UJI EFEKTIVITAS SALEP EKSTRAK ETANOL DAUN BUNGA KERTAS (BOUGAINVILLEA GLABRA) TERHADAP LUKA EKSISI PADA TIKUS JANTAN PEMBANDING POVIDONE IODINE SALEP

UJI EFEKTIVITAS SALEP EKSTRAK ETANOL DAUN BUNGA KERTAS (BOUGAINVILLEA GLABRA) TERHADAP LUKA EKSISI PADA TIKUS JANTAN PEMBANDING POVIDONE IODINE SALEP

  • Delisma Simorangkir Institut Kesehatan Deli Husada
Keywords: Bougainvillea glabra, Paper petal, Wound ointment, Excision wound.

Abstract

The wound is a physical injury that results in tears and damage to skin tissue. One type of wound is excision wound, excision wound is of the a wound that is caused by cutting tissue by sharp object scratches. The main goal in wound management is to achieve rapid healing with optimal function and good results. That can be achieved by preventing further infection and trauma with the availability of an environment that can optimize the healing of the wound. One plant that has the potential to heal wounds is the paper petal plant. The purpose of thes study is to find out the effectiveness of giving paper petal extract to the healing of excision wounds in male rats. The study conducted in the Laboratory Health Institute of the Deli Husada Deli Tua. The extracts formulated into ointment preparations with concentrations of 10%, 15%, and 20% then conducted evaluation of ointment preparations, namely organoleptic tests, homogeneity tests, ph tests, visicosity tests, hedonic tests and spread power tests. The results of organoleptic tests and irritant tests of paper petal ethanol extract ointment preparations, all concentrations were declared good while in the most preferred hedonic test was a concentration of 10%. From the results of the spread test is a concentration of 15% with a static test value on the 21st day which is 6.3000 where this value is equal to the value of povidone iodine, while in the pH test on the 21st day the concentration that sees the best statistic test value is 10% concentration with a value of 6.4467 which is close to the value of povidone iodine which is 7.3133. The results of the study is each treatment group experienced a decrease in the diameter of the cut wound. Of the 5 treatment groups, the best reduction in the diameter of the cut wound was the positive control group (povidone iodine) and the 20% concentration where the statistic test value on the 15th day was 0.0000 where this value was equal to the value of povidone iodine.

 

Downloads

Download data is not yet available.

References

DAFTAR PUSTAKA
Anief, M. (2008). Ilmu Meracik Obat. Yogyakarta: Gadjah Mada University Press. Hal 52-62.
Budiyono S. 2011. Anatomi Tubuh Manusia. Laskar Aksara. Hal: 37-40
Dira, Yanuarista, Ria Afriyanti. 2018. Uji Aktifitas Ekstrak Pricarp Kulit Buah Manggis Terpurifikasi Dalam Penyembuhan Luka Eksisi. Talenta Conference Serles. Padang . 135-137
Ditjen POM. (2016). Farmakope Indonesia. Edisi III. Jakarta: Departemen Kesehatan RI. Hal XXX.
Ditjen POM. 1995. Farmakope indonesia. Ed IV. Jakarta. Departemen Kesehatan Republik Indonesia. Hal: 18.
Efi A. 2003. Sifat Dan Manfaat Temulawak. Agromedia. Hal: 10-15
Fadhil MT, Cyntia R, Faisol R. 2019. Formulasi dan evaluasi karakteristik salep herbal dengan ekstrak binahong (andradera cordifolia) dan ikan gabus (channa striata). Seminastika. Balikpapan. 9-11
Fisca, F.S., Dinda, S., Furqan, N.I., Halimatussakdiah, Puji, W., Ulil, A,. 2018. Skrining Fitokimia Ekstrak Daun Temurui (Murraya koegini (L.) Spreng). Jurnal Jeumpa. 5(1)- Juli 2018.
Hadi S., Saputra. 2020. Mikroemulsi Ekstrak Bawang Tiwai Sebgai Pembawa Zat Warna, Antioksidan Dan Antimikroba Pangan. CV Budi Utama. 7-9
Harborne, J.B. (1984). Metode Fitokimia. Terbitan Kedua. Bandung: ITB. Hal 69,
147-149, 234-264
Haryadi DI dan Rahman AW. 2018. Optimasi Formula Gel Serbuk Getah Ashitaba (Angelica Keiskei Koidzumi) dan Uji Aktivitas Terhadap Lama Penyembuhan Luka Eksisi Pada Kelinci. Pharmauho. 4 (5)

