analysis of the data on growth testing using One Way Anova. Hair growth data on day 12 were positive control 0.95 mm, negative control 0.03 mm, formula 1 (5%) 0.08 mm, formula 2 (10%) 0.13 mm, formula 3 (15%) 0.83mm. The best formula to treat hair loss is hair tonic with a concentration of 15% nilam leaf ethanol extract. It can be concluded that the greater the concentration of nilam leaf extract given to each treatment, the faster the hair growth.</em></p> 2022-04-28T12:56:53SE Asia Daylight Time ##submission.copyrightStatement## FORMULASI SEDIAAN BLUSH ON DARI EKSTRAK KUBIS UNGU (Brassica Oleracea L. var. capitates f. rubra) SEBAGAI PEWARNA DALAM BENTUK COMPACT POWDER 2022-04-28T13:03:25SE Asia Daylight Time Nadia Nadia <p><em>Cosmetics have been known to humans since centuries ago. Since the last 40 years, cosmetics has grown rapidly. Quantias and the quality of biological materials for use on the skin are increasing. Blush on is created from attractive colors and of course using coloring agents. Purple cabbage extract is used as a dye in blush on with a concentration of 30% and Isopropyl myristate as a binder with various concentrations of 0.5%, 1.0% and 2.0%. Purple cabbage extract was obtained by 96% ethanol maceration, then filtered and rotary using a rotary evaporator, then evaporated in a water bath with a temperature of 700 C. Blush on is made by pressing. The extract yield obtained was 18.68%. The observations show that preparations with a concentration of Isopropyl myristate 1.0% are better and more preferable because the preparation is not brittle and not too hard. In the pH test, all dosages meet the requirements. In the irritation test, all preparations did not cause irritation reactions to all panelists.</em> <em>Purple cabbage extract can be used as a natural dye in the process of making blush on and the best concentration of Isopropyl myristate is 1.0%.</em></p> 2022-04-28T12:57:24SE Asia Daylight Time ##submission.copyrightStatement## FORMULASI SEDIAAN MASKER Gel Peel Off EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium Guajava L.) SEBAGAI PEMBERSIH WAJAH 2022-04-28T13:03:33SE Asia Daylight Time Palas Tarigan <p><em>Guava plants contain psiditanin “eugenol” essential oil, tannis, flavonoids, saponins, alkaloids. Compounds that have very good strength come from the class of flavanoids, vitamin C which can be usedas a facial cleanser. This study aims to determine the preparation of peel gel mask of guava leaf extract is effective as a facial cleanser and to find out the peel off gel mask of guava leaf extract can irritate the skin of volunteers. The made with 4 formulation with concentrations of 0%, 10%, 15%, 20%. The testing of the peel off gel mask formulation ethanol extract on cleanliness was carried out with the analysis of the ms. Excel bar diagram. The results showed that (psidium guajava L) contain flavonoid, alkaloids, tannins and saponins. The results of the characteristics of the simplicia powder were 5,42% water content 9,56% total ash content 0,34% acid insoluble ash, ethanol soluble extract 64,295. The results of the peel off gel mask formulation test with a cleanliness test on the panelists facial skin concentration of 15% included in the category can clean the panelist’s facial skin.Guava leaf ethanol extract has a facial cleansing activitywith a score of 3</em></p> <p><em>&nbsp;</em></p> 2022-04-28T12:58:08SE Asia Daylight Time ##submission.copyrightStatement## UJI AKTIVITAS EKSTRAK BUAH ARA (Ficus carica Linn) TERHADAP TIKUS YANG DI INDUKSI ALOKSAN 2022-04-28T13:03:38SE Asia Daylight Time Atika Patni Suri <p><em>Diabetes is a disease in </em><em>which the blood sugar level rises above the normal level. When blood sugar levels are regulated by the hormone insulin produced by the pancreas. The fig fruit (Ficus carica Linn) is a plant that is thought to be used as an herbal remedy in the management of diabetes.</em> <em>Contains flavonoids which are thought to have potential as antidiabetic. Flavonoid mechanism in reducing blood glucose levels is to reduce glucose absorption and increase insulin secretion. Flavonoids are phenol compounds that have several pharmacological activities. </em>Objective <em>knowing antidiabetic activity of fig extract (Ficus carica Linn) against mice induced by alloxan</em><em>.</em> <em>The </em><em>process used is a 70% ethanol solvent immersion process. This study method is designed before and after the control group. Fifteen rats were divided into 5 treatment groups. 1 (negative control) received the CMC Na 1% group, 2 (positive control) received glibenclamide 0.09 mg / kgBB, 3, 4 and 5 received 9 mg / kgBB, 18 mg / kgBB, and 36 mg / kg. The fig extract was administered at a dose of kgBB. Previously, rats were given alloxan 125 mg / kg BB intraperitoneally for 3 days and mice with a blood glucose level of ± 200 mg / dL were used in this study.</em> <em>The results of this study showed that glibenclamide 0,09 mg/kgBB and fig extract dose 36 mg/kgBB could reduce the best glucose levels for seven days</em>. Conclusion <em>the best glibenclamid as antidiabetic in male white rats induced by alloxan and fig extract at a dose of 36 mg/kgBB 1,5% concentration is good as antidiabetic mellitus in male white mice induced by alloxan. </em></p> 2022-04-28T12:58:34SE Asia Daylight Time ##submission.copyrightStatement## PEMBUATAN MIKROKRISTALIN SELULOSA (MCC) dari BATANG PISANG MAS (Musa acuminata colla) dengan AVICEL PH 102 SEBAGAI PEMBANDING TAHUN 2019 2022-04-28T13:03:49SE Asia Daylight Time Erdiwan Erdiwan <p><em>Commercial cellulose microcrystalline known as Avicel PH 102, which is a tablet filling material Avicel PH 102 which is expensive and uses a lot of it, it is necessary to look for other alternative sources of producing microcrystalline cellulose. The Waste of banana stem contains water content of 80-90%, cellulose 63-64%, hemicellulose 20%, and lignin 5% and contains 11-12% other constituens so that it can be the basic material for making MCC. This study aimed to isolate α-cellulose from banana mas stems and characterize microcrystalline cellulose with Avicel PH 102. The method of this study was an experimental. Microcrystalline banana stem cellulose is obtained by heating banana stem powder with 4% NaOH which serves to dissolve lignin, then bleached with 2.5% NaOCl, 17.5%&nbsp; NaOH heated to dissolve β-cellulose and γ-cellulose, and heated with HCL 2 N . </em><em>The results </em><em>are hydrolyzed with </em><em>α</em><em>-cellulose and then hydrolyzed with 2.5N HCl to give microcrystalline cellulose, which is characterized and compared to Avicel PH102.</em><em> The result of characterization of banana mas stem microcrystalline cellulose and Avicel PH 102 which were obtained respectively is organoleptic tests of coarse powder, white, doesn’t have any smells; pH 6.6 and 6.5; solubility of substances in water 0.023 and 0.023%; total ash content are 0.17 and 0.12%; decrease of drying 5.47 and 5.28%; real density 0.337 and 0.404 g / cm3; true type weight 1.43 and 1.43 g / cm3; incompressible density 0.478 and 0.480 g / cm3; compressibility index 41.77 and 18.85%; Hausner index 1.41 and 1.18; porosity; 76.43 and 93.640%. Based on the results of the study concluded that microcrystalline cellulose can be made from banana mas stems and has the same characteristics as Avicel PH 102.</em></p> 2022-04-28T12:59:28SE Asia Daylight Time ##submission.copyrightStatement## Pengaruh Pemberian Omeprazole Terhadap Profil Farmakokinetika Piroxicam Dengan Metode Kromatografi Cair Kinerja Tinggi (KCKT) 2022-04-28T13:04:00SE Asia Daylight Time Dasma Arihan Nauli Sipayung <p><em>Piroxicam is an </em><em>anti-inflammatory drug belonging to the NSAID group and is also used as an analgesic and anti-rheumatic drug. Its use is often combined with stomach medicines, as the side effects of piroxicam can irritate the stomach. One of them is omeprazole. Since piroxicam and omeprazole act on the same enzyme, CYP450, they can affect the pharmacokinetic profile, especially at the metabolic stage and excretion of piroxicam</em><em>. The purpose of this study was to determine the effect of omeprazole on the pharmacokinetic profile of piroxicam especially in the metabolic phase and excretion. </em><em>The method used in this study was </em><em>an experimental method using three male rabbits. These rabbits are divided into three groups.</em> <em>The first treatment group was giving pyroxicam solution 0.653 mg / kg body weight, the second treatment group gave piroxicam 0.653 mg / kg body weight that one hour before was given omeprazole 1.2 mg / kg body weight and the third group treated with piroxicam 0.7 mg / kg body weight at the same time with omeprazole 1,4 mg / kg body weight. </em><em>Plasma levels of the drug piroxicam are measured using a high performance liquid chromatography (HPLC) tool. The verification method is executed. This is the determination of LOD and LOQ values, accuracy and accuracy testing. The result of data analysis using t-table. The results showed that there was an increase or difference in pharmacokinetic parameter values </em><em>​​</em><em>during the absorption phase, but no significant effect was shown for each group. Pharmacokinetic parameter values </em><em>​​</em><em>for metabolic stages and excretion were reduced and no significant difference was shown between the groups. Simultaneous administration of omeprazole and piroxicam and administration of piroxicam 1 hour before omeprazole may inhibit piroxicam-metabolizing enzymes and thus affect pharmacokinetic parameters and excretion during absorption, but are not significant.</em></p> <p><strong><em>&nbsp;</em></strong></p> 2022-04-28T12:59:49SE Asia Daylight Time ##submission.copyrightStatement## PENGUJIAN EFEKTIVITAS PENYEMBUHAN LUKA BAKAR GEL EKSTRAK ETANOL DAUN TEMBAKAU (Nicotiana tabacum L.) PADA TIKUS 2022-04-28T13:04:11SE Asia Daylight Time Mona Hutagalung <p><em>Tobacco leaves (Nicotiana tabacum L.) have secondary metabolites namely alkaloids as antibacterial, flavonoids and steroids / terpenoids as antimicrobials and adstringers which play a role in wound shrinkage, efficacious saponins stimulate collagen formation</em><em>. </em><em>This study aims to determine the effectiveness of tobacco leaf gel </em><em>ethanol extract in the healing of burns. Tobacco leaf extract was prepared using a 96% ethanol immersion process. This study of tobacco leaf extract is prescribed in the form of gels at 5%, 10%, and 15% concentrations. There were five groups in this study. The first group (positive control), the second group (negative control), and the third group are tobacco leaf ethanol extract gels 5%, 10%, and 15%. In this study, 15 rats with burns on the backs of mice coated with the test preparation will be measured and photographed once daily. This is done until the wound is 0 cm in diameter or covered with new tissue. The data results of the mean wound healing rate data were statistically tested using the SPSS program. We analyzed the data using Oneway, ANOVA, TukeysB, and LSD to see the actual differences between the processes. The data results of the analysis on day 16 showed that the 15% tobacco leaf ethanol extract had a wound healing effect that was not significantly different from the positive control</em> <em>(Bioplasenton) (p&gt; 0.05). cure burns that are comparable to comparable drugs (Bioplasenton). The conclusion of this study is that the most effective gel concentration is 15% with the day of recovery on the 16th day.</em></p> 2022-04-28T13:00:17SE Asia Daylight Time ##submission.copyrightStatement## Formulasi Dan Evaluasi Sediaan Krim Pewarna Rambut Dari Ekstrak Etanol Umbi Bit (Beta vulgaris L.) 2022-04-28T13:04:21SE Asia Daylight Time Sarah Damayanti <p><em>The use of natural hair dyes is a solution to the problem of synthetic hair dyes. one of the plants such as beetroot contains a lot of secondary metabolites, one of which is flavonoids which&nbsp; can provide specific dyes. The natural color found in beetroot can be used as a natural dye in cosmetics. To find out at what concentration the beetroot produces the most optimal quality physical color of the hair dye preparation. This research method was carried out including making beetroot (Beta vulgaris L.) ethanol extract by maceration for 5 days with 95% ethanol solvent and continued remeseration with the same solvent. The extract formula used was 10%, 15%, and 20% physical evaluation carried out included organoleptic test, irritation test, pH test, homogeneity test, stability test for washing, stability test for sunlight. As a result of inspection of the three hair dye cream formulations, the formulations met the requirements of the test formulations. The results of the hair tack test showed that it gave a good color at a density of 20% time. In the color stability test of the wash after 15 shampoo washes, all three formulations have a fixed color up to 9 washes. Also, in terms of color stability to sunlight, after exposure to direct sunlight, the color appears to change slightly, making the hair darker than before. The result of the concentration of beetroot ethanol extract that gives the best color is a concentration of 20%.</em></p> 2022-04-28T13:00:53SE Asia Daylight Time ##submission.copyrightStatement## FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN LOTION EKSTRAK ETANOL DAUN DUKU (Lansium domesticum Corr.) TERHADAP BAKTERI Staphylococcus Aureus PADA PENYEMBUHAN PENYAKIT KULIT BERNANAH TAHUN 2022 2022-04-28T13:04:29SE Asia Daylight Time sulasmi sulasmi <p><em>Duku leaves (Lansium domesticum Corr.) can be used as an alternative treatment for skin-related diseases such as boils caused by Stapylococcus aureus. Duku leaves contain flavonoids, saponins and triterpenoids that are able to provide antibacterial effects. This study aims to formulate duku leaf extract intopreparations lotion antibacterialagainst Stapylococcus aureus. The study was conducted experimentally, the sample was extracted by maceration method, then the extract was formulated intopreparations lotion with concentrations of 4%, 8% and 12%, of the three concentrations compared with positive control (caladin), negative control (basis lotion), then evaluation was carried out in the form organoleptic test, homogeneity test, dispersion test, pH test, irritation test and hedonic test for each formulation. After the evaluation data was obtained, an antibacterial test was carried out for each formulation. Then proceed with statistical analysis &nbsp;method One Way Anova. The results obtained at a concentration of 4% have the best formula in terms of organoleptic and hedonic (attractive color), thick shape, smells of perfume). In terms of pH it has a pH of 7.0; spreadability (6.27 cm ± 0.4); There is no irritation in this formulation. Based on statistical analysis, the sig Anova value of P &lt; 0.05 (0.000) showed that there was a difference between each formulation in the concentration variation when compared to the positive control. Based on the antibacterial test the formulation concentration of 12% had the best antibacterial properties, namely 16.82 mm ± 4.00 compared to other formulations and the positive control had the best antibacterial properties, namely 17.32 mm ± 1.58. Based on statistical analysis, sig P value &lt; 0.05 (0.000) which means that there are differences in each antibacterial formulation when compared with positive controls. The results showed that in terms of formulation, lotion with a concentration of 4% was the best formulation compared to other formulas. Based on antibacterial lotion concentration of 12% has the best antibacterial properties compared to other formulas.</em></p> 2022-04-28T13:01:18SE Asia Daylight Time ##submission.copyrightStatement## BUAH MENGKUDU (Morinda citrifolia), KANDUNGAN DAN EFEKTIVITASNYA SEBAGAI ANTIHIPERTENSI: LITERATURE REVIEW 2022-04-28T13:04:36SE Asia Daylight Time Wahyudi Wahyudi <p><strong><em>Background:</em></strong> <em>Hypertension is one of a disease high prevalence in the world today, often called the silent killer because it generally does not cause symptoms in sufferers. This disease is characterized by increased contraction of blood vessels which increases blood pressure against the walls of blood vessels. Mengkudu (Morinda citrifolia) is one of the most widely grown plants in Indonesia which has effective antihypertensive properties. Previous studies have shown that mengkudu can lower blood pressure significantly compared to negative controls. The purpose of writing this article is to make a literature review that comprehensively discusses the effectiveness of mengkudu as an antihypertensive from previous studies that have been carried out.</em></p> <p><strong><em>Methods: </em></strong><em>The writing of this article uses the literature review method on research articles found in the Google Scholar and Science Direct database using the keywords mengkudu, Morinda Citrifolia, hypertension and blood pressure. The criteria for the selected articles are articles published between 2000-2022 in both national and international journals. Literature review was conducted by comparing research methods, processing methods and the results obtained from each article.</em></p> <p><strong><em>Results: </em></strong><em>The results of previous studies showed that&nbsp; mengkudu had a significant effect on reducing blood pressure. The decrease in blood pressure is related to the content of prexeronin (endothelial vasoactive), scopoletin (causing vasodilation) and xeronine (diuretic effect) contained in mengkudu which can lower blood pressure by different mechanisms.</em></p> <p><strong><em>Conlusion:</em></strong><em> The content of mengkudu has the potential as an antihypertensive because it can significantly lower blood pressure.</em></p> 2022-04-28T13:01:45SE Asia Daylight Time ##submission.copyrightStatement##