FORMULASI DAN EVALUAI STABILITAS FISIK PATCH TRANSDERMAL ALKALOID NIKOTIN DAUN TEMBAKAU (Nicotiana tobacum Linn) DENGAN VARIASI POLIMER DAN ASAM OLEAT

  • Adi Nurmesa Universitas Garut
  • Nurhabibah Nurhabibah Universitas Garut
  • Aji Najihudin Universitas Garut
Keywords: patch transdermal, nikotin, daun tembakau, ethyl cellulose

Abstract

Research on the tobacco leaves  nicotine alkaloid (Nicotiana tobacum L) transdermal patch formulation has been carried out as a cigarette dependence therapy with variations in polymers and oleic acid as a penetration enhancer. The purpose of this study is to formulate a stable transdermal patch of nicotine alkaloid tobacco leaf and to see the effect of adding cellulose, PVP and oleic acid to the release of nicotine in vitro. Transdermal patch formulation consists of nicotine alkaloid tobacco leaf, PVP, ethyl cellulose, PVP, PEG 400, propylenglycol and oleic acid. In this study, 3 formulas were made with concentration variants of PVP: EC namely F1 = 1: 1, F2 = 1: 2, and F3 = 1: 3, where the variations in penetration enhancements in the form of oleic acid were F1: 0.10, F2: 0.15, and F3: 0.20. Evaluation of transdermal patch preparations includes organoleptic, matrix weight test, matrix thickness test, drying shrinkage percentage, moisture uptake, matrix fold resistance test, skin irritation test, patch matrix surface pH test, elongation percentage, frezee and thaw test, nicotine content test, and nicotine release (diffusion cell) test, based on physical stability test of all relatively stable transdermal patch formulas and kinetics of transdermal patch release kinetics following first order and the results of statistical analysis using Variant Analysis (ANOVA) showed differences in F1, F2 and F3, and based on the Korsmayer Peppas test following the non-fick law

References

Kusumma, A.R.P. 2012, Pengaruh Merokok Terhadap Kesehatan Gigi dan Rongga Mulut. Kedokteran Gigi, Universitas Islam Sultan Agung. Diakses tanggal 22 April 2017 http://unisulla.ac.id/newver/images/jurnal/andina%20
Horwood, L.J., Boden J.M., dan David, 2010, Cigaratte Smoking and Depression Test of Cause Linkages Using a Longitudinal Birth Cohort. The Britsh Journal of Psychiatry Diakses di http://bjp.rcpsych.org/content/196/6/440full.pdf+html Diakses tanggal 22 April 2017
Sari, W. Fitriani, Eriani, K. 2010. The Effect of Cigarettes Smoke Exposured Cause Fertility. Jurusan Biologi MIPA Unsyiah Banda Aceh. http://isjd.pdii.lipi.go.id/admisi/jurnal/5okt0808.pdf Diakses tanggal 22 April 2017
Nururahmah. 2014. Pengaruh Rokok Terhadap Kesehatan dan Pembentukan Karakter Manusia, (Prosing Seminar Ilmiah) Universitas Cokroaminoto, Palopo.
Sadikin, D.Z. dan Louisa, Melva., 2008, Program Berhenti Merokok, Departemen Farmakologi dan Terapeutik Fakultas Kedokteran Universitas Indonesia, Jakarta
Rachmawati, Dhitya Sagita. 2015, Optimasi Polietilen Glikol Dan Polivinil Pirolidon Terhadap Laju Pelepasan Dan Uji Moesture Content Patch Ibuprofen, Universitas Jember, Jember.
Bambang, C. 1998. Tembakau Budidaya dan Analisis Usaha Tani, Penerbit Kanisius, Yogyakarta
Agoes, G., 2008, Sistem Penghantaran Obat Pelepasan Terkendali, Penerbit ITB, Bandung
Rowe, R.C, Sheskey, P.J., et.al. 2009, Handbook of Pharmaceutical Excipients. American Pharmaceutical Asociation. Inc.
Harborne, J.B. 2006, Metode Fitokimua Penuntun, Cara Modren Menganalisis Tumbuhan. Penerbit ITB, Bandung
Ameliana, L, 2013, Pengembangan Sediaan Transdermal Patch Meloxicam Tipe Matriks Dalam Beberapa Kombinasi Polimer, Universitas Jember, Jember.
Micrun, N, Andi, N., Nuru, A.Y., Nur, A.K. 2016, Formulasi Patch Kosmetik Lendir Bekicot (Achantina fulica) Dengan Polimer Kitosan Dan Berbagai Variasi Amilum, STIF dan AKAFARMA Kebangsaan, Makassar
Sari, Purwita, Dian, 2015, Formulasi Patch Amoxicilin dengan Kombinasi HPMC dan PVP Sebagai pendekatan Penanganan Sariawan, UMY, Yogyakarta.
Kumar, S.D., Sairan, R., Anandadabu, S., Karpagavalii., Maheswara, A., dan Narayanan, N., 2012., Formulation and Evauation Transdermal Patchs of Salbutamol. Res. Jour. Phar. Bio. Chem. Sci. Vol. 3: 1132-1139
Sahoo, Kumar Biraj., dan Amlya Kenta Mishra, 2013, Formulation and Evaluation of Transdermal Patches of Diclofenac. Departement of Pharmaceutics, Collage Of Pharmaceutical Science Marine Drive Road Puri, Odisha, India
Nirav, S., Sheth dan Rajan B Mistry, 2011, Formulation and Evalution of Transdermal Patches and to Study Permeation Enhancerments effect of eugenol. Jour. of Applied Pharm. Scien.
Nurahmanto, Dwi, 2015, Formulasi dan Evaluasi Sediaan Patch Transdermal Prometazin HCL sebagai Pengobatan Morning Sickness, Universitas Jember, Jember
Rahul Shivajiro Solunke dan Praveen, D, Chaudhari, 2017, Formulation and Evaluation of Repaglinide Patches For Transdermal Drug Delevery. Int. Jour. of Pharm. and Bio. Scie.
Published
2019-10-29
How to Cite
Nurmesa, A., Nurhabibah, N., & Najihudin, A. (2019). FORMULASI DAN EVALUAI STABILITAS FISIK PATCH TRANSDERMAL ALKALOID NIKOTIN DAUN TEMBAKAU (Nicotiana tobacum Linn) DENGAN VARIASI POLIMER DAN ASAM OLEAT. Jurnal Penelitian Farmasi & Herbal, 2(1), 1-8. https://doi.org/10.36656/jpfh.v2i1.124