Kaisoon, I. Konczak, S. Siriamornpun. 2012. Potential Health Enhancing
Properties Of Edible Flowers From Thailand. Food Res. Int. 46 563-571

Koirewoa, Y.Aa., Fatimawali, W.I., dan Wiyono. (2012). Isolasi dan Identifikasi Senyawa Flavonoid Dalam Daun Beluntas (Pluchea indica L.). Manado: FMIPA. UNSRAT. Hal 5.
Martinus. B.A., Mimi aria, Muhammad fajri aulia. 2019. Pengaruh Pemberian Salep Ekstrak Etanol Daun Piladang (Solenostemons Cutellarioides (L). Cedd) Selama 15 Hari Secara Topikal Terhadap Aktivitas Penyembuhan Luka Eksisi Pada Tikus Putih Jantan. Jurnal Scienta. 9 (2)-Augustus 2019. 192.203

Mayasari U, Laoli MT. 2018. Karakterisasi simplisia dan skrining fitokimia daun jeruk lemon (citrus limon (L.) Burm.f.). klorofil. Vol (2) 1. 7-13
Perales JW dan Leysa M. 2012. Skrining Fitokimia Dan Aktivitas Antibakteri Bougenvillea Ektrak Tanaman Gablra Sebagai Sumber Potensial Antibakteri Dan Agen Pengubah Warna. Universitas Negri Sutan Kudarat. Fliphina. 121-125

Prihandiwati E, Khumaira AS. 2019. Formulasi dan uji fisik sediaansalep ekstrak daun papaya (carica papaya L) dengan basis hidrokarbon. ISFI Banjarmasinn. 8-21

Priyandari Y, Maulidah SAT. Getah Pohon Jarak (Jatropha Curcas) Topical Mempercepat Lama Penyembuhan Luka Eksisi Mencit (Effect Of Jarak Tree Topical Increase Wound Healing Excision Period Of Mice). Journals Ners Community. 2015;6(2).
Reza MS, Nurdiana Dewi, Ika Kustiyah Oktaviyanti. 2015.Ekstrak Ikan Haruan
(Channa striata) Meningkatkan Jumlah Neokapiler Pada Penyembuhan Luka (Extract Of Haruan ) Inscreases Neocapillaries Count in Wound Healing Process. Universitas Lambung Mangkurat. Banjarmasin. 4(5) dentofasial
Rismana, E., Rosidah I., Prasetyawan Y., Bunga O., dan Erna Y. (2013). Efektivitas Khasiat Pengobatan Luka eksisi Sediaan Gel Mengandung Fraksi Ekstrak Pegagang Berdasarkan Analisis Hidroksiprolin Dan Histopatologi Pada Kulit Kelinci. Vol 41. No 01. Jakarta: Pusat Teknologi Farmasi dan Medika. Badan Pengkajian dan Penerapan Teknologi. Hal 46.
Saleem, H., Atif Usman, fawzi M.,M, Nafees A,. 2020. Bougainvillea glabra (choisy): A Comprehensive Riview On Botany, Traditional Uses, Phytochemistry, Pharmacology And Toxicity. Acta Pol. Pharm. 266, 1–20
Saleem, H., Zengin, G., Ahmad, I., Lee, J.T.B., Htar, T.T., Mahomoodally, F.M., Naidu, R., Ahemad, N., 2019. Multidirectional insights into the biochemical and toxicological. Journal of Ethnopharmacology 266 (2021) 113356 20 properties of Bougainvillea glabra (Choisy.) aerial parts: a functional approach for bioactive compounds. J. Pharmaceut. Biomed. Anal. 170, 132–138
Sasongko H, Anggoro BS, Nurhidayati RW. 2019. The Effect Of Hydrocarbon Ointment Containing Eel Fish (Anguilla Bicolor Bicolor) And Snakehead Fish (Channa Striata) Oil For Wound Healing In Wistar Rats. AIP Conference Proceedings
Sutrisna EM. 2016. Herbal Medicine. Muhammadiyah University Press. 15-18
Wulan, R. 2017. Formulasi dan Uji Stabilitas Fisik Sediaan Salep Antifungi
Ekstrak Daun Ketepeng Cina (Cassia alata L.). UIN Alauddin Makasar.
Published
2022-04-